Most Cited Articles of Biochemistry

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry1976199.3K
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extractionAnalytical Biochemistry198756.3K
QIIME allows analysis of high-throughput community sequencing dataNature Methods201022.4K
The hallmarks of cancerCell200020.3K
Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionAnalytical Biochemistry197918.6K
Features and development of CootActa Crystallographica Section D: Biological Crystallography201016.1K
PHENIX: a comprehensive Python-based system for macromolecular structure solutionActa Crystallographica Section D: Biological Crystallography201015.8K
Crystallography & NMR system: A new software suite for macromolecular structure determinationActa Crystallographica Section D: Biological Crystallography199814K
Cluster analysis and display of genome-wide expression patternsProceedings of the National Academy of Sciences of the United States of America199812.5K
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresJournal of Applied Crystallography199111.7K
BEDTools: a flexible suite of utilities for comparing genomic featuresBioinformatics201011.5K
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology197711.2K
Molecular portraits of human breast tumoursNature200010.9K
Significance analysis of microarrays applied to the ionizing radiation responseProceedings of the National Academy of Sciences of the United States of America20019.7K
Improved tools for biological sequence comparisonProceedings of the National Academy of Sciences of the United States of America19889.5K
jModelTest 2: more models, new heuristics and parallel computingNature Methods20129.5K
MolProbity: all-atom structure validation for macromolecular crystallographyActa Crystallographica Section D: Biological Crystallography20109.4K
Studies on transformation of Escherichia coli with plasmidsJournal of Molecular Biology19839.4K
Multiplex genome engineering using CRISPR/Cas systemsScience20139.3K
UCHIME improves sensitivity and speed of chimera detectionBioinformatics20119.2K
A method and server for predicting damaging missense mutationsNature Methods20109.1K
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantificationNature Biotechnology20088.8K
Overview of the CCP4 suite and current developmentsActa Crystallographica Section D: Biological Crystallography20118.7K
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomesJournal of Molecular Biology20018.7K
The chemistry of graphene oxideChemical Society Reviews20108.5K