| Why don't physicians follow clinical practice guidelines? A framework for improvement | JAMA - Journal of the American Medical Association | 1999 | 4.4K |
| Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging | Annals of Neurology | 1999 | 2.9K |
| The Banff 97 working classification of renal allograft pathology | Kidney International | 1999 | 2.5K |
| Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer | Nature Genetics | 1999 | 1.6K |
| Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases | Cancer Research | 1999 | 1.6K |
| Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1 | Annual Review of Cell and Developmental Biology | 1999 | 1.6K |
| c-Myc target genes involved in cell growth, apoptosis, and metabolism | Molecular and Cellular Biology | 1999 | 1.3K |
| Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins | Neuron | 1999 | 884 |
| Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia | Cancer Research | 1999 | 859 |
| 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage | Nature | 1999 | 804 |
| Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 694 |
| Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons | Science | 1999 | 686 |
| Cellular and molecular biology of the aquaporin water channels | Annual Review of Biochemistry | 1999 | 684 |
| Analysis of human transcriptomes | Nature Genetics | 1999 | 639 |
| Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 608 |
| Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha | Journal of Clinical Investigation | 1999 | 517 |
| The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 500 |
| Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo | Nature Neuroscience | 1999 | 482 |
| Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 463 |
| Haem oxygenase-1 prevents cell death by regulating cellular iron | Nature Cell Biology | 1999 | 448 |
| Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape | Journal of Cell Biology | 1999 | 433 |
| Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2 | Cancer Research | 1999 | 421 |
| Identification and classification of p53-regulated genes | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 386 |
| Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells | Cancer Research | 1999 | 386 |
| Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies | Circulation Research | 1999 | 382 |
