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Top Articles

#TitleJournalYearCitations
1Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive studyLancet, The202012,047
2Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, ChinaJAMA Internal Medicine20205,068
3Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseasesCell Research20083,428
4Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy20212,079
5NF-κB in biology and targeted therapy: new insights and translational implicationsSignal Transduction and Targeted Therapy20241,591
6Prevalence of chronic kidney disease in China: a cross-sectional surveyLancet, The20121,511
7Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infectionFrontiers of Medicine20201,423
8Effectiveness of convalescent plasma therapy in severe COVID-19 patientsProceedings of the National Academy of Sciences of the United States of America20201,212
9Gut microbiome and serum metabolome alterations in obesity and after weight-loss interventionNature Medicine20171,182
10Microglia in neurodegenerative diseases: mechanism and potential therapeutic targetsSignal Transduction and Targeted Therapy20231,114
11Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin InflammationImmunity2011802
12CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancerNucleic Acids Research2010752
13Prognostic accuracy of day versus night ambulatory blood pressure: a cohort studyLancet, The2007685
14Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancerNature Communications2022685
15A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertensionLancet, The2016667
16Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trialBMJ, The0621
17Viral and host factors related to the clinical outcome of COVID-19Nature2020611
18The biphasic function of microglia in ischemic strokeProgress in Neurobiology2017588
19Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, ChinaJournal of Infection2020567
20Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer MetastasisCancer Research2018563
21Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in ChinaJAMA - Journal of the American Medical Association2015554
22The Lancet Commission on diabetes: using data to transform diabetes care and patient livesLancet, The2020551
23Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosisProceedings of the National Academy of Sciences of the United States of America2006550
24Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor MicroenvironmentFrontiers in Immunology2020533
25COVID-19 with Different Severities: A Multicenter Study of Clinical FeaturesAmerican Journal of Respiratory and Critical Care Medicine2020530
26Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patientsChinese Medical Journal2020525
27Effect of Laparoscopic vs Open Distal Gastrectomy on 3-Year Disease-Free Survival in Patients With Locally Advanced Gastric CancerJAMA - Journal of the American Medical Association2019523
28Stromal cells in tumor microenvironment and breast cancerCancer and Metastasis Reviews2012510
29The endosomal-lysosomal system: from acidification and cargo sorting to neurodegenerationTranslational Neurodegeneration2015504
30Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in MiceStem Cells2014500
31Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarctionJournal of Molecular and Cellular Cardiology2013488
32Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcomaNature Communications2020484
33Genome-wide association study identifies susceptibility loci for IgA nephropathyNature Genetics2011474
34Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogensNature Genetics2014464
35The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021Cancer Communications2021464
36Incidence and Etiology of Drug-Induced Liver Injury in Mainland ChinaGastroenterology2019454
37Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19Science Translational Medicine2020434
38Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and humanProceedings of the National Academy of Sciences of the United States of America2005430
39Neutrophils in cancer carcinogenesis and metastasisJournal of Hematology and Oncology2021430
40Vascularized 3D printed scaffolds for promoting bone regenerationBiomaterials2019427
41Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancerNature Medicine2020427
42M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124Theranostics2019413
43Isorhamnetin: A review of pharmacological effectsBiomedicine and Pharmacotherapy2020413
44Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid BerberineJournal of Clinical Endocrinology and Metabolism2008412
45Comparative Proteomic Analysis Provides New Insights into Chilling Stress Responses in RiceMolecular and Cellular Proteomics2006403
46Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategiesJournal of Hematology and Oncology2022403
47METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XISTMolecular Cancer2020398
48Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiotaAlzheimer's and Dementia2019390
49Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironmentBiomaterials2021387
50ICEberg 2.0: an updated database of bacterial integrative and conjugative elementsNucleic Acids Research2019376