| 1 | Structure-guided design of partial agonists at an opioid receptor | 11.0 | 19 | Citations (PDF) |
| 2 | Synthesis and Pharmacology of a Morphinan-Derived Dual Mu–Kappa Opioid Receptor Agonist Analgesic | 2.8 | 3 | Citations (PDF) |
| 3 | Novel Tetraolefinic Chain Phenyl Substituted Endocannabinoid Probes | 4.8 | 1 | Citations (PDF) |
| 4 | Development of an automated, high-throughput assay to detect angiotensin AT-receptor agonistic compounds by nitric oxide measurements | 2.0 | 5 | Citations (PDF) |
| 5 | Constitutive activation mechanism of a class C GPCR | 6.0 | 13 | Citations (PDF) |
| 6 | Detection of autism spectrum disorder-related pathogenic trio variants by a novel structure-based approach | 2.7 | 7 | Citations (PDF) |
| 7 | Virtual Screening of a Chemically Diverse “Superscaffold” Library Enables Ligand Discovery for a Key GPCR Target | 2.5 | 27 | Citations (PDF) |
| 8 | Scalable computation of anisotropic vibrations for large macromolecular assemblies | 11.0 | 1 | Citations (PDF) |
| 9 | Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2 | 2.1 | 6 | Citations (PDF) |
| 10 | A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site | 11.0 | 24 | Citations (PDF) |
| 11 | Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models | 11.0 | 22 | Citations (PDF) |
| 12 | Development of Calcium-Dependent Phospholipase A2 Inhibitors to Target Cellular Senescence and Oxidative Stress in Neurodegenerative Diseases | 4.2 | 21 | Citations (PDF) |
| 13 | Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease | 3.9 | 22 | Citations (PDF) |
| 14 | Eosinophils protect pressure overload- and β-adrenoreceptor agonist-induced cardiac hypertrophy. | 5.7 | 25 | Citations (PDF) |
| 15 | Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs | 2.8 | 68 | Citations (PDF) |
| 16 | Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells | 11.0 | 48 | Citations (PDF) |
| 17 | Molecular mechanism of biased signaling at the kappa opioid receptor | 11.0 | 96 | Citations (PDF) |
| 18 | Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists | 5.2 | 50 | Citations (PDF) |
| 19 | Computational approaches streamlining drug discovery | 31.8 | 1,240 | Citations (PDF) |
| 20 | Ligand and G-protein selectivity in the κ-opioid receptor | 31.8 | 83 | Citations (PDF) |
| 21 | Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics | 4.8 | 16 | Citations (PDF) |
| 22 | Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats | 11.0 | 25 | Citations (PDF) |
| 23 | Structural basis of GABA reuptake inhibition | 31.8 | 129 | Citations (PDF) |
| 24 | Inactive and active state structures template selective tools for the human 5-HT5A receptor | 6.0 | 28 | Citations (PDF) |
| 25 | Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma | 5.3 | 28 | Citations (PDF) |
| 26 | Germline selection of PTPN11 (HGNC:9644) variants make a major contribution to both Noonan syndrome's high birth rate and the transmission of sporadic cancer variants resulting in fetal abnormality | 1.0 | 8 | Citations (PDF) |
| 27 | Structure-based design of bitopic ligands for the µ-opioid receptor | 31.8 | 133 | Citations (PDF) |
| 28 | Optical Control of Cannabinoid Receptor 2-Mediated Ca2+ Release Enabled by Synthesis of Photoswitchable Probes | 12.2 | 56 | Citations (PDF) |
| 29 | Structural insights on ligand recognition at the human leukotriene B4 receptor 1 | 11.0 | 21 | Citations (PDF) |
| 30 | Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management | 4.8 | 27 | Citations (PDF) |
| 31 | Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues. | 1.9 | 7 | Citations (PDF) |
| 32 | Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists | 4.8 | 12 | Citations (PDF) |
| 33 | Synthon-based ligand discovery in virtual libraries of over 11 billion compounds | 31.8 | 410 | Citations (PDF) |
| 34 | Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR | 3.1 | 30 | Citations (PDF) |
| 35 | Structural basis of the activation of a metabotropic GABA receptor | 31.8 | 143 | Citations (PDF) |
| 36 | Biased Signaling of the G-Protein-Coupled Receptor β2AR Is Governed by Conformational Exchange Kinetics | 2.5 | 58 | Citations (PDF) |
| 37 | O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity | 12.2 | 45 | Citations (PDF) |
| 38 | Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs | 8.2 | 110 | Citations (PDF) |
| 39 | Harnessing Ion-Binding Sites for GPCR Pharmacology | 10.7 | 126 | Citations (PDF) |
| 40 | Structural basis of ligand recognition at the human MT1 melatonin receptor | 31.8 | 192 | Citations (PDF) |
| 41 | XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity | 31.8 | 138 | Citations (PDF) |
| 42 | Computational design for thermostabilization of GPCRs | 4.8 | 13 | Citations (PDF) |
| 43 | Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists | 8.2 | 132 | Citations (PDF) |
| 44 | Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors | 11.0 | 71 | Citations (PDF) |
| 45 | Exploring Pairwise Chemical Crosslinking To Study Peptide–Receptor Interactions | 1.9 | 7 | Citations (PDF) |
| 46 | Crystal Structure of the Human Cannabinoid Receptor CB2Cell, 2019, 176, 459-467.e13 | 23.8 | 382 | Citations (PDF) |
| 47 | A Thieno[2,3-d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor | 4.8 | 30 | Citations (PDF) |
| 48 | 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR PolypharmacologyCell, 2018, 172, 719-730.e14 | 23.8 | 236 | Citations (PDF) |
| 49 | Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling | 2.5 | 177 | Citations (PDF) |
| 50 | Intracellular Transfer of Na+ in an Active-State G-Protein-Coupled Receptor | 2.5 | 98 | Citations (PDF) |
| 51 | Structure of the Nanobody-Stabilized Active State of the Kappa Opioid ReceptorCell, 2018, 172, 55-67.e15 | 23.8 | 369 | Citations (PDF) |
| 52 | Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers | 2.7 | 15 | Citations (PDF) |
| 53 | People also looked at | 2.4 | 31 | Citations (PDF) |
| 54 | Crystal structure of the Frizzled 4 receptor in a ligand-free state | 31.8 | 105 | Citations (PDF) |
| 55 | Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor | 12.2 | 53 | Citations (PDF) |
| 56 | Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor | 9.6 | 47 | Citations (PDF) |
| 57 | Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor | 4.8 | 53 | Citations (PDF) |
| 58 | Structural basis for selectivity and diversity in angiotensin II receptors | 31.8 | 207 | Citations (PDF) |
| 59 | An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio | 11.0 | 117 | Citations (PDF) |
| 60 | Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody | 5.3 | 63 | Citations (PDF) |
| 61 | Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist | 7.6 | 47 | Citations (PDF) |
| 62 | Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling | 12.2 | 105 | Citations (PDF) |
| 63 | Expression and purification of an engineered human endothelin receptor B in a monomeric form | 0.4 | 1 | Citations (PDF) |
| 64 | In vitro expression and analysis of the 826 human G protein-coupled receptors | 6.7 | 76 | Citations (PDF) |
| 65 | Native phasing of x-ray free-electron laser data for a G protein–coupled receptor | 8.2 | 102 | Citations (PDF) |
| 66 | Generic GPCR residue numbers – aligning topology maps while minding the gaps | 11.1 | 516 | Citations (PDF) |
| 67 | Structural basis for bifunctional peptide recognition at human δ-opioid receptor | 6.0 | 177 | Citations (PDF) |
| 68 | Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides | 2.0 | 16 | Citations (PDF) |
| 69 | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser | 31.8 | 805 | Citations (PDF) |
| 70 | Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information | 1.9 | 55 | Citations (PDF) |
| 71 | Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography | 23.8 | 377 | Citations (PDF) |
| 72 | Sodium Ion Binding Pocket Mutations and Adenosine A2A Receptor Function | 2.4 | 100 | Citations (PDF) |
| 73 | Two disparate ligand-binding sites in the human P2Y1 receptor | 31.8 | 364 | Citations (PDF) |
| 74 | Nucleotides Acting at P2Y Receptors: Connecting Structure and Function | 2.4 | 102 | Citations (PDF) |
| 75 | The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor | 2.5 | 77 | Citations (PDF) |
| 76 | Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR | 5.3 | 112 | Citations (PDF) |
| 77 | Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y receptor | 1.5 | 26 | Citations (PDF) |
| 78 | Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor*♦ | 1.3 | 184 | Citations (PDF) |
| 79 | Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y14 Receptor Antagonist Molecular Probes | 2.5 | 45 | Citations (PDF) |
| 80 | Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator | 26.5 | 523 | Citations (PDF) |
| 81 | Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography | 11.0 | 577 | Citations (PDF) |
| 82 | Structure of the human P2Y12 receptor in complex with an antithrombotic drug | 31.8 | 391 | Citations (PDF) |
| 83 | Allosteric sodium in class A GPCR signaling | 7.4 | 523 | Citations (PDF) |
| 84 | Molecular control of δ-opioid receptor signalling | 31.8 | 500 | Citations (PDF) |
| 85 | Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs | 11.0 | 245 | Citations (PDF) |
| 86 | Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges | 2.5 | 161 | Citations (PDF) |
| 87 | Agonist-bound structure of the human P2Y12 receptor | 31.8 | 342 | Citations (PDF) |
| 88 | Structure of the human glucagon class B G-protein-coupled receptor | 31.8 | 373 | Citations (PDF) |
| 89 | The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A2A Adenosine G Protein-Coupled Receptor | 2.5 | 143 | Citations (PDF) |
| 90 | Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists* | 1.3 | 66 | Citations (PDF) |
| 91 | Structure-Based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors | 2.4 | 87 | Citations (PDF) |
| 92 | Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCRCell, 2013, 155, 1258-1269 | 23.8 | 186 | Citations (PDF) |
| 93 | Structure-Function of the G Protein–Coupled Receptor Superfamily | 10.6 | 1,040 | Citations (PDF) |
| 94 | Structure of the human smoothened receptor bound to an antitumour agent | 31.8 | 445 | Citations (PDF) |
| 95 | Diversity and modularity of G protein-coupled receptor structures | 11.1 | 457 | Citations (PDF) |
| 96 | Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic | 31.8 | 457 | Citations (PDF) |
| 97 | Structure of the human κ-opioid receptor in complex with JDTic | 31.8 | 874 | Citations (PDF) |
| 98 | Optimization of Adenosine 5′-Carboxamide Derivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Design and Fragment Screening | 4.8 | 58 | Citations (PDF) |
| 99 | Evaluation of Molecular Modeling of Agonist Binding in Light of the Crystallographic Structure of an Agonist-Bound A2A Adenosine Receptor | 4.8 | 37 | Citations (PDF) |
| 100 | Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors | 2.5 | 485 | Citations (PDF) |
| 101 | The GPCR Network: a large-scale collaboration to determine human GPCR structure and function | 47.0 | 307 | Citations (PDF) |
| 102 | Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H1 Receptor | 4.8 | 204 | Citations (PDF) |
| 103 | Structure based prediction of subtype-selectivity for adenosine receptor antagonists | 3.1 | 84 | Citations (PDF) |
| 104 | Structure of an Agonist-Bound Human A2A Adenosine Receptor | 26.5 | 822 | Citations (PDF) |
| 105 | High Resolution Structure of the ba3 Cytochrome c Oxidase from Thermus thermophilus in a Lipidic Environment | 1.5 | 113 | Citations (PDF) |
| 106 | Status of GPCR Modeling and Docking as Reflected by Community-wide GPCR Dock 2010 Assessment | 2.5 | 278 | Citations (PDF) |
| 107 | Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX | 2.5 | 145 | Citations (PDF) |
| 108 | Structure of the human histamine H1 receptor complex with doxepin | 31.8 | 795 | Citations (PDF) |
| 109 | Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists | 4.8 | 241 | Citations (PDF) |
| 110 | GPCR 3D homology models for ligand screening: Lessons learned from blind predictions of adenosine A2a receptor complex† | 1.9 | 129 | Citations (PDF) |
| 111 | Ligand Binding and Subtype Selectivity of the Human A2A Adenosine ReceptorIDENTIFICATION AND CHARACTERIZATION OF ESSENTIAL AMINO ACID RESIDUES* | 1.3 | 89 | Citations (PDF) |
| 112 | SimiCon: a web tool for protein-ligand model comparison through calculation of equivalent atomic contacts. | 3.2 | 13 | Citations (PDF) |
| 113 | Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists | 26.5 | 1,763 | Citations (PDF) |
| 114 | Conserved Binding Mode of Human β2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography | 12.2 | 366 | Citations (PDF) |
| 115 | Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes | 1.8 | 118 | Citations (PDF) |
| 116 | Identifying conformational changes of the β2 adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators | 1.9 | 61 | Citations (PDF) |
| 117 | In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin | 1.9 | 43 | Citations (PDF) |
| 118 | Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches | 1.9 | 51 | Citations (PDF) |
| 119 | Tightness of random knotting | 1.6 | 119 | Citations (PDF) |
| 120 | Pulling chromatin fibers: computer simulations of direct physical micromanipulations | 3.0 | 89 | Citations (PDF) |
| 121 | Aminoglycoside binding in the major groove of duplex RNA: the thermodynamic and electrostatic forces that govern recognition | 3.0 | 66 | Citations (PDF) |
| 122 | Influence of nucleosome structure on the three-dimensional folding of idealized minichromosomes | 2.5 | 11 | Citations (PDF) |
| 123 | Geometry and Physics of Catenanes Applied to the Study of DNA Replication | 1.5 | 50 | Citations (PDF) |
| 124 | The effect of intrinsic curvature on conformational properties of circular DNA. | 1.5 | 32 | Citations (PDF) |
| 125 | Opposite effect of counterions on the persistence length of nicked and non-nicked DNA | 3.0 | 35 | Citations (PDF) |
| 126 | Properties of ideal composite knots | 31.8 | 78 | Citations (PDF) |
| 127 | Electrophoretic mobility of DNA knots | 31.8 | 184 | Citations (PDF) |
| 128 | Geometry and physics of knots | 31.8 | 254 | Citations (PDF) |
| 129 | Determination of DNA Persistence Length by Cryo-electron Microscopy. Separation of the Static and Dynamic Contributions to the Apparent Persistence Length of DNA | 3.0 | 244 | Citations (PDF) |
| 130 | Computational design of thermostabilizing point mutations for G protein-coupled receptors. | 1.0 | 73 | Citations (PDF) |
| 131 | Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site. | 1.0 | 66 | Citations (PDF) |
| 132 | Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells. | 1.0 | 55 | Citations (PDF) |
| 133 | Structure-based discovery of potent and selective melatonin receptor agonists. | 1.0 | 44 | Citations (PDF) |
| 134 | Exceptionally Potent Chiral Anandamide Analogs | 4.8 | 2 | Citations (PDF) |
| 135 | Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1 | 11.0 | 8 | Citations (PDF) |
| 136 | Navigating structure-based drug discovery with emerging innovations in physics- and knowledge-based approaches | 3.5 | 22 | Citations (PDF) |
| 137 | Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors | 1.8 | 2 | Citations (PDF) |
| 138 | PLATE-VS: a web server for protein-ligand assay curation and cross-target virtual screening datasets. | 11.2 | 2 | Citations (PDF) |
| 139 | Molecular mechanisms for subtype selectivity of kinin receptors' antagonists. | 11.0 | 0 | Citations (PDF) |
| 140 | A Ligand-Triggered Receptor Conformation Enables the Design of Selective Agonists for the Dopamine 3 Receptor (D3R) Using a Bitopic Strategy. | 5.5 | 1 | Citations (PDF) |
| 141 | V-SYNTHES2-the next generation tool for structure-based virtual screening of giga-scale chemical spaces. | 3.5 | 3 | Citations (PDF) |