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Top Articles

#TitleJournalYearCitations
1The 2016 revision of the World Health Organization classification of lymphoid neoplasmsBlood20165,442
2CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell LymphomaNew England Journal of Medicine20024,068
3A clinical approach to diagnosis of autoimmune encephalitisLancet Neurology, The20163,133
4The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid NeoplasmsLeukemia20222,970
5Prone Positioning in Severe Acute Respiratory Distress SyndromeNew England Journal of Medicine20132,618
6DNA methylation-based classification of central nervous system tumoursNature20182,233
7EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative IntentEuropean Urology20172,204
8EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative IntentEuropean Urology20212,199
9Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapyNature Reviews Immunology20131,966
10Strategies and challenges for the next generation of antibody–drug conjugatesNature Reviews Drug Discovery20171,838
11Autoantibodies against type I IFNs in patients with life-threatening COVID-19Science20201,822
12Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysisLancet, The20221,489
13Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)Clinical Neurophysiology20141,469
14Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)Clinical Neurophysiology20171,339
15Hepatitis B virus infectionLancet, The20141,169
16Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trialLancet, The20041,152
17Multiple sclerosisNature Reviews Disease Primers20181,144
18Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'AdulteBlood20101,138
19EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate CancerEuropean Urology20171,100
20Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trialLancet Oncology, The20151,087
21Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registryAnnals of Oncology20191,072
22Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V StudyCardioVascular and Interventional Radiology20091,060
23Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approachLancet Infectious Diseases, The20131,051
24Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group ReportAmerican Journal of Respiratory and Critical Care Medicine20161,046
25Modern diagnosis of GERD: the Lyon ConsensusGut20181,013
26Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for GlioblastomaJAMA - Journal of the American Medical Association2015950
27Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trialLancet, The2012938
28Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting BiasPLoS ONE2008937
29Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trialLancet, The2012914
30Discovery and validation of cell cycle arrest biomarkers in human acute kidney injuryCritical Care2013906
31The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and womenOsteoporosis International2007894
32Niemann-Pick disease type COrphanet Journal of Rare Diseases2010875
33New driver mutations in non-small-cell lung cancerLancet Oncology, The2011870
34Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400Clinical Neurophysiology2009863
35Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): a prospective, multicentre, paired diagnostic studyLancet Oncology, The2019855
36Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective studyLancet Neurology, The2013815
37EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II—2020 Update: Treatment of Relapsing and Metastatic Prostate CancerEuropean Urology2021811
38Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind studyLancet Oncology, The2019808
39Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0©Neurogastroenterology and Motility2021787
40Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 PandemicCirculation2020785
41Evolving Therapies for Myocardial Ischemia/Reperfusion InjuryJournal of the American College of Cardiology2015778
42Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)Lancet, The2016760
43Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis SocietyEuropean Heart Journal2021753
44Advances in the understanding and treatment of sepsis-induced immunosuppressionNature Reviews Nephrology2017751
45Assessment of Myocardial Fibrosis With Cardiovascular Magnetic ResonanceJournal of the American College of Cardiology2011749
46Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 studyLancet, The2012746
47Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trialLancet, The2011718
48Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and managementEuropean Respiratory Journal2016712
49Epilepsy: new advancesLancet, The2015695
50CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent mannerJournal of Experimental Medicine2005684