| 1 | Netrin-1 signaling pathway mechanisms in neurodegenerative diseases | 5.3 | 12 | Citations (PDF) |
| 2 | Positron emission tomography tracers for synucleinopathies | 14.1 | 22 | Citations (PDF) |
| 3 | Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease | 36.3 | 62 | Citations (PDF) |
| 4 | Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT | 12.6 | 0 | Citations (PDF) |
| 5 | Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition | 14.1 | 3 | Citations (PDF) |
| 6 | Development of Positron Emission Tomography Radiotracers for Imaging α-Synuclein Aggregates | 4.6 | 6 | Citations (PDF) |
| 7 | Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo | 1.1 | 1 | Citations (PDF) |
| 8 | Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer’s disease | 7.8 | 24 | Citations (PDF) |
| 9 | Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies | 12.5 | 76 | Citations (PDF) |
| 10 | Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson’s and Alzheimer’s disease co-pathology and behavior impairmentsNeuron, 2024, 112, 3585-3601.e5 | 11.0 | 64 | Citations (PDF) |
| 11 | Keqiang Ye: The C/EBPb/AEP pathway is the key driver for Alzheimer's disease (AD) and Parkinson's disease (PD) pathogenesis and its specific inhibitor attenuates AD/PD pathologies 2024, 1, 26-28 | | 1 | Citations (PDF) |
| 12 | C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain | 7.0 | 63 | Citations (PDF) |
| 13 | C/EBPβ/AEP Signaling Drives Alzheimer’s Disease Pathogenesis | 4.1 | 31 | Citations (PDF) |
| 14 | Zein-Based Nanoparticles Improve the Therapeutic Efficacy of a TrkB Agonist toward Alzheimer’s Disease | 3.7 | 12 | Citations (PDF) |
| 15 | Bacteroides Fragilis in the gut microbiomes of Alzheimer’s disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice | 13.7 | 99 | Citations (PDF) |
| 16 | FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice | 13.7 | 48 | Citations (PDF) |
| 17 | Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease | 32.9 | 114 | Citations (PDF) |
| 18 | Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice | 5.4 | 17 | Citations (PDF) |
| 19 | Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice | 13.7 | 104 | Citations (PDF) |
| 20 | Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer’s disease pathology in a mouse model | 5.9 | 43 | Citations (PDF) |
| 21 | UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease | 12.6 | 23 | Citations (PDF) |
| 22 | Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation | 16.8 | 427 | Citations (PDF) |
| 23 | FSH blockade improves cognition in mice with Alzheimer’s disease | 37.9 | 298 | Citations (PDF) |
| 24 | Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation | 8.8 | 47 | Citations (PDF) |
| 25 | Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression | 10.9 | 39 | Citations (PDF) |
| 26 | Oral Treatments With the TrkB Ligand Prodrug, R13, Promote Enhanced Axon Regeneration Following Peripheral Nerve Injury | 3.4 | 7 | Citations (PDF) |
| 27 | A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease | 6.8 | 25 | Citations (PDF) |
| 28 | C/EBPβ/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer’s disease | 7.8 | 21 | Citations (PDF) |
| 29 | High-fat diet-induced diabetes couples to Alzheimer’s disease through inflammation-activated C/EBPβ/AEP pathway | 7.8 | 70 | Citations (PDF) |
| 30 | Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase | 6.0 | 40 | Citations (PDF) |
| 31 | Why Women Are Predisposed to Alzheimer’s Disease | 0.0 | 0 | Citations (PDF) |
| 32 | A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin | 13.7 | 42 | Citations (PDF) |
| 33 | Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson’s disease | 7.8 | 22 | Citations (PDF) |
| 34 | BDNF and Netrin-1 repression by C/EBPβ in the gut triggers Parkinson’s disease pathologies, associated with constipation and motor dysfunctions | 5.9 | 50 | Citations (PDF) |
| 35 | Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice | 5.9 | 25 | Citations (PDF) |
| 36 | Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies | 10.9 | 40 | Citations (PDF) |
| 37 | A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer’s disease pathologiesBrain, 2021, 144, 1833-1852 | 8.4 | 38 | Citations (PDF) |
| 38 | ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer’s disease | 9.1 | 43 | Citations (PDF) |
| 39 | Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase | 3.7 | 41 | Citations (PDF) |
| 40 | Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer’s disease pathogenesis | 7.5 | 31 | Citations (PDF) |
| 41 | C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis | 1.9 | 29 | Citations (PDF) |
| 42 | Netrin-1/receptors regulate the pathogenesis in Parkinson’s diseases | 2.5 | 4 | Citations (PDF) |
| 43 | Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease | 5.1 | 17 | Citations (PDF) |
| 44 | Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease | 7.3 | 127 | Citations (PDF) |
| 45 | ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer’s disease | 5.9 | 48 | Citations (PDF) |
| 46 | Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease | 4.3 | 47 | Citations (PDF) |
| 47 | Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes | 6.3 | 23 | Citations (PDF) |
| 48 | A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer’s disease | 5.9 | 13 | Citations (PDF) |
| 49 | Mitochondrial dysfunction triggers the pathogenesis of Parkinson’s disease in neuronal C/EBPβ transgenic mice | 7.8 | 47 | Citations (PDF) |
| 50 | Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer’s disease | 5.9 | 20 | Citations (PDF) |
| 51 | Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features | 7.3 | 70 | Citations (PDF) |
| 52 | Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson’s Disease | 3.9 | 12 | Citations (PDF) |
| 53 | Asparagine Endopeptidase (δ Secretase), an Enzyme Implicated in Alzheimer’s Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral NervesENeuro, 2021, 8, ENEURO.0155-20.2020 | 2.1 | 8 | Citations (PDF) |
| 54 | δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities | 12.5 | 97 | Citations (PDF) |
| 55 | Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathologyBrain, 2020, 143, 650-660 | 8.4 | 93 | Citations (PDF) |
| 56 | Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer’s disease pathology | 5.9 | 75 | Citations (PDF) |
| 57 | Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma | 24.1 | 55 | Citations (PDF) |
| 58 | TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies | 7.8 | 35 | Citations (PDF) |
| 59 | Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model | 10.9 | 194 | Citations (PDF) |
| 60 | Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease | 11.3 | 40 | Citations (PDF) |
| 61 | Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson’s disease | 7.5 | 56 | Citations (PDF) |
| 62 | C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer’s disease | 7.8 | 63 | Citations (PDF) |
| 63 | Delta-secretase triggers Alzheimer’s disease pathologies in wild-type hAPP/hMAPT double transgenic mice | 8.5 | 15 | Citations (PDF) |
| 64 | C/EBPβ mediates NQO1 and GSTP1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation | 10.8 | 45 | Citations (PDF) |
| 65 | C/EBPβ/δ-secretase signaling mediates Parkinson’s disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB | 7.8 | 37 | Citations (PDF) |
| 66 | Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus | 10.6 | 110 | Citations (PDF) |
| 67 | Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease | 3.7 | 81 | Citations (PDF) |
| 68 | Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease | 6.3 | 220 | Citations (PDF) |
| 69 | Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist | 3.4 | 43 | Citations (PDF) |
| 70 | Tau accumulation triggers
STAT
1‐dependent memory deficits by suppressing
NMDA
receptor expression | 5.2 | 69 | Citations (PDF) |
| 71 | Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies | 7.5 | 63 | Citations (PDF) |
| 72 | Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation | 8.5 | 29 | Citations (PDF) |
| 73 | Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control | 7.5 | 17 | Citations (PDF) |
| 74 | Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer’s disease | 5.5 | 39 | Citations (PDF) |
| 75 | Initiation of Parkinson’s disease from gut to brain by δ-secretase | 12.4 | 99 | Citations (PDF) |
| 76 | Developing Insulin and BDNF Mimetics for Diabetes Therapy | 2.9 | 20 | Citations (PDF) |
| 77 | Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia | 12.5 | 50 | Citations (PDF) |
| 78 | The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease | 7.5 | 154 | Citations (PDF) |
| 79 | C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease | 13.7 | 130 | Citations (PDF) |
| 80 | BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease | 7.5 | 45 | Citations (PDF) |
| 81 | TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect | 3.4 | 14 | Citations (PDF) |
| 82 | TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone | 3.4 | 28 | Citations (PDF) |
| 83 | Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer’s disease | 7.5 | 30 | Citations (PDF) |
| 84 | BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle | 9.1 | 56 | Citations (PDF) |
| 85 | Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies | 9.3 | 34 | Citations (PDF) |
| 86 | Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities | 3.9 | 5 | Citations (PDF) |
| 87 | α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease | 7.3 | 93 | Citations (PDF) |
| 88 | CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment | 3.4 | 50 | Citations (PDF) |
| 89 | Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury | 3.7 | 14 | Citations (PDF) |
| 90 | δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer’s disease | 7.8 | 81 | Citations (PDF) |
| 91 | BDNF inhibits neurodegenerative disease–associated asparaginyl endopeptidase activity via phosphorylation by AKT | 5.4 | 49 | Citations (PDF) |
| 92 | α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation | 7.5 | 51 | Citations (PDF) |
| 93 | Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle | 4.2 | 32 | Citations (PDF) |
| 94 | Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease | 13.7 | 122 | Citations (PDF) |
| 95 | Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer’s Disease | 13.3 | 67 | Citations (PDF) |
| 96 | TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease | 7.5 | 121 | Citations (PDF) |
| 97 | MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life | 7.5 | 28 | Citations (PDF) |
| 98 | Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis | 5.6 | 39 | Citations (PDF) |
| 99 | Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease | 8.8 | 211 | Citations (PDF) |
| 100 | Sex differences in brain‐derived neurotrophic factor signaling and functions | 3.1 | 178 | Citations (PDF) |
| 101 | 7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents | 1.9 | 33 | Citations (PDF) |
| 102 | Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases | 3.7 | 56 | Citations (PDF) |
| 103 | Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins | 3.4 | 136 | Citations (PDF) |
| 104 | Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling | 7.5 | 179 | Citations (PDF) |
| 105 | 7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders | 12.5 | 180 | Citations (PDF) |
| 106 | Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist | 4.0 | 20 | Citations (PDF) |
| 107 | Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway | 4.5 | 33 | Citations (PDF) |
| 108 | Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability | 7.5 | 40 | Citations (PDF) |
| 109 | Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease | 13.7 | 277 | Citations (PDF) |
| 110 | Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome | 6.3 | 107 | Citations (PDF) |
| 111 | Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO | 7.5 | 39 | Citations (PDF) |
| 112 | Activation of Muscular TrkB by its Small Molecular Agonist 7,8-Dihydroxyflavone Sex-Dependently Regulates Energy Metabolism in Diet-Induced Obese Mice | 4.7 | 70 | Citations (PDF) |
| 113 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling | 16.3 | 283 | Citations (PDF) |
| 114 | NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury | 7.5 | 205 | Citations (PDF) |
| 115 | Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents | 4.3 | 66 | Citations (PDF) |
| 116 | Norepinephrine Protects against Amyloid-β Toxicity via TrkB | 2.6 | 58 | Citations (PDF) |
| 117 | Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats | 3.7 | 37 | Citations (PDF) |
| 118 | SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination | 7.5 | 227 | Citations (PDF) |
| 119 | Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease | 33.0 | 468 | Citations (PDF) |
| 120 | Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity | 4.2 | 48 | Citations (PDF) |
| 121 | Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor | 2.2 | 107 | Citations (PDF) |
| 122 | Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth | 13.3 | 138 | Citations (PDF) |
| 123 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage | 12.4 | 99 | Citations (PDF) |
| 124 | Proteinase 3–dependent caspase-3 cleavage modulates neutrophil death and inflammation | 10.6 | 143 | Citations (PDF) |
| 125 | Serine-arginine protein kinases: new players in neurodegenerative diseases? | 3.6 | 20 | Citations (PDF) |
| 126 | Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth | 7.1 | 40 | Citations (PDF) |
| 127 | Protection of Spiral Ganglion Neurons from Degeneration Using Small-Molecule TrkB Receptor Agonists | 3.7 | 47 | Citations (PDF) |
| 128 | Novel small molecule activators of the Trk family of receptor tyrosine kinases | 2.0 | 35 | Citations (PDF) |
| 129 | Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2 | 5.4 | 24 | Citations (PDF) |
| 130 | The roles of PIKE in tumorigenesis | 7.1 | 12 | Citations (PDF) |
| 131 | Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease | 2.9 | 124 | Citations (PDF) |
| 132 | Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate | 7.5 | 52 | Citations (PDF) |
| 133 | Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction | 2.5 | 24 | Citations (PDF) |
| 134 | Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves | 7.5 | 90 | Citations (PDF) |
| 135 | 7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease | 5.4 | 243 | Citations (PDF) |
| 136 | Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer? | 3.6 | 8 | Citations (PDF) |
| 137 | N
-acetyl serotonin derivatives as potent neuroprotectants for retinas | 7.5 | 47 | Citations (PDF) |
| 138 | Acridine Yellow G Blocks Glioblastoma Growth via Dual Inhibition of Epidermal Growth Factor Receptor and Protein Kinase C Kinases | 2.2 | 12 | Citations (PDF) |
| 139 | 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome | 2.8 | 108 | Citations (PDF) |
| 140 | Reactive Oxygen Species-Induced Actin Glutathionylation Controls Actin Dynamics in Neutrophils | 22.6 | 200 | Citations (PDF) |
| 141 | SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease | 3.7 | 64 | Citations (PDF) |
| 142 | Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth | 33.0 | 400 | Citations (PDF) |
| 143 | Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression | 5.6 | 56 | Citations (PDF) |
| 144 | Essential role of PIKE GTPases in neuronal protection against excitotoxic insults | 2.0 | 12 | Citations (PDF) |
| 145 | 7,8,3′-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo | 2.1 | 24 | Citations (PDF) |
| 146 | Asparaginyl endopeptidase cleaves TDP‐43 in brain | 3.1 | 62 | Citations (PDF) |
| 147 | N-Acetylserotonin | 4.3 | 65 | Citations (PDF) |
| 148 | PIKE‐mediated PI3‐kinase activity is required for AMPA receptor surface expression | 7.3 | 22 | Citations (PDF) |
| 149 | Loss of Tumor Suppressor Merlin in Advanced Breast Cancer Is due to Post-translational Regulation | 2.2 | 48 | Citations (PDF) |
| 150 | The association of phosphoinositide 3‐kinase enhancer A with hepatic insulin receptor enhances its kinase activity | 5.2 | 12 | Citations (PDF) |
| 151 | Identification of a Molecular Activator for Insulin Receptor with Potent Anti-diabetic Effects | 2.2 | 32 | Citations (PDF) |
| 152 | Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner | 2.5 | 38 | Citations (PDF) |
| 153 | Phosphoinositide 3-Kinase Enhancer Regulates Neuronal Dendritogenesis and Survival in Neocortex | 3.7 | 54 | Citations (PDF) |
| 154 | The N-terminal Fragment from Caspase-cleaved Serine/Arginine Protein-specific Kinase2 (SRPK2) Translocates into the Nucleus and Promotes Apoptosis | 2.2 | 15 | Citations (PDF) |
| 155 | N
-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice | 7.5 | 53 | Citations (PDF) |
| 156 | Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination | 7.5 | 67 | Citations (PDF) |
| 157 | Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning | 8.8 | 215 | Citations (PDF) |
| 158 | PIKE‐A is required for prolactin‐mediated STAT5a activation in mammary gland development | 7.3 | 31 | Citations (PDF) |
| 159 | Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice | 2.3 | 95 | Citations (PDF) |
| 160 | Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE) | 9.7 | 11 | Citations (PDF) |
| 161 | Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance | 4.2 | 24 | Citations (PDF) |
| 162 | Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome | 3.7 | 229 | Citations (PDF) |
| 163 | N
-acetylserotonin activates TrkB receptor in a circadian rhythm | 7.5 | 201 | Citations (PDF) |
| 164 | A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect | 5.6 | 200 | Citations (PDF) |
| 165 | A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone | 7.5 | 664 | Citations (PDF) |
| 166 | Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear | 7.5 | 193 | Citations (PDF) |
| 167 | Interaction of Akt-phosphorylated SRPK2 with 14-3-3 Mediates Cell Cycle and Cell Death in Neurons | 2.2 | 116 | Citations (PDF) |
| 168 | Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome | 7.5 | 76 | Citations (PDF) |
| 169 | Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity | 4.7 | 129 | Citations (PDF) |
| 170 | Nuclear translocation of active AKT is required for erythroid differentiation in erythropoietin treated K562 erythroleukemia cells | 2.6 | 23 | Citations (PDF) |
| 171 | Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumoniaBlood, 2009, 113, 4930-4941 | 4.8 | 52 | Citations (PDF) |
| 172 | Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B | 16.3 | 101 | Citations (PDF) |
| 173 | Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase | 13.3 | 135 | Citations (PDF) |
| 174 | Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion | 7.5 | 110 | Citations (PDF) |
| 175 | Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY | 7.5 | 114 | Citations (PDF) |
| 176 | Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival | 7.5 | 72 | Citations (PDF) |
| 177 | Nuclear phosphoinositide signaling | 5.8 | 34 | Citations (PDF) |
| 178 | Targeted deletion of tumor suppressor PTEN enhances neutrophil function and prevents neutropenia‐associated pneumonia | 0.6 | 0 | Citations (PDF) |
| 179 | Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control | 4.6 | 2,915 | Citations (PDF) |
| 180 | Ebp1 Association with Nucleophosmin/B23 Is Essential for Regulating Cell Proliferation and Suppressing Apoptosis | 2.2 | 52 | Citations (PDF) |
| 181 | Inhibition of Mammalian Target of Rapamycin Induces Phosphatidylinositol 3-Kinase-Dependent and Mnk-Mediated Eukaryotic Translation Initiation Factor 4E Phosphorylation | 2.5 | 145 | Citations (PDF) |
| 182 | Akt Phosphorylates MstI and Prevents Its Proteolytic Activation, Blocking FOXO3 Phosphorylation and Nuclear Translocation | 2.2 | 127 | Citations (PDF) |
| 183 | Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival | 7.5 | 90 | Citations (PDF) |
| 184 | Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death | 7.5 | 150 | Citations (PDF) |
| 185 | Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesisBlood, 2007, 109, 560-565 | 4.8 | 107 | Citations (PDF) |
| 186 | Overexpression of phospholipase C-γ1 inhibits NGF-induced neuronal differentiation by proliferative activity of SH3 domain | 2.6 | 2 | Citations (PDF) |
| 187 | Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation | 16.3 | 86 | Citations (PDF) |
| 188 | Protein kinase C-δ phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival | 3.8 | 14 | Citations (PDF) |
| 189 | Nuclear Functions of the Arf Guanine Nucleotide Exchange Factor BRAG2 | 2.3 | 25 | Citations (PDF) |
| 190 | PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell deathPIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death | 4.0 | 19 | Citations (PDF) |
| 191 | PIKE GTPase-mediated nuclear signalings promote cell survival | 2.4 | 9 | Citations (PDF) |
| 192 | Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells | 2.1 | 63 | Citations (PDF) |
| 193 | Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase | 7.3 | 115 | Citations (PDF) |
| 194 | Pike tyrosine phosphorylation regulates its apoptotic cleavage during programmed cell death | 3.5 | 6 | Citations (PDF) |
| 195 | Quantitative Analysis of Anti-apoptotic Function of Akt in Akt1 and Akt2 Double Knock-out Mouse Embryonic Fibroblast Cells under Normal and Stressed Conditions | 2.2 | 33 | Citations (PDF) |
| 196 | Interaction between ROCK II and Nucleophosmin/B23 in the Regulation of Centrosome Duplication | 2.5 | 93 | Citations (PDF) |
| 197 | Ebp1 isoforms distinctively regulate cell survival and differentiation | 7.5 | 116 | Citations (PDF) |
| 198 | Quantitative Analysis of Anti-apoptotic Function of Akt in Akt1 and Akt2 Double Knock-out Mouse Embryonic Fibroblast Cells under Normal and Stressed Conditions | 2.2 | 13 | Citations (PDF) |
| 199 | Nucleophosmin/B23, a multifunctional protein that can regulate apoptosis | 4.1 | 60 | Citations (PDF) |
| 200 | Src homology domains in phospholipase C-gamma1 mediate its anti-apoptotic action through regulating the enzymatic activity | 3.8 | 11 | Citations (PDF) |
| 201 | PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death | 3.0 | 38 | Citations (PDF) |
| 202 | PIKE GTPase Signaling and Function | 8.5 | 24 | Citations (PDF) |
| 203 | Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings | 7.5 | 39 | Citations (PDF) |
| 204 | Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation | 7.3 | 85 | Citations (PDF) |
| 205 | Nucleophosmin/B23, a Nuclear PI(3,4,5)P3 Receptor, Mediates the Antiapoptotic Actions of NGF by Inhibiting CAD | 13.3 | 122 | Citations (PDF) |
| 206 | PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt | 7.5 | 72 | Citations (PDF) |
| 207 | Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L | 7.5 | 148 | Citations (PDF) |
| 208 | PIKE (Phosphatidylinositol 3-Kinase Enhancer)-A GTPase Stimulates Akt Activity and Mediates Cellular Invasion | 2.2 | 82 | Citations (PDF) |
| 209 | PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus | 7.3 | 86 | Citations (PDF) |
| 210 | Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression | 6.5 | 119 | Citations (PDF) |
| 211 | PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis | 17.1 | 269 | Citations (PDF) |
| 212 | Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions | 33.6 | 197 | Citations (PDF) |
| 213 | Phospholipase Activity of Phospholipase C-γ1 Is Required for Nerve Growth Factor-regulated MAP Kinase Signaling Cascade in PC12 Cells | 2.2 | 23 | Citations (PDF) |
| 214 | Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo | 2.2 | 330 | Citations (PDF) |
| 215 | Paclitaxel-resistant Human Ovarian Cancer Cells Undergo c-Jun NH2-terminal Kinase-mediated Apoptosis in Response to Noscapine | 2.2 | 127 | Citations (PDF) |
| 216 | Inositol Pyrophosphates Are Required for DNA Hyperrecombination in Protein Kinase C1 Mutant Yeast† | 2.4 | 80 | Citations (PDF) |
| 217 | Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE | 37.9 | 152 | Citations (PDF) |
| 218 | GRAB: A Physiologic Guanine Nucleotide Exchange Factor for Rab3a, which Interacts with Inositol Hexakisphosphate Kinase | 11.0 | 99 | Citations (PDF) |
| 219 | Sustained Activation of p34 Is Required for Noscapine-induced Apoptosis | 2.2 | 37 | Citations (PDF) |
| 220 | FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle | 7.5 | 143 | Citations (PDF) |
| 221 | Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses | 4.6 | 128 | Citations (PDF) |
| 222 | Dexras1 | 11.0 | 314 | Citations (PDF) |
| 223 | PIKE | 33.6 | 152 | Citations (PDF) |
| 224 | Protein 4.1N Binding to Nuclear Mitotic Apparatus Protein in PC12 Cells Mediates the Antiproliferative Actions of Nerve Growth Factor | 3.7 | 65 | Citations (PDF) |
| 225 | Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells | 7.5 | 339 | Citations (PDF) |
| 226 | Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction | 0.7 | 17 | Citations (PDF) |
| 227 | 7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis | 0.7 | 66 | Citations (PDF) |
| 228 | C/EBPβ dictates postmenopausal FSHβ transcription and blockade of AEP/C/EBPβ pathway alleviates osteoporosis | 13.9 | 0 | Citations (PDF) |
