Abstract
Objective:
Arabinoxylan (AX) consumption is associated with metabolic improvement during diabetes and with modulation of ghrelin, an orexigenic gut hormone. The effect of AX consumption on ghrelin secretion in disturbed metabolic states is unknown. Therefore, we investigated the postprandial responses to AX consumption of serum glucose, insulin and triglycerides and plasma total and acylated ghrelin in subjects with impaired glucose tolerance (IGT).
Design:
Randomized, single-blind, controlled, crossover intervention trial.
Subjects:
Seven female and four male adults with IGT, aged 55.5 years, and body mass index (BMI) 30.1 kg/m2.
Intervention:
Subjects received either placebo or 15 g AX supplement for 6 weeks with a 6-week washout period in-between.
Main outcome measurements:
Postprandial responses of serum glucose, insulin and triglycerides, and plasma total and acylated ghrelin after a liquid meal challenge test (LMCT) measured at the beginning and at the end of the dietary intervention at −20, −5, 0, 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 min.
Results:
After LMCT, AX consumption resulted in lower postprandial responses in serum glucose, insulin and triglycerides (P<0.05). Compared to placebo, total plasma ghrelin was also reduced by 42±8 pg/ml (P<0.001) after AX consumption with no difference in plasma acylated ghrelin.
Conclusion:
AX consumption improved postprandial metabolic responses after an LMCT in subjects with IGT and reduced total ghrelin response. However, acylated ghrelin responses were unchanged, suggesting that the acylated ghrelin-mediated orexigenic regulation is not improved as only total plasma ghrelin decreased.
Sponsorship:
Federal Ministry of Education and Research Germany (PTJ-BIO/0313042C).
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Guarantor: C Koebnick.
Contributors: ALG, BO and CK were responsible for data analysis and writing of the manuscript. H-JFZ, FM and AHFP were responsible for the study design. SCR, AM and JS were involved in the collection and the analysis of the data. MOW, MM and NNR had an advisory function and contributed to the writing of the manuscript. BO, JD, NK and MS were responsible for laboratory analysis. All authors contributed to the manuscript. The authors do not have any financial or personal conflicts of interest.
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Garcia, A., Otto, B., Reich, SC. et al. Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance. Eur J Clin Nutr 61, 334–341 (2007). https://doi.org/10.1038/sj.ejcn.1602525
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DOI: https://doi.org/10.1038/sj.ejcn.1602525
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