| 1 | The role of the FKBP51–Hsp90 complex in Alzheimer’s disease: An emerging new drug target | 2.5 | 21 | Citations (PDF) |
| 2 | Malachite Green Assay for the Discovery of Heat-Shock Protein 90 Inhibitors | 0.2 | 5 | Citations (PDF) |
| 3 | The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer’s Disease | 3.1 | 15 | Citations (PDF) |
| 4 | Advances towards Understanding the Mechanism of Action of the Hsp90 Complex | 3.1 | 50 | Citations (PDF) |
| 5 | Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant | 3.1 | 3 | Citations (PDF) |
| 6 | Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone | 4.4 | 38 | Citations (PDF) |
| 7 | Two-colour single-molecule photoinduced electron transfer fluorescence imaging microscopy of chaperone dynamics | 11.0 | 33 | Citations (PDF) |
| 8 | Clinical and functional analyses of AIPL1 variants reveal mechanisms of pathogenicity linked to different forms of retinal degeneration | 2.7 | 20 | Citations (PDF) |
| 9 | The structure-function relationship of oncogenic LMTK3 | 8.2 | 38 | Citations (PDF) |
| 10 | Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client Interactions | 2.4 | 54 | Citations (PDF) |
| 11 | Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90 | 4.4 | 53 | Citations (PDF) |
| 12 | Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1 | 11.0 | 56 | Citations (PDF) |
| 13 | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM | 8.2 | 55 | Citations (PDF) |
| 14 | In vivo bioassay to test the pathogenicity of missense human AIP variants | 2.2 | 24 | Citations (PDF) |
| 15 | RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex | 11.0 | 76 | Citations (PDF) |
| 16 | The integrity and organization of the human AIPL1 functional domains is critical for its role as a HSP90-dependent co-chaperone for rod PDE6 | 2.1 | 6 | Citations (PDF) |
| 17 | The Stoichiometric Interaction of the Hsp90-Sgt1-Rar1 Complex by CD and SRCD Spectroscopy | 2.4 | 15 | Citations (PDF) |
| 18 | Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection | 2.4 | 35 | Citations (PDF) |
| 19 | HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients | 4.4 | 30 | Citations (PDF) |
| 20 | Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System | 4.4 | 64 | Citations (PDF) |
| 21 | The integrity and organization of the human AIPL1 functional domains is critical for its role as a HSP90-dependent co-chaperone for rod PDE6 | 2.1 | 22 | Citations (PDF) |
| 22 | Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients | 5.2 | 85 | Citations (PDF) |
| 23 | The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System | 2.5 | 65 | Citations (PDF) |
| 24 | Regulatory Mechanisms of Hsp90 | 0.0 | 30 | Citations (PDF) |
| 25 | The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90 | 1.5 | 39 | Citations (PDF) |
| 26 | Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer’s Disease | 1.7 | 41 | Citations (PDF) |
| 27 | Mechanisms of Hsp90 regulation | 2.3 | 309 | Citations (PDF) |
| 28 | Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With MissenseAIPMutations | 3.3 | 60 | Citations (PDF) |
| 29 | The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding | 11.0 | 76 | Citations (PDF) |
| 30 | Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism | 9.5 | 92 | Citations (PDF) |
| 31 | Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors | 4.4 | 78 | Citations (PDF) |
| 32 | Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes | 3.2 | 17 | Citations (PDF) |
| 33 | c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells | 4.4 | 63 | Citations (PDF) |
| 34 | Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors | 8.7 | 123 | Citations (PDF) |
| 35 | Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90 | 1.8 | 25 | Citations (PDF) |
| 36 | Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1 | 2.5 | 99 | Citations (PDF) |
| 37 | Structural basis for the interaction of HSP90 with R2TP and TTT complexes | 0.0 | 0 | Citations (PDF) |
| 38 | Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90 | 15.9 | 84 | Citations (PDF) |
| 39 | ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system | 9.5 | 153 | Citations (PDF) |
| 40 | Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins | 5.2 | 43 | Citations (PDF) |
| 41 | Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity | 5.3 | 125 | Citations (PDF) |
| 42 | CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle ProgressionCell, 2012, 151, 1308-1318 | 23.8 | 144 | Citations (PDF) |
| 43 | Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine | 8.7 | 132 | Citations (PDF) |
| 44 | Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal α-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition | 1.5 | 74 | Citations (PDF) |
| 45 | The ‘active life’ of Hsp90 complexes | 2.5 | 173 | Citations (PDF) |
| 46 | Co-Crystalization and In Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors | 1.5 | 20 | Citations (PDF) |
| 47 | Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies | 2.5 | 27 | Citations (PDF) |
| 48 | Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity | 8.7 | 165 | Citations (PDF) |
| 49 | Cloning, expression and structure determination of the major extracellular domain of the PepT***1 oligopeptide transporter | 2.5 | 0 | Citations (PDF) |
| 50 | Features of the
Streptomyces hygroscopicus
HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90 | 2.3 | 35 | Citations (PDF) |
| 51 | A Combinatorial Method to Enable Detailed Investigation of Protein–Protein Interactions | 1.8 | 5 | Citations (PDF) |
| 52 | A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90α/β | 3.8 | 20 | Citations (PDF) |
| 53 | Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies | 2.4 | 24 | Citations (PDF) |
| 54 | Detection of the ATPase Activity of the Molecular Chaperones Hsp90 and Hsp72 Using the Transcreener™ ADP Assay Kit | 2.0 | 32 | Citations (PDF) |
| 55 | Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function | 8.7 | 190 | Citations (PDF) |
| 56 | Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors | 8.7 | 124 | Citations (PDF) |
| 57 | Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain | 5.9 | 85 | Citations (PDF) |
| 58 | A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s | 3.3 | 53 | Citations (PDF) |
| 59 | Structural–Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90 | 3.0 | 20 | Citations (PDF) |
| 60 | Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90 | 2.5 | 54 | Citations (PDF) |
| 61 | Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes | 5.2 | 120 | Citations (PDF) |
| 62 | 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer | 4.7 | 421 | Citations (PDF) |
| 63 | Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37 | 8.7 | 200 | Citations (PDF) |
| 64 | Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors | 4.7 | 85 | Citations (PDF) |
| 65 | Molecular Characterization of Macbecin as an Hsp90 Inhibitor | 4.7 | 61 | Citations (PDF) |
| 66 | The Hsp90 molecular chaperone: an open and shut case for treatment | 2.3 | 430 | Citations (PDF) |
| 67 | The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis | 2.0 | 98 | Citations (PDF) |
| 68 | Chaperone ligand-discrimination by the TPR-domain protein Tah1 | 2.3 | 50 | Citations (PDF) |
| 69 | In the Yeast Heat Shock Response, Hsf1-Directed Induction of Hsp90 Facilitates the Activation of the Slt2 (Mpk1) Mitogen-Activated Protein Kinase Required for Cell Integrity | 2.7 | 59 | Citations (PDF) |
| 70 | DNA fragmentation-based combinatorial approaches to soluble protein expression | 5.1 | 20 | Citations (PDF) |
| 71 | DNA fragmentation based combinatorial approaches to soluble protein expression | 5.1 | 11 | Citations (PDF) |
| 72 | Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery | 14.1 | 1,058 | Citations (PDF) |
| 73 | Structure of an Hsp90-Cdc37-Cdk4 Complex | 8.7 | 295 | Citations (PDF) |
| 74 | Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex | 31.3 | 943 | Citations (PDF) |
| 75 | Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol | 4.7 | 65 | Citations (PDF) |
| 76 | Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications | 3.5 | 35 | Citations (PDF) |
| 77 | Expressed in the Yeast
Saccharomyces cerevisiae
, Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase | 2.7 | 68 | Citations (PDF) |
| 78 | The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors | 1.5 | 234 | Citations (PDF) |
| 79 | Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex | 1.9 | 43 | Citations (PDF) |
| 80 | A Two-Hybrid Screen of the Yeast Proteome for Hsp90 Interactors Uncovers a Novel Hsp90 Chaperone Requirement in the Activity of a Stress-Activated Mitogen-Activated Protein Kinase, Slt2p (Mpk1p) | 2.7 | 170 | Citations (PDF) |
| 81 | Chaperoned Ubiquitylation—Crystal Structures of the CHIP U Box E3 Ubiquitin Ligase and a CHIP-Ubc13-Uev1a Complex | 8.7 | 420 | Citations (PDF) |
| 82 | Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach | 2.5 | 42 | Citations (PDF) |
| 83 | Co-chaperone Regulation of Conformational Switching in the Hsp90 ATPase Cycle | 1.3 | 199 | Citations (PDF) |
| 84 | Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery | 5.2 | 176 | Citations (PDF) |
| 85 | High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity | 2.0 | 206 | Citations (PDF) |
| 86 | The Mechanism of Hsp90 Regulation by the Protein Kinase-Specific Cochaperone p50cdc37 | 23.8 | 346 | Citations (PDF) |
| 87 | Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast | 0.2 | 56 | Citations (PDF) |
| 88 | Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90β, a property that can be exploited in screens for new Hsp90 chaperone inhibitors | 1.6 | 52 | Citations (PDF) |
| 89 | Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions | 8.7 | 482 | Citations (PDF) |
| 90 | Regulation of Hsp90 ATPase Activity by the Co-chaperone Cdc37p/p50 | 1.3 | 259 | Citations (PDF) |
| 91 | Activation of the ATPase Activity of Hsp90 by the Stress-Regulated Cochaperone Aha1 | 8.7 | 532 | Citations (PDF) |
| 92 | Title is missing! | 1.6 | 19 | Citations (PDF) |
| 93 | Structure, function, and mechanism of the Hsp90 molecular chaperone | 4.5 | 179 | Citations (PDF) |
| 94 | Structure and in vivo function of Hsp90 | 4.8 | 301 | Citations (PDF) |
| 95 | The ATPase cycle of Hsp90 drives a molecular clamp' via transient dimerization of the N-terminal domains | 5.2 | 460 | Citations (PDF) |
| 96 | Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin | 4.7 | 1,000 | Citations (PDF) |
| 97 | Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones | 5.2 | 399 | Citations (PDF) |
| 98 | ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo | 5.2 | 696 | Citations (PDF) |
| 99 | Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone | 23.8 | 1,253 | Citations (PDF) |
| 100 | A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone | 11.0 | 230 | Citations (PDF) |
| 101 | Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect | 1.6 | 15 | Citations (PDF) |
| 102 | Recursive PCR: a novel technique for total gene synthesis | 2.2 | 228 | Citations (PDF) |
| 103 | The aconitase of Escherichia coli. Nucleotide sequence of the aconitase gene and amino acid sequence similarity with mitochondrial aconitases, the iron-responsive-element-binding protein and isopropylmalate isomerases | 0.2 | 76 | Citations (PDF) |
| 104 | Cloning of theHIS3 gene ofYarrowia lipolytica | 1.2 | 3 | Citations (PDF) |
| 105 | The aconitase of Escherichia coli: purification of the enzyme and molecular cloning and map location of the gene (acn) | 1.5 | 38 | Citations (PDF) |
| 106 | The dihydropyridine LA1011 modulates multiple Hsp90—co-chaperone interactions relevant to Alzheimer’s disease | 2.5 | 0 | Citations (PDF) |
