| 1 | Classification and natural history of clinically identifiable subtypes of cerebral infarction | Lancet, The | 1991 | 2,308 |
| 2 | Revised International Prognostic Scoring System for Myelodysplastic Syndromes | Blood | 2012 | 2,275 |
| 3 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial | Lancet, The | 2005 | 2,235 |
| 4 | EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2021 | 2,224 |
| 5 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 2,127 |
| 6 | Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study | Lancet, The | 2016 | 1,645 |
| 7 | A Phase 3 Trial of Bevacizumab in Ovarian Cancer | New England Journal of Medicine | 2011 | 1,618 |
| 8 | EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood | Nature Reviews Clinical Oncology | 2020 | 1,606 |
| 9 | MicroRNAs in cancer: biomarkers, functions and therapy | Trends in Molecular Medicine | 2014 | 1,496 |
| 10 | Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis | Clinical Gastroenterology and Hepatology | 2012 | 1,435 |
| 11 | Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial | Lancet, The | 2017 | 1,431 |
| 12 | ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications. | Journal of Crohn's and Colitis | 2019 | 1,418 |
| 13 | A Comparison of Multimodal Therapy and Surgery for Esophageal Adenocarcinoma | New England Journal of Medicine | 1996 | 1,375 |
| 14 | World guidelines for falls prevention and management for older adults: a global initiative. | Age and Ageing | 2022 | 1,298 |
| 15 | Risks of cancer in BRCA1-mutation carriers | Lancet, The | 1994 | 1,294 |
| 16 | Management of frailty: opportunities, challenges, and future directions | Lancet, The | 2019 | 1,294 |
| 17 | An SCN9A channelopathy causes congenital inability to experience pain | Nature | 2006 | 1,159 |
| 18 | EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer—2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2024 | 1,143 |
| 19 | Connexin 26 mutations in hereditary non-syndromic sensorineural deafness | Nature | 1997 | 1,121 |
| 20 | Randomized Trial of Laparoscopic-Assisted Resection of Colorectal Carcinoma: 3-Year Results of the UK MRC CLASICC Trial Group | Journal of Clinical Oncology | 2007 | 1,091 |
| 21 | Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial | Lancet, The | 2015 | 1,063 |
| 22 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial | Lancet, The | 2009 | 1,020 |
| 23 | Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS) | European Journal of Cardio-thoracic Surgery | 2019 | 1,012 |
| 24 | International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia | European Respiratory Journal | 2017 | 1,003 |
| 25 | Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. | European Respiratory Journal | 2017 | 976 |
| 26 | Measuring quality of life in routine oncology practice improves communication and patient well-being: a randomized controlled trial. | Journal of Clinical Oncology | 2004 | 966 |
| 27 | Piezo1 integration of vascular architecture with physiological force | Nature | 2014 | 949 |
| 28 | Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50. | Journal of Clinical Oncology | 2021 | 940 |
| 29 | Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity | Nature Reviews Cancer | 2014 | 920 |
| 30 | Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016 | Modern Pathology | 2017 | 871 |
| 31 | Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder | Nature Genetics | 2008 | 870 |
| 32 | New method for detecting slime production by coagulase negative staphylococci. | Journal of Clinical Pathology | 1989 | 818 |
| 33 | EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II—2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer | European Urology | 2021 | 812 |
| 34 | Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity | Nature Genetics | 2012 | 778 |
| 35 | A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis | Journal of Experimental Medicine | 2013 | 774 |
| 36 | British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE | Thorax | 2015 | 744 |
| 37 | Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017 | JAMA - Journal of the American Medical Association | 2020 | 730 |
| 38 | Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial | Lancet, The | 2000 | 729 |
| 39 | Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2016 | 713 |
| 40 | Postoperative pulmonary complications | British Journal of Anaesthesia | 2017 | 713 |
| 41 | A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum | Scientific Reports | 2020 | 708 |
| 42 | Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. | British Journal of Surgery | 2010 | 704 |
| 43 | Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus | Nature Genetics | 2006 | 702 |
| 44 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial | Lancet, The | 2009 | 701 |
| 45 | Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study) | Lancet, The | 2004 | 700 |
| 46 | Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial | Lancet, The | 2011 | 673 |
| 47 | Current concepts of molecular aspects of bone healing | Injury | 2005 | 662 |
| 48 | Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis | The Lancet Gastroenterology and Hepatology | 2020 | 653 |
| 49 | Targeting Toll-like receptors: emerging therapeutics? | Nature Reviews Drug Discovery | 2010 | 640 |
| 50 | Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome | Gastroenterology | 2017 | 633 |