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259 PR articles • 18,957 PR citations • Sorted by year • Download PDF (PDF by citations)
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1Introducing Metal–Organic Frameworks to Melt Electrowriting: Multifunctional Scaffolds with Controlled Microarchitecture for Tissue Engineering Applications17.024Citations (PDF)
2Potent Anticancer Activity of a Dinuclear Gold(I) bis‐<i>N</i>‐Heterocyclic Imine Complex Related to Thioredoxin Reductase Inhibition <i>in Vitro</i>
ChemPlusChem, 2024, 89,
2.77Citations (PDF)
3Metals in Cancer Research: Beyond Platinum Metallodrugs
ACS Central Science, 2024, 10, 242-250
9.292Citations (PDF)
4A graft-to strategy of poly(vinylphosphonates) on dopazide-coated gold nanoparticles using <i>in situ</i> catalyst activation
RSC Advances, 2024, 14, 8145-8149
4.43Citations (PDF)
5(SiFA)SeFe: A Hydrophilic Silicon-Based Fluoride Acceptor Enabling Versatile Peptidic Radiohybrid Tracers
Journal of Medicinal Chemistry, 2024, 67, 14077-14094
5.67Citations (PDF)
6Assembling a new generation of radiopharmaceuticals with supramolecular theranostics
Nature Reviews Chemistry, 2024, 8, 893-914
46.721Citations (PDF)
7PET Imaging of Self‐Assembled <sup>18</sup>F‐Labelled Pd<sub>2</sub>L<sub>4</sub> Metallacages for Anticancer Drug Delivery3.419Citations (PDF)
8Bioinorganic supramolecular coordination complexes and their biomedical applications
FEBS Letters, 2023, 597, 191-202
2.735Citations (PDF)
9Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems14.4152Citations (PDF)
10Elucidating the Multimodal Anticancer Mechanism of an Organometallic Terpyridine Platinum(II) N-Heterocyclic Carbene Complex against Triple-Negative Breast Cancer In Vitro and In Vivo
Journal of Medicinal Chemistry, 2023, 66, 3995-4008
5.624Citations (PDF)
11Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems
Angewandte Chemie, 2023, 135,
1.412Citations (PDF)
12Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks15.023Citations (PDF)
13Electrochemical Detection of Drugs via a Supramolecular Cucurbit[7]uril-Based Indicator Displacement Assay
ACS Sensors, 2023, 8, 2525-2532
8.516Citations (PDF)
14Exploring the Anticancer Activity of Tamoxifen-Based Metal Complexes Targeting Mitochondria
Journal of Medicinal Chemistry, 2023, 66, 9823-9841
5.635Citations (PDF)
15Synthesis of <sup>177</sup>Lu-Labeled, Somatostatin-2 Receptor-Targeted Metalla-Assemblies: Challenges in the Design of Supramolecular Radiotherapeutics
Inorganic Chemistry, 2023, 62, 20710-20720
4.68Citations (PDF)
16Application of Machine Learning Algorithms to Metadynamics for the Elucidation of the Binding Modes and Free Energy Landscape of Drug/Target Interactions: a Case Study3.410Citations (PDF)
17Beyond Metal-Arenes: Monocarbonyl Ruthenium(II) Catalysts for Transfer Hydrogenation Reactions in Water and in Cells
ACS Catalysis, 2023, 13, 10798-10823
12.416Citations (PDF)
18Seeing the invisible: Preparative strategies to visualise elusive molecules using mass spectrometry imaging11.26Citations (PDF)
19Bio-based and bio-inspired adhesives from animals and plants for biomedical applications
Materials Today Bio, 2022, 13, 100203
7.167Citations (PDF)
20Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases3.620Citations (PDF)
21Competitive profiling of ligandable cysteines in <i>Staphylococcus aureus</i> with an organogold compound
Chemical Communications, 2022, 58, 5526-5529
3.421Citations (PDF)
22Indenyl and Allyl Palladate Complexes Bearing<i>N</i>‐Heterocyclic Carbene Ligands: an Easily Accessible Class of New Anticancer Drug Candidates1.835Citations (PDF)
23Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies
Dalton Transactions, 2022, 51, 7476-7490
3.016Citations (PDF)
24Cyclodextrin metal–organic frameworks and derivatives: recent developments and applications
Chemical Society Reviews, 2022, 51, 5175-5213
37.8144Citations (PDF)
25Bottom‐up Synthesis of Water‐Soluble Gold Nanoparticles Stabilized by N‐Heterocyclic Carbenes: From Structural Characterization to Applications3.428Citations (PDF)
26Optimization of the Pharmacokinetic Profile of [99mTc]Tc-N4-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence
Pharmaceuticals, 2022, 15, 1133
4.46Citations (PDF)
27“Dynamical Docking” of Cyclic Dinuclear Au(I) Bis-N-heterocyclic Complexes Facilitates Their Binding to G-Quadruplexes
Inorganic Chemistry, 2022, 61, 20405-20423
4.615Citations (PDF)
28Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni3.17Citations (PDF)
29N-Heterocyclic carbenes as “smart” gold nanoparticle stabilizers: State-of-the art and perspectives for biomedical applications2.134Citations (PDF)
30Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management4.849Citations (PDF)
31Interfering with Metabolic Profile of Triple‐Negative Breast Cancers Using Rationally Designed Metformin Prodrugs
Angewandte Chemie, 2021, 133, 13517-13525
1.43Citations (PDF)
32The Beauty of Gold: Knowledge of Mechanisms Leads to Different Applications of Organogold Compounds in Medicine and Catalysis
Chemistry Letters, 2021, 50, 1516-1522
1.114Citations (PDF)
33Interfering with Metabolic Profile of Triple‐Negative Breast Cancers Using Rationally Designed Metformin Prodrugs14.464Citations (PDF)
34Host–Guest Interactions in a Metal–Organic Framework Isoreticular Series for Molecular Photocatalytic CO<sub>2</sub> Reduction14.4119Citations (PDF)
35An Organogold Compound as Potential Antimicrobial Agent against Drug‐Resistant Bacteria: Initial Mechanistic Insights
ChemMedChem, 2021, 16, 3060-3070
3.136Citations (PDF)
36Investigation of Solvatomorphism and Its Photophysical Implications for Archetypal Trinuclear Au3(1-Methylimidazolate)3
Molecules, 2021, 26, 4404
4.31Citations (PDF)
37C−C Cross‐Couplings from a Cyclometalated Au(III) CN Complex: Mechanistic Insights and Synthetic Developments
Chemistry - A European Journal, 2021, 27, 14322-14334
3.411Citations (PDF)
38Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations
Metallomics, 2021, 13,
2.68Citations (PDF)
39Bioconjugate Supramolecular Pd<sup>2+</sup> Metallacages Penetrate the Blood Brain Barrier <i>In Vitro</i> and <i>In Vivo</i>
Bioconjugate Chemistry, 2021, 32, 1399-1408
3.947Citations (PDF)
40Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands3.049Citations (PDF)
41Exploring the Reactivity and Biological Effects of Heteroleptic N‐Heterocyclic Carbene Gold(I)‐Alkynyl Complexes1.842Citations (PDF)
42Human red blood cell uptake and sequestration of arsenite and selenite: Evidence of seleno-bis(S-glutathionyl) arsinium ion formation in human cells
Biochemical Pharmacology, 2020, 180, 114141
5.210Citations (PDF)
43Insights into the Selectivity Mechanisms of Grapevine NIP Aquaporins4.513Citations (PDF)
44Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in <i>L. amazonensis</i> and <i>L. braziliensis in Vitro</i>
ChemMedChem, 2020, 15, 2146-2150
3.138Citations (PDF)
45An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells
Chemistry - A European Journal, 2020, 26, 15528-15537
3.463Citations (PDF)
46Exploring the Chemoselectivity towards Cysteine Arylation by Cyclometallated Au<sup>III</sup> Compounds: New Mechanistic Insights
ChemBioChem, 2020, 21, 3071-3076
2.631Citations (PDF)
47Gold compounds for catalysis and metal-mediated transformations in biological systems5.959Citations (PDF)
48Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver
Toxicology in Vitro, 2020, 65, 104800
2.745Citations (PDF)
49Carbon–Phosphorus Coupling from C^N Cyclometalated Au<sup>III</sup> Complexes
Chemistry - A European Journal, 2020, 26, 4226-4231
3.424Citations (PDF)
50Design Strategies and Medicinal Applications of Metal-Peptidic Bioconjugates
Bioconjugate Chemistry, 2020, 31, 1279-1288
3.952Citations (PDF)
51Targeted imaging of integrins in cancer tissues using photocleavable Ru(<scp>ii</scp>) polypyridine complexes as mass-tags
Chemical Communications, 2020, 56, 5941-5944
3.418Citations (PDF)
52Aquaporin-3 is involved in NLRP3-inflammasome activation contributing to the setting of inflammatory response5.646Citations (PDF)
53Aquaporin-driven hydrogen peroxide transport: a case of molecular mimicry?
RSC Chemical Biology, 2020, 1, 390-394
3.326Citations (PDF)
54Highly luminescent metallacages featuring bispyridyl ligands functionalised with BODIPY for imaging in cancer cells3.031Citations (PDF)
55<i>In My Element</i>: Gold
Chemistry - A European Journal, 2019, 25, 12234-12234
3.41Citations (PDF)
56The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor
Journal of Controlled Release, 2019, 296, 250-257
11.120Citations (PDF)
57Recent Developments of Supramolecular Metal-based Structures for Applications in Cancer Therapy and Imaging
Theranostics, 2019, 9, 3150-3169
11.5172Citations (PDF)
58Unveiling the Mechanisms of Aquaglyceroporin‐3 Water and Glycerol Permeation by Metadynamics
Chemistry - A European Journal, 2019, 25, 8713-8718
3.421Citations (PDF)
59Sperm selection with density gradient centrifugation and swim up: effect on DNA fragmentation in viable spermatozoa3.5115Citations (PDF)
60Cyclometalated Au<sup>III</sup> Complexes for Cysteine Arylation in Zinc Finger Protein Domains: towards Controlled Reductive Elimination
Chemistry - A European Journal, 2019, 25, 7628-7634
3.466Citations (PDF)
61Exo-Functionalized Metallacages as Host-Guest Systems for the Anticancer Drug Cisplatin3.622Citations (PDF)
62Copper Complex Nanoformulations Featuring Highly Promising Therapeutic Potential in Murine Melanoma Models
Nanomedicine, 2019, 14, 835-850
3.150Citations (PDF)
63Mediterranean, but not lacto-ovo-vegetarian, diet positively influence circulating progenitor cells for cardiovascular prevention: The CARDIVEG study3.48Citations (PDF)
64Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands
Toxicology Research, 2019, 8, 885-895
2.211Citations (PDF)
65Effects of a 3-month dietary intervention with a lacto-ovo-vegetarian diet on vitamin B12 levels in a group of omnivores: results from the CARDIVEG (Cardiovascular Prevention with Vegetarian Diet) study
British Journal of Nutrition, 2019, 121, 756-762
2.52Citations (PDF)
66Imaging of protein distribution in tissues using mass spectrometry: An interdisciplinary challenge11.249Citations (PDF)
67Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis3.435Citations (PDF)
68Insights into the Mechanisms of Aquaporin-3 Inhibition by Gold(III) Complexes: the Importance of Non-Coordinative Adduct Formation
Inorganic Chemistry, 2019, 58, 2140-2148
4.636Citations (PDF)
69Anticancer Gold(III) Peptidomimetics: From Synthesis to in vitro and ex vivo Biological Evaluations
ChemMedChem, 2018, 13, 1131-1145
3.128Citations (PDF)
70Selective targeting of PARP-1 zinc finger recognition domains with Au(<scp>iii</scp>) organometallics
Chemical Communications, 2018, 54, 611-614
3.451Citations (PDF)
71Gold(III) Pyridine-Benzimidazole Complexes as Aquaglyceroporin Inhibitors and Antiproliferative Agents
Inorganics, 2018, 6, 123
2.815Citations (PDF)
72Molecular Basis of Aquaporin-7 Permeability Regulation by pH
Cells, 2018, 7, 207
4.836Citations (PDF)
73New Variations on the Theme of Gold(III) C<sup>∧</sup>N<sup>∧</sup>N Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization
Inorganic Chemistry, 2018, 57, 14852-14865
4.635Citations (PDF)
74Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin3.621Citations (PDF)
75Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin
Bioconjugate Chemistry, 2018, 29, 3856-3865
3.954Citations (PDF)
76Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents
Metallomics, 2018, 10, 696-712
2.666Citations (PDF)
77On the Mechanism of Gold/NHC Compounds Binding to DNA G‐Quadruplexes: Combined Metadynamics and Biophysical Methods
Angewandte Chemie, 2018, 130, 14732-14736
1.416Citations (PDF)
78On the Mechanism of Gold/NHC Compounds Binding to DNA G‐Quadruplexes: Combined Metadynamics and Biophysical Methods14.469Citations (PDF)
79Cyclometalated Complexes of Platinum and Gold with Biological Properties: State-of-the-Art and Future Perspectives
Current Medicinal Chemistry, 2018, 25, 437-461
2.665Citations (PDF)
80Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications
Chemical Communications, 2017, 53, 1405-1408
3.438Citations (PDF)
81Nonconventional <i>trans</i>‐Platinum Complexes Functionalized with RDG Peptides: Chemical and Cytototoxicity Studies1.811Citations (PDF)
82Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: Current frontiers and perspectives
Coordination Chemistry Reviews, 2017, 352, 432-460
23.2110Citations (PDF)
83The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods
Chemical Communications, 2017, 53, 3830-3833
3.454Citations (PDF)
84Mechanistic Insights into Gold Organometallic Compounds and their Biomedical Applications
Chimia, 2017, 71, 92
0.838Citations (PDF)
85A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages3.523Citations (PDF)
86A Multi‐Level Theoretical Study to Disclose the Binding Mechanisms of Gold(III)–Bipyridyl Compounds as Selective Aquaglyceroporin Inhibitors
Chemistry - A European Journal, 2017, 23, 13802-13813
3.434Citations (PDF)
87Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes2.637Citations (PDF)
88On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent
Metallomics, 2017, 9, 1786-1795
2.625Citations (PDF)
89Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches
Inorganic Chemistry, 2017, 56, 14237-14250
4.699Citations (PDF)
90Functionalization of Ruthenium(II) Terpyridine Complexes with Cyclic RGD Peptides To Target Integrin Receptors in Cancer Cells1.827Citations (PDF)
91Aquaporin modulators: a patent review (2010–2015)4.055Citations (PDF)
92Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials2.8846Citations (PDF)
93Anticancer Gold <i>N</i>‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study
ChemMedChem, 2017, 12, 1429-1435
3.160Citations (PDF)
94Nanoformulations of a Potent copper-based Aquaporin Inhibitor With Cytotoxic Effect Against Cancer Cells
Nanomedicine, 2016, 11, 1817-1830
3.157Citations (PDF)
95Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells3.05Citations (PDF)
96Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin
Chemistry - A European Journal, 2016, 22, 2253-2256
3.4140Citations (PDF)
97Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G‐Quadruplex: a Joint ESI MS and XRD Investigation
Angewandte Chemie, 2016, 128, 4328-4331
1.447Citations (PDF)
98Supramolecular exo-functionalized palladium cages: fluorescent properties and biological activity
Dalton Transactions, 2016, 45, 8556-8565
3.054Citations (PDF)
99Toward anticancer gold-based compounds targeting PARP-1: a new case study
RSC Advances, 2016, 6, 79147-79152
4.413Citations (PDF)
100Self‐Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity1.852Citations (PDF)
101Self-assembly of highly luminescent heteronuclear coordination cages
Dalton Transactions, 2016, 45, 12297-12300
3.052Citations (PDF)
102Transition-metal norharmane compounds as possible cytotoxic agents: New insights based on a coordination chemistry perspective3.027Citations (PDF)
103Ferrocenyl‐Coupled N‐Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs
Chemistry - A European Journal, 2016, 22, 18953-18962
3.473Citations (PDF)
104Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G‐Quadruplex: a Joint ESI MS and XRD Investigation14.496Citations (PDF)
105New Luminescent Polynuclear Metal Complexes with Anticancer Properties: Toward Structure–Activity Relationships
Inorganic Chemistry, 2016, 55, 2544-2557
4.675Citations (PDF)
106Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects
Inorganic Chemistry, 2016, 55, 4248-4259
4.656Citations (PDF)
107Structure and biological activities of metal complexes of flumequine
RSC Advances, 2016, 6, 19555-19570
4.427Citations (PDF)
108Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?
Molecular BioSystems, 2016, 12, 1564-1573
3.236Citations (PDF)
109The inhibition of glycerol permeation through aquaglyceroporin-3 induced by mercury(II): A molecular dynamics study3.029Citations (PDF)
110Exploring the potential of gold(<scp>iii</scp>) cyclometallated compounds as cytotoxic agents: variations on the C^N theme
Dalton Transactions, 2015, 44, 11911-11918
3.068Citations (PDF)
111Improved Synthesis of <i>N</i>-Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity
Journal of Medicinal Chemistry, 2015, 58, 2015-2024
5.682Citations (PDF)
112Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents2.5106Citations (PDF)
113Correlation between the Stereochemistry and Bioactivity in Octahedral Rhodium Prolinato Complexes
Inorganic Chemistry, 2015, 54, 8111-8120
4.617Citations (PDF)
114Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group
Journal of Medicinal Chemistry, 2015, 58, 6283-6292
5.682Citations (PDF)
115Reactivity of Cys4 Zinc Finger Domains with Gold(III) Complexes: Insights into the Formation of “Gold Fingers”
Inorganic Chemistry, 2015, 54, 4104-4113
4.641Citations (PDF)
116Gold finger formation studied by high-resolution mass spectrometry and in silico methods
Chemical Communications, 2015, 51, 1612-1615
3.444Citations (PDF)
117Insights into the strong in-vitro anticancer effects for bis(triphenylphosphane)iminium compounds having perchlorate, tetrafluoridoborate and bis(chlorido)argentate anions3.014Citations (PDF)
118Gold(I) N-heterocyclic carbene complexes with an “activable” ester moiety: Possible biological applications2.139Citations (PDF)
119A Gold Coordination Compound as a Chemical Probe to Unravel Aquaporin‐7 Function
ChemBioChem, 2014, 15, 1487-1494
2.643Citations (PDF)
120Functional Inhibition of Aquaporin-3 With a Gold-Based Compound Induces Blockage of Cell Proliferation
Journal of Cellular Physiology, 2014, 229, 1787-1801
4.267Citations (PDF)
121Cytotoxic Gold(I) N‐heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors
ChemMedChem, 2014, 9, 1205-1210
3.183Citations (PDF)
122Self-assembled M2L4 coordination cages: Synthesis and potential applications23.2241Citations (PDF)
123Nitrate as a probe of cytochrome c surface: Crystallographic identification of crucial “hot spots” for protein–protein recognition3.011Citations (PDF)
124Caffeine-Based Gold(I) <i>N</i>-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties
Inorganic Chemistry, 2014, 53, 2296-2303
4.6230Citations (PDF)
125Gold(<scp>i</scp>) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro
MedChemComm, 2014, 5, 1418-1422
4.611Citations (PDF)
126Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents6.448Citations (PDF)
127New Gold(I) Organometallic Compounds with Biological Activity in Cancer Cells1.887Citations (PDF)
128Gold compounds as aquaporin inhibitors: new opportunities for therapy and imaging
MedChemComm, 2014, 5, 1444-1453
4.638Citations (PDF)
129New heteronuclear gold(I)–platinum(II) complexes with cytotoxic properties: Are two metals better than one?3.070Citations (PDF)
130Light-stable bis(norharmane)silver(I) compounds: Synthesis, characterization and antiproliferative effects in cancer cells3.029Citations (PDF)
131Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals23.222Citations (PDF)
132Cellular Transport Mechanisms of Cytotoxic Metallodrugs: An Overview beyond Cisplatin
Molecules, 2014, 19, 15584-15610
4.3176Citations (PDF)
133Aquaporin Inhibition by Gold(III) Compounds: New Insights
ChemMedChem, 2013, 8, 1086-1092
3.185Citations (PDF)
134A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin3.048Citations (PDF)
135BODIPY–phosphane as a versatile tool for easy access to new metal-based theranostics
Dalton Transactions, 2013, 42, 6102-6109
3.057Citations (PDF)
136Fluorescent silver(i) and gold(i)–N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights
Metallomics, 2013, 5, 1006
2.6130Citations (PDF)
137Emerging protein targets for metal-based pharmaceutical agents: An update
Coordination Chemistry Reviews, 2013, 257, 2689-2704
23.2138Citations (PDF)
138Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs
Chemical Society Reviews, 2013, 42, 6186
37.8146Citations (PDF)
139Potential Anticancer Heterometallic Fe–Au and Fe–Pd Agents: Initial Mechanistic Insights
Journal of Medicinal Chemistry, 2013, 56, 5806-5818
5.693Citations (PDF)
140The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics3.038Citations (PDF)
141The Formation of Oxytocin Dimers is Suppressed by the Zinc-Aspartate-Oxytocin Complex3.216Citations (PDF)
142Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes3.627Citations (PDF)
143Next-Generation Anticancer Metallodrugs3.0203Citations (PDF)
144Gold(I) Carbene Complexes Causing Thioredoxin <b>1</b> and Thioredoxin <b>2</b> Oxidation as Potential Anticancer Agents
Journal of Medicinal Chemistry, 2012, 55, 5518-5528
5.6244Citations (PDF)
145Reactivity and Biological Properties of a Series of Cytotoxic PtI<sub>2</sub>(amine)<sub>2</sub> Complexes, Either <i>cis</i> or <i>trans</i> Configured
Inorganic Chemistry, 2012, 51, 1717-1726
4.639Citations (PDF)
146Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1
Dalton Transactions, 2012, 41, 3287
3.065Citations (PDF)
147Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?
Chemical Science, 2012, 3, 3135
7.1183Citations (PDF)
148Exploring the mechanisms of metal­based pharmacological agents via an integrated approach3.045Citations (PDF)
149Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-Based Compound
PLoS ONE, 2012, 7, e37435
2.4122Citations (PDF)
150Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays
MedChemComm, 2011, 2, 50-54
4.6104Citations (PDF)
151Conjugation of Organoruthenium(II) 3-(1<i>H</i>-Benzimidazol-2-yl)pyrazolo[3,4-<i>b</i>]pyridines and Indolo[3,2-<i>d</i>]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells
Inorganic Chemistry, 2011, 50, 12669-12679
4.656Citations (PDF)
152Multinuclear Cytotoxic Metallodrugs: Physicochemical Characterization and Biological Properties of Novel Heteronuclear Gold–Titanium Complexes
Inorganic Chemistry, 2011, 50, 9472-9480
4.685Citations (PDF)
153Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity
Journal of Medicinal Chemistry, 2011, 54, 3895-3902
5.6237Citations (PDF)
154Metal-Based Inhibition of Poly(ADP-ribose) Polymerase − The Guardian Angel of DNA
Journal of Medicinal Chemistry, 2011, 54, 2196-2206
5.6144Citations (PDF)
155Thiolato gold(i) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties
Dalton Transactions, 2011, 40, 10927
3.055Citations (PDF)
156Mechanistic studies on two dinuclear organogold(iii) compounds showing appreciable antiproliferative properties and a high redox stability
Metallomics, 2011, 3, 1318
2.630Citations (PDF)
157Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(ii) compounds with sulfur and phosphorus donors
Dalton Transactions, 2011, 40, 2006
3.029Citations (PDF)
158Organometallic ruthenium-based antitumor compounds with novel modes of action2.1344Citations (PDF)
159Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties2.118Citations (PDF)
160Molecular Mechanisms and Proposed Targets for Selected Anticancer Gold Compounds3.0190Citations (PDF)
161Trace Copper(II) or Zinc(II) Ions Drastically Modify the Aggregation Behavior of Amyloid-β1–42: An AFM Study
Journal of Alzheimer's Disease, 2010, 19, 1323-1329
2.686Citations (PDF)
162Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands
ChemMedChem, 2010, 5, 96-102
3.1121Citations (PDF)
163Proteins as Possible Targets for Cytotoxic <i>trans</i>‐Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm
ChemMedChem, 2010, 5, 1335-1343
3.125Citations (PDF)
164Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies
Medicinal Research Reviews, 2010, 30, 550-580
13.8476Citations (PDF)
165Trans–cis–cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B3.016Citations (PDF)
166Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand2.1125Citations (PDF)
167Reactivity of anticancer metallodrugs with serum proteins: new insights from size exclusion chromatography-ICP-MS and ESI-MS3.198Citations (PDF)
168Antiproliferative Activity of Gold(I) Alkyne Complexes Containing Water-Soluble Phosphane Ligands
Organometallics, 2010, 29, 2596-2603
2.9102Citations (PDF)
169Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel “Rule-Breaker” Iodidoplatinum(II) Complex3.433Citations (PDF)
170Synthesis, characterisation and biological properties of gold(iii) compounds with modified bipyridine and bipyridylamine ligands
Dalton Transactions, 2010, 39, 2239
3.084Citations (PDF)
171Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT
Dalton Transactions, 2010, 39, 5556
3.085Citations (PDF)
172The X‐ray Structure of the Adduct between NAMI‐A and Carbonic Anhydrase Provides Insights into the Reactivity of this Metallodrug with Proteins
ChemMedChem, 2010, 5, 1989-1994
3.144Citations (PDF)
173[Au<sub>2</sub>(phen<sup>2Me</sup>)<sub>2</sub>(μ<b>-</b>O)<sub>2</sub>](PF<sub>6</sub>)<sub>2</sub>, a Novel Dinuclear Gold(III) Complex Showing Excellent Antiproliferative Properties3.483Citations (PDF)
174Development of Bimetallic Titanocene−Ruthenium−Arene Complexes As Anticancer Agents: Relationships between Structural and Biological Properties
Journal of Medicinal Chemistry, 2010, 53, 6923-6933
5.697Citations (PDF)
175Solution Behaviour and Biomolecular Interactions of Two Cytotoxic <i>trans</i>‐Platinum(II) Complexes Bearing Aliphatic Amine Ligands
Chemistry - A European Journal, 2009, 15, 9139-9146
3.423Citations (PDF)
176Exploring metallodrug–protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound2.5105Citations (PDF)
177Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study2.5128Citations (PDF)
178Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials3.031Citations (PDF)
179Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs
Coordination Chemistry Reviews, 2009, 253, 1692-1707
23.2571Citations (PDF)
180Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action
Metallomics, 2009, 1, 434
2.664Citations (PDF)
181Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles
Dalton Transactions, 2009, , 10731
3.068Citations (PDF)
182Clioquinol Decreases Amyloid-β Burden and Reduces Working Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease2.6121Citations (PDF)
183Peculiar mechanistic and structural features of the carboplatin–cytochrome c system revealed by ESI-MS analysis2.535Citations (PDF)
184The Influence of Auranofin, a Clinically Established Antiarthritic Gold Drug, on Bone Metabolism: Analysis of Its Effects on Human Multipotent Adipose‐Derived Stem Cells, Taken as a Model
Chemistry and Biodiversity, 2008, 5, 1513-1520
2.312Citations (PDF)
185Gold(III) compounds as anticancer agents: Relevance of gold–protein interactions for their mechanism of action3.0264Citations (PDF)
186Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: New insights from X-ray diffraction and mass spectrometry studies3.084Citations (PDF)
187Stability of an organometallic ruthenium–ubiquitin adduct in the presence of glutathione: Relevance to antitumour activity
Journal of Inorganic Biochemistry, 2008, 102, 2136-2141
3.063Citations (PDF)
188New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects <i>in vitro</i>: Mechanistic and pharmacological implications
FEBS Letters, 2008, 582, 844-847
2.7161Citations (PDF)
189Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds
Journal of Medicinal Chemistry, 2008, 51, 6773-6781
5.6269Citations (PDF)
190Structural Characterization, Solution Studies, and DFT Calculations on a Series of Binuclear Gold(III) Oxo Complexes: Relationships to Biological Properties
Inorganic Chemistry, 2008, 47, 2368-2379
4.6105Citations (PDF)
191Potential pathogenic role of β-amyloid1–42–aluminum complex in Alzheimer's disease2.779Citations (PDF)
192A multi-technique approach to predicting the molecular structure of cuprizone in the gas phase and in the crystalline state
CrystEngComm, 2008, ,
2.42Citations (PDF)
193Exploiting Soft and Hard X-Ray Absorption Spectroscopy to Characterize Metallodrug/Protein Interactions: the Binding of [<i>trans</i>-RuCl<sub>4</sub>(Im)(dimethylsulfoxide)][ImH] (Im = imidazole) to Bovine Serum Albumin
Inorganic Chemistry, 2008, 47, 8629-8634
4.651Citations (PDF)
194Antiplasmodial Effects of a few Selected Natural Flavonoids and their Modulation of Artemisinin Activity0.69Citations (PDF)
195Mass spectrometric analysis of ubiquitin–platinum interactions of leading anticancer drugs: MALDI versus ESI3.193Citations (PDF)
196Insights into the Molecular Mechanisms of Protein Platination from a Case Study:  The Reaction of Anticancer Platinum(II) Iminoethers with Horse Heart Cytochrome c
Biochemistry, 2007, 46, 12220-12230
2.452Citations (PDF)
197Antimalarial properties of green tea2.168Citations (PDF)
198ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme
Chemical Communications, 2007, , 156-158
3.4142Citations (PDF)
199Unravelling the chemical nature of copper cuprizone
Dalton Transactions, 2007, , 2112
3.057Citations (PDF)
200New Copper(II)/Cyclic Tetrapeptide System That Easily Oxidizes to Copper(III) under Atmospheric Oxygen
Inorganic Chemistry, 2007, 46, 10038-10040
4.629Citations (PDF)
201fac-{Ru(CO)3}2+-Core Complexes and Design of Metal-Based Drugs. Synthesis, Structure, and Reactivity of Ru−Thiazole Derivative with Serum Proteins and Absorption−Release Studies with Acryloyl and Silica Hydrogels as Carriers in Physiological Media
Inorganic Chemistry, 2007, 46, 79-92
4.638Citations (PDF)
202Activity of Rat Cytosolic Thioredoxin Reductase Is Strongly Decreased bytrans-[Bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]:  First Report of Relevant Thioredoxin Reductase Inhibition for a Ruthenium Compound
Journal of Medicinal Chemistry, 2007, 50, 5871-5874
5.653Citations (PDF)
203ESI–MS Characterisation of Protein Adducts of Anticancer Ruthenium(II)-Arene PTA (RAPTA) Complexes
ChemMedChem, 2007, 2, 631-635
3.188Citations (PDF)
204DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques
Biophysical Chemistry, 2007, 127, 213-220
2.138Citations (PDF)
205Gold(III) compounds as anticancer drugs
Gold Bulletin, 2007, 40, 73-81
0.8137Citations (PDF)
206Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c2.549Citations (PDF)
207Structural and Solution Chemistry, Antiproliferative Effects, and DNA and Protein Binding Properties of a Series of Dinuclear Gold(III) Compounds with Bipyridyl Ligands
Journal of Medicinal Chemistry, 2006, 49, 5524-5531
5.6191Citations (PDF)
208The reaction of artemisinins with hemoglobin: A unified picture2.666Citations (PDF)
209Structural Investigation of Cisplatin–Protein Interactions: Selective Platination of His19 in a Cuprozinc Superoxide Dismutase14.4107Citations (PDF)
210Exploring Metallodrug–Protein Interactions by ESI Mass Spectrometry: The Reaction of Anticancer Platinum Drugs with Horse Heart Cytochrome c
ChemMedChem, 2006, 1, 413-417
3.192Citations (PDF)
211Structural Investigation of Cisplatin–Protein Interactions: Selective Platination of His19 in a Cuprozinc Superoxide Dismutase
Angewandte Chemie, 2006, 118, 1289-1291
1.45Citations (PDF)
212Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II2.141Citations (PDF)
213Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies2.1186Citations (PDF)
214Carbonic anhydrase inhibitors: Design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma2.128Citations (PDF)
215Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides5.221Citations (PDF)
216Carbonic Anhydrase Inhibitors:  Synthesis and Inhibition of Cytosolic/Membrane-Associated Carbonic Anhydrase Isozymes I, II, and IX with Sulfonamides Incorporating Hydrazino Moieties
Journal of Medicinal Chemistry, 2005, 48, 2121-2125
5.672Citations (PDF)
217Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family
Journal of Biological Chemistry, 2004, 279, 2719-2727
2.2227Citations (PDF)
218COX-2 Selective Inhibitors, Carbonic Anhydrase Inhibition and Anticancer Properties of Sulfonamides Belonging to This Class of Pharmacological Agents2.6138Citations (PDF)
219Designing of Novel Carbonic Anhydrase Inhibitors and Activators1.2141Citations (PDF)
220New Developments on Thromboxane and Prostacyclin Modulators Part I: Thromboxane Modulators
Current Medicinal Chemistry, 2004, 11, 1223-1241
2.678Citations (PDF)
221Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX2.1261Citations (PDF)
222Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase2.1149Citations (PDF)
223Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides2.186Citations (PDF)
224Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-α-d-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits2.170Citations (PDF)
225Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride2.173Citations (PDF)
226Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX2.1152Citations (PDF)
227Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide2.149Citations (PDF)
228Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design2.138Citations (PDF)
229Carbonic Anhydrase Inhibitors: Aliphatic N-phosphorylated Sulfamates--A Novel Zinc-anchoring Group Leading to Nanomolar Inhibitors5.211Citations (PDF)
230Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib:  New Pharmacological Opportunities Due to Related Binding Site Recognition5.6443Citations (PDF)
231Carbonic Anhydrase Inhibitors:  Synthesis and Topical Intraocular Pressure Lowering Effects of Fluorine-Containing Inhibitors Devoid of Enhanced Reactivity
Journal of Medicinal Chemistry, 2004, 47, 2796-2804
5.639Citations (PDF)
232Carbonic Anhydrase Inhibitors:  The First On-Resin Screening of a 4-Sulfamoylphenylthiourea Library
Journal of Medicinal Chemistry, 2004, 47, 5224-5229
5.648Citations (PDF)
233Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH
FEBS Letters, 2004, 577, 439-445
2.7647Citations (PDF)
234Carbonic anhydrase inhibitors
Medicinal Research Reviews, 2003, 23, 146-189
13.81,188Citations (PDF)
235Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents
Medicinal Research Reviews, 2003, 23, 535-558
13.8428Citations (PDF)
236Carbonic anhydrase inhibitors2.185Citations (PDF)
237Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV2.1228Citations (PDF)
238Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II2.131Citations (PDF)
239Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide—two heads are better than one?2.136Citations (PDF)
240Carbonic anhydrase inhibitors: Topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide2.134Citations (PDF)
241Predicting bone mineral density of postmenopausal healthy and cirrhotic Italian women using anthropometric variables
Digestive and Liver Disease, 2003, 35, 881-887
2.47Citations (PDF)
242Carbonic Anhydrase Inhibitors:  Inhibition of Transmembrane, Tumor-Associated Isozyme IX, and Cytosolic Isozymes I and II with Aliphatic Sulfamates
Journal of Medicinal Chemistry, 2003, 46, 5471-5477
5.679Citations (PDF)
243Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Tumor-Associated Isozyme IX with Sulfamates Including EMATE Also Acting as Steroid Sulfatase Inhibitors
Journal of Medicinal Chemistry, 2003, 46, 2197-2204
5.6141Citations (PDF)
244Carbonic Anhydrase Inhibitors: X-ray Crystallographic Structure of the Adduct of Human Isozyme II with the Perfluorobenzoyl Analogue of Methazolamide. Implications for the Drug Design of Fluorinated Inhibitors5.250Citations (PDF)
245Targeting Cysteine Residues of Biomolecules: New Approaches for the Design of Antiviral and Anticancer Drugs
Current Medicinal Chemistry, 2002, 9, 1167-1185
2.656Citations (PDF)
246Sulfonamides and Sulfonylated Derivatives as Anticancer Agents2.5276Citations (PDF)
247Carbonic Anhydrase Inhibitors With Strong Topical Antiglaucoma Properties Incorporating a 4-(2-amino-pyrimidin-4-yl-amino)-benzenesulfonamide Scaffold5.215Citations (PDF)
248Carbonic Anhydrase Inhibitors: Synthesis of Water Soluble Sulfonamides Incorporating a 4-sulfamoylphenylmethylthiourea Scaffold, with Potent Intraocular Pressure Lowering Properties5.235Citations (PDF)
249Cysteine-modifying agents: a possible approach for effective anticancer and antiviral drugs.8.834Citations (PDF)
250Cyclodextrin Complexes of Sulfonamide Carbonic Anhydrase IOnhibitors As Long‐lasting Topically Acting Antiglaucoma Agents3.217Citations (PDF)
251Carbonic Anhydrase Inhibitors: Synthesis and Inhibition Against Isozymes I, II and IV of Topically Acting Antiglaucoma Sulfonamides Incorporating<i>cis</i>-5-Norbornene-<i>endo</i>-3-Carboxy-2-Carboxamido Moieties0.58Citations (PDF)
252Interactions of two cytotoxic organotin(IV) compounds with calf thymus DNA3.052Citations (PDF)
253Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties2.162Citations (PDF)
254Synthesis, molecular structure and solution chemistry of the iridium(III) complex imidazolium [trans(bisimidazole)tetrachloro iridate(III)] (IRIM)
Inorganica Chimica Acta, 2001, 312, 74-80
2.840Citations (PDF)
255Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions2.668Citations (PDF)
256Effects of two representative antitumor ruthenium(III) complexes on thermal denaturation profiles of DNA
Inorganica Chimica Acta, 2000, 303, 283-286
2.821Citations (PDF)
257DNA as a Possible Target for Antitumor Ruthenium(III) Complexes2.9117Citations (PDF)
258Formation of Supramolecular Structures between DNA and Starburst Dendrimers Studied by EPR, CD, UV, and Melting Profiles
Macromolecules, 2000, 33, 7842-7851
5.0125Citations (PDF)
259Carbonic Anhydrase Inhibitors:  Water-Soluble 4-Sulfamoylphenylthioureas as Topical Intraocular Pressure-Lowering Agents with Long-Lasting Effects
Journal of Medicinal Chemistry, 2000, 43, 4884-4892
5.6145Citations (PDF)