Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex | Cell | 2012 | 619 |
Decoding human cytomegalovirus | Science | 2012 | 430 |
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 380 |
Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair | Cell | 2012 | 331 |
Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry | Science | 2012 | 323 |
System-wide perturbation analysis with nearly complete coverage of the yeast proteome by single-shot ultra HPLC runs on a bench top Orbitrap | Molecular and Cellular Proteomics | 2012 | 313 |
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis | Nature | 2012 | 269 |
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells | Molecular Systems Biology | 2012 | 266 |
Focused ion beam micromachining of eukaryotic cells for cryoelectron tomography | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 260 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions | Journal of Medicinal Chemistry | 2012 | 245 |
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response | Molecular Cell | 2012 | 239 |
DnaK functions as a central hub in the E. coli chaperone network | Cell Reports | 2012 | 233 |
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis | Nature Cell Biology | 2012 | 231 |
Consecutive proteolytic digestion in an enzyme reactor increases depth of proteomic and phosphoproteomic analysis | Analytical Chemistry | 2012 | 229 |
Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs | Nucleic Acids Research | 2012 | 221 |
False discovery rate estimation for cross-linked peptides identified by mass spectrometry | Nature Methods | 2012 | 219 |
The molecular architecture of the eukaryotic chaperonin TRiC/CCT | Structure | 2012 | 216 |
Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery | Molecular Cell | 2012 | 199 |
Viral immune modulators perturb the human molecular network by common and unique strategies | Nature | 2012 | 193 |
Structure of the stapled p53 peptide bound to Mdm2 | Journal of the American Chemical Society | 2012 | 192 |
Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma | Molecular Systems Biology | 2012 | 174 |
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation | Blood | 2012 | 172 |
Patchwork organization of the yeast plasma membrane into numerous coexisting domains | Nature Cell Biology | 2012 | 172 |
MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation | Cell Stem Cell | 2012 | 163 |
Dynein achieves processive motion using both stochastic and coordinated stepping | Nature Structural and Molecular Biology | 2012 | 159 |