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Sildenafil (Viagra®) • Tolerability, contraindications and drug interactions

Verträglichkeit, Kontraindikationen, Arzneimittelinteraktionen

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Summary

Placebo-controlled studies have clearly demonstrated the efficacy of sildenafil in the treatment of erectile dysfunction. It's tolerability cannot yet be judged definitively based on the available information. Some findings indicate that in addition to established contraindications (allergy against the active ingredient, concomitant nitrate and NO-donor treatment, retinitis pigmentosa) factors such as coronary heart disease, advanced age, impaired liver function and drug interactions require special attention by the prescribing physician to secure drug safety.

Zusammenfassung

Plazebokontrollierte Studien haben die Wirksamkeit von Sildenafil zur Behandlung der erektilen Dysfunktion klar belegt. Seine Verträglichkeit läßt sich nach den bisher vorliegenden Informationen noch nicht abschließend beurteilen. Einige Befunde deuten darauf hin, daß neben den bestehenden Kontraindikationen (Allergie, gleichzeitige Nitratbehandlung, Retinitis pigmentosa) Faktoren wie koronare Herzkrankheit, hohes Alter, gestörte Leberfunktion und Interaktion mit anderen Arzneimitteln für eine sichere Therapie die besondere Aufmerksamkeit des verordnenden Arztes erfordern.

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Sperling, H., Michel, M. & Rübben, H. Sildenafil (Viagra®) • Tolerability, contraindications and drug interactions. Urologe 38, 124–127 (1999). https://doi.org/10.1007/s001200050254

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  • DOI: https://doi.org/10.1007/s001200050254

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