| 1 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,271 |
| 2 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 5,761 |
| 3 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 5,597 |
| 4 | Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus | Arthritis and Rheumatism | 2012 | 3,803 |
| 5 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 3,438 |
| 6 | Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization | JAMA - Journal of the American Medical Association | 2021 | 3,122 |
| 7 | Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2017 | 2,927 |
| 8 | Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010 | Lancet, The | 2014 | 2,673 |
| 9 | Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study | Lancet, The | 2010 | 2,274 |
| 10 | SignalP 6.0 predicts all five types of signal peptides using protein language models | Nature Biotechnology | 2022 | 2,271 |
| 11 | Toward discovery science of human brain function | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 2,236 |
| 12 | Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee | Clinical Neurophysiology | 2015 | 2,172 |
| 13 | Bioelectrical impedance analysis?part I: review of principles and methods | Clinical Nutrition | 2004 | 2,138 |
| 14 | Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers | JAMA - Journal of the American Medical Association | 2017 | 2,116 |
| 15 | Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis | Nature Genetics | 2006 | 2,091 |
| 16 | Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society | European Heart Journal | 2013 | 2,082 |
| 17 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 2,004 |
| 18 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 1,956 |
| 19 | When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts | BMC Medical Research Methodology | 2017 | 1,901 |
| 20 | Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study | BMJ: British Medical Journal | 2008 | 1,833 |
| 21 | A Simple Estimate of Glomerular Filtration Rate in Children Derived From Body Length and Plasma Creatinine | Pediatrics | 1976 | 1,778 |
| 22 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 1,761 |
| 23 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study | Lancet, The | 1998 | 1,747 |
| 24 | Tertiary lymphoid structures improve immunotherapy and survival in melanoma | Nature | 2020 | 1,734 |
| 25 | Bioelectrical impedance analysis—part II: utilization in clinical practice | Clinical Nutrition | 2004 | 1,649 |
| 26 | Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study | Lancet, The | 2012 | 1,646 |
| 27 | Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands | Journal of Cerebral Blood Flow and Metabolism | 2007 | 1,605 |
| 28 | Identification of common genetic risk variants for autism spectrum disorder | Nature Genetics | 2019 | 1,602 |
| 29 | Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects: Opinion | Human Reproduction | 2001 | 1,588 |
| 30 | TOWARD A FUNCTIONAL ANALYSIS OF SELF-INJURY | Journal of Applied Behavior Analysis | 1994 | 1,574 |
| 31 | ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma | International Journal of Gynecological Cancer | 2021 | 1,524 |
| 32 | International Consensus on Use of Continuous Glucose Monitoring | Diabetes Care | 2017 | 1,488 |
| 33 | 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension | European Respiratory Journal | 2023 | 1,475 |
| 34 | European Position Paper on Rhinosinusitis and Nasal Polyps 2020 | Rhinology | 2020 | 1,474 |
| 35 | Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) | Clinical Neurophysiology | 2014 | 1,469 |
| 36 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,436 |
| 37 | Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis | Journal of Clinical Epidemiology | 2008 | 1,397 |
| 38 | Lipoprotein(a) as a cardiovascular risk factor: current status | European Heart Journal | 2010 | 1,394 |
| 39 | Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention | JAMA - Journal of the American Medical Association | 2007 | 1,394 |
| 40 | Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder | Nature Genetics | 2018 | 1,378 |
| 41 | Large-scale association analyses identify host factors influencing human gut microbiome composition | Nature Genetics | 2021 | 1,357 |
| 42 | Evaluating storage, retention, and retrieval in disordered memory and learning | Neurology | 1974 | 1,282 |
| 43 | Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) | Intensive Care Medicine | 2020 | 1,236 |
| 44 | Common variants conferring risk of schizophrenia | Nature | 2009 | 1,219 |
| 45 | Credit Booms Gone Bust: Monetary Policy, Leverage Cycles, and Financial Crises, 1870–2008 | American Economic Review | 2012 | 1,217 |
| 46 | Association of Gestational Weight Gain With Maternal and Infant Outcomes | JAMA - Journal of the American Medical Association | 2017 | 1,216 |
| 47 | Autism spectrum disorder | Nature Reviews Disease Primers | 2020 | 1,216 |
| 48 | Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia | JAMA - Journal of the American Medical Association | 2015 | 1,214 |
| 49 | Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2020 | 1,182 |
| 50 | 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 1,179 |