| A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation | Cell | 2015 | 1.4K |
| A human interactome in three quantitative dimensions organized by stoichiometries and abundances | Cell | 2015 | 788 |
| Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy | Cell Metabolism | 2015 | 345 |
| Widespread Proteome Remodeling and Aggregation in Aging C. elegans | Cell | 2015 | 333 |
| High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics | Nature Biotechnology | 2015 | 297 |
| Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1 | Structure | 2015 | 267 |
| η-Secretase processing of APP inhibits neuronal activity in the hippocampus | Nature | 2015 | 257 |
| Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation | Trends in Endocrinology and Metabolism | 2015 | 249 |
| Extracellular rigidity sensing by talin isoform-specific mechanical linkages | Nature Cell Biology | 2015 | 209 |
| Architecture of the RNA polymerase II-Mediator core initiation complex | Nature | 2015 | 205 |
| Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 193 |
| Acetylation site specificities of lysine deacetylase inhibitors in human cells | Nature Biotechnology | 2015 | 186 |
| A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation | Cell Reports | 2015 | 183 |
| Native architecture of the Chlamydomonas chloroplast revealed by in situ cryo-electron tomography | ELife | 2015 | 166 |
| Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways, and transcription factors | Molecular and Cellular Proteomics | 2015 | 162 |
| Parallel Accumulation-Serial Fragmentation (PASEF): Multiplying Sequencing Speed and Sensitivity by Synchronized Scans in a Trapped Ion Mobility Device | Journal of Proteome Research | 2015 | 161 |
| Accurate protein complex retrieval by affinity enrichment mass spectrometry (AE-MS) rather than affinity purification mass spectrometry (AP-MS) | Molecular and Cellular Proteomics | 2015 | 159 |
| DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination | Cell Research | 2015 | 152 |
| Visualization of LC-MS/MS proteomics data in MaxQuant | Proteomics | 2015 | 143 |
| Functional classification of memory CD8(+) T cells by CX3CR1 expression | Nature Communications | 2015 | 142 |
| Routing of individual polymers in designed patterns | Nature Nanotechnology | 2015 | 142 |
| Fast and sensitive total protein and Peptide assays for proteomic analysis | Analytical Chemistry | 2015 | 139 |
| Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair | Molecular Systems Biology | 2015 | 139 |
| Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation | Genes and Development | 2015 | 136 |
| Structural Basis of Vesicle Formation at the Inner Nuclear Membrane | Cell | 2015 | 136 |
