| 1 | New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) | European Journal of Cancer | 2009 | 22,433 |
| 2 | The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis | Arthritis and Rheumatism | 1988 | 16,059 |
| 3 | 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2016 | 10,440 |
| 4 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells | Nature Cell Biology | 2007 | 9,812 |
| 5 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,271 |
| 6 | Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology | Journal of the American Society of Echocardiography | 2005 | 8,873 |
| 7 | Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 | Journal of the American College of Cardiology | 2020 | 8,723 |
| 8 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 8,707 |
| 9 | The 2007 WHO Classification of Tumours of the Central Nervous System | Acta Neuropathologica | 2007 | 8,017 |
| 10 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 7,766 |
| 11 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease | Alzheimer's and Dementia | 2018 | 7,586 |
| 12 | Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline | Journal of Clinical Endocrinology and Metabolism | 2011 | 7,409 |
| 13 | Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria | Annals of Neurology | 2011 | 7,128 |
| 14 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction | Gene | 1989 | 6,917 |
| 15 | Mild Cognitive Impairment | Archives of Neurology | 1999 | 6,366 |
| 16 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 6,341 |
| 17 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 5,761 |
| 18 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 5,597 |
| 19 | Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography | Journal of the American Society of Echocardiography | 2010 | 5,552 |
| 20 | Mild cognitive impairment as a diagnostic entity | Journal of Internal Medicine | 2004 | 5,531 |
| 21 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 | Cancer Cell | 2010 | 5,432 |
| 22 | Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Nature | 1993 | 5,310 |
| 23 | 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults | JAMA - Journal of the American Medical Association | 2014 | 5,272 |
| 24 | Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial | Lancet, The | 2016 | 4,985 |
| 25 | CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials | BMJ: British Medical Journal | 2010 | 4,977 |
| 26 | Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus | Gut | 2013 | 4,879 |
| 27 | Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2009 | 4,776 |
| 28 | scikit-image: image processing in Python | PeerJ | 0 | 4,385 |
| 29 | Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2016 | 4,296 |
| 30 | Definition and classification of cancer cachexia: an international consensus | Lancet Oncology, The | 2011 | 4,286 |
| 31 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,117 |
| 32 | Development of an upper extremity outcome measure: The DASH (disabilities of the arm, shoulder, and head) | American Journal of Industrial Medicine | 1996 | 4,002 |
| 33 | Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria” | Annals of Neurology | 2005 | 3,819 |
| 34 | Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS | Neuron | 2011 | 3,749 |
| 35 | Colorectal cancer | Lancet, The | 2019 | 3,727 |
| 36 | The Somatic Genomic Landscape of Glioblastoma | Cell | 2013 | 3,719 |
| 37 | Clinical Rating Systems for the Ankle-Hindfoot, Midfoot, Hallux, and Lesser Toes | Foot and Ankle International | 1994 | 3,699 |
| 38 | Nonalcoholic Fatty Liver Disease | New England Journal of Medicine | 2002 | 3,689 |
| 39 | Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion | Nature Medicine | 2002 | 3,664 |
| 40 | International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma | Lancet Oncology, The | 2014 | 3,607 |
| 41 | Burden of valvular heart diseases: a population-based study | Lancet, The | 2006 | 3,555 |
| 42 | Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment | Journal of Internal Medicine | 2004 | 3,478 |
| 43 | Receiver Operating Characteristic Curve in Diagnostic Test Assessment | Journal of Thoracic Oncology | 2010 | 3,448 |
| 44 | Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II | Arthritis and Rheumatism | 2008 | 3,418 |
| 45 | The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After | Surgery | 2017 | 3,383 |
| 46 | Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade | Lancet Neurology, The | 2010 | 3,373 |
| 47 | Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases | Hepatology | 2018 | 3,329 |
| 48 | Post-acute COVID-19 syndrome | Nature Medicine | 2021 | 3,262 |
| 49 | Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles | Neuron | 2003 | 3,227 |
| 50 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,197 |
