| 1 | TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model | 12.5 | 49 | Citations (PDF) |
| 2 | Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies | 36.3 | 245 | Citations (PDF) |
| 3 | Phenotypic Differences between the Alzheimer’s Disease-Related hAPP-J20 Model and HeterozygousZbtb20Knock-Out MiceENeuro, 2021, 8, ENEURO.0089-21.2021 | 2.1 | 13 | Citations (PDF) |
| 4 | Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity | 17.6 | 262 | Citations (PDF) |
| 5 | Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models | 3.5 | 21 | Citations (PDF) |
| 6 | A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease | 12.5 | 169 | Citations (PDF) |
| 7 | Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1 | 14.1 | 65 | Citations (PDF) |
| 8 | Tau Reduction Prevents Key Features of Autism in Mouse ModelsNeuron, 2020, 106, 421-437.e11 | 11.0 | 89 | Citations (PDF) |
| 9 | Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease | 5.0 | 213 | Citations (PDF) |
| 10 | Interaction Between Fibrinogen and the Microglial CD11b Receptor Mediates Several Neuropathological Alterations in a Mouse Model of Alzheimer's Disease | 0.6 | 0 | Citations (PDF) |
| 11 | Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer’s Disease | 11.0 | 241 | Citations (PDF) |
| 12 | Istradefylline reduces memory deficits in aging mice with amyloid pathology | 5.1 | 91 | Citations (PDF) |
| 13 | Klotho controls the brain–immune system interface in the choroid plexus | 7.5 | 141 | Citations (PDF) |
| 14 | Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration | 23.5 | 211 | Citations (PDF) |
| 15 | Neuronal levels and sequence of tau modulate the power of brain rhythms | 5.1 | 38 | Citations (PDF) |
| 16 | The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease | 0.9 | 20 | Citations (PDF) |
| 17 | Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture | 14.1 | 88 | Citations (PDF) |
| 18 | The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease | 0.9 | 25 | Citations (PDF) |
| 19 | Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity | 2.2 | 33 | Citations (PDF) |
| 20 | Incidence and impact of subclinical epileptiform activity in Alzheimer's disease | 6.6 | 539 | Citations (PDF) |
| 21 | Network abnormalities and interneuron dysfunction in Alzheimer disease | 20.8 | 984 | Citations (PDF) |
| 22 | Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice | 5.2 | 127 | Citations (PDF) |
| 23 | Network dysfunction inα‐synuclein transgenic mice and human Lewy body dementia | 3.7 | 62 | Citations (PDF) |
| 24 | Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice | 3.7 | 197 | Citations (PDF) |
| 25 | Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory | 17.1 | 271 | Citations (PDF) |
| 26 | Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice | 17.1 | 448 | Citations (PDF) |
| 27 | Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β | 5.4 | 157 | Citations (PDF) |
| 28 | DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice | 13.7 | 191 | Citations (PDF) |
| 29 | Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models | 33.0 | 235 | Citations (PDF) |
| 30 | Tau reduction prevents disease in a mouse model of Dravet syndrome | 6.6 | 137 | Citations (PDF) |
| 31 | Life Extension Factor Klotho Enhances Cognition | 6.3 | 319 | Citations (PDF) |
| 32 | Tau Reduction Diminishes Spatial Learning and Memory Deficits after Mild Repetitive Traumatic Brain Injury in Mice | 2.3 | 95 | Citations (PDF) |
| 33 | Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease | 17.6 | 714 | Citations (PDF) |
| 34 | Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice | 3.4 | 116 | Citations (PDF) |
| 35 | Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β | 17.1 | 491 | Citations (PDF) |
| 36 | Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction | 6.6 | 971 | Citations (PDF) |
| 37 | Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model | 7.5 | 629 | Citations (PDF) |
| 38 | Alzheimer Mechanisms and Therapeutic StrategiesCell, 2012, 148, 1204-1222 | 33.6 | 1,717 | Citations (PDF) |
| 39 | Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model | 33.6 | 1,225 | Citations (PDF) |
| 40 | Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits | 2.3 | 122 | Citations (PDF) |
| 41 | Selective targeting of microglia by quantum dots | 9.0 | 75 | Citations (PDF) |
| 42 | The Many Faces of Tau | 11.0 | 823 | Citations (PDF) |
| 43 | Tau Reduction Does Not Prevent Motor Deficits in Two Mouse Models of Parkinson's Disease | 2.3 | 52 | Citations (PDF) |
| 44 | Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease | 3.7 | 634 | Citations (PDF) |
| 45 | Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks | 17.1 | 1,619 | Citations (PDF) |
| 46 | Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein | 3.7 | 142 | Citations (PDF) |
| 47 | Phospholipase A2 and arachidonic acid in Alzheimer's disease | 2.4 | 141 | Citations (PDF) |
| 48 | Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network | 11.0 | 296 | Citations (PDF) |
| 49 | Cellular Source of Apolipoprotein E4 Determines Neuronal Susceptibility to Excitotoxic Injury in Transgenic Mice | 3.4 | 77 | Citations (PDF) |
| 50 | Reversing EphB2 depletion rescues cognitive functions in Alzheimer model | 37.9 | 414 | Citations (PDF) |
| 51 | Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic Aβ Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice | 3.7 | 149 | Citations (PDF) |
| 52 | Epilepsy and Cognitive Impairments in Alzheimer Disease | 6.8 | 657 | Citations (PDF) |
| 53 | Collagen VI protects neurons against Aβ toxicity | 17.1 | 149 | Citations (PDF) |
| 54 | Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease | 16.4 | 199 | Citations (PDF) |
| 55 | プリオンコネクション | 0.0 | 0 | Citations (PDF) |
| 56 | Synaptic Depression and Aberrant Excitatory Network Activity in Alzheimer’s Disease: Two Faces of the Same Coin? | 3.6 | 157 | Citations (PDF) |
| 57 | Abnormal social behaviors in mice lacking Fgf17 | 2.3 | 110 | Citations (PDF) |
| 58 | Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease | 17.1 | 353 | Citations (PDF) |
| 59 | Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice | 3.4 | 49 | Citations (PDF) |
| 60 | Paths of Convergence: Sirtuins in Aging and Neurodegeneration | 11.0 | 171 | Citations (PDF) |
| 61 | Enkephalin Elevations Contribute to Neuronal and Behavioral Impairments in a Transgenic Mouse Model of Alzheimer's Disease | 3.7 | 78 | Citations (PDF) |
| 62 | Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models* | 2.2 | 397 | Citations (PDF) |
| 63 | Spatial cognition and the human navigation network in AD and MCI | 1.0 | 230 | Citations (PDF) |
| 64 | Reelin Depletion in the Entorhinal Cortex of Human Amyloid Precursor Protein Transgenic Mice and Humans with Alzheimer's Disease | 3.7 | 181 | Citations (PDF) |
| 65 | Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease | 11.0 | 1,630 | Citations (PDF) |
| 66 | 100 Years and Counting: Prospects for Defeating Alzheimer's Disease | 36.3 | 530 | Citations (PDF) |
| 67 | Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease | 11.0 | 427 | Citations (PDF) |
| 68 | Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology | 10.6 | 350 | Citations (PDF) |
| 69 | A network dysfunction perspective on neurodegenerative diseases | 37.9 | 645 | Citations (PDF) |
| 70 | Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-Like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice | 3.7 | 239 | Citations (PDF) |
| 71 | SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling | 2.2 | 725 | Citations (PDF) |
| 72 | Vulnerability of Dentate Granule Cells to Disruption of Arc Expression in Human Amyloid Precursor Protein Transgenic Mice | 3.7 | 146 | Citations (PDF) |
| 73 | High β-Secretase Activity Elicits Neurodegeneration in Transgenic Mice Despite Reductions in Amyloid-β Levels | 2.2 | 93 | Citations (PDF) |
| 74 | Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease | 3.7 | 328 | Citations (PDF) |
| 75 | Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice | 3.7 | 387 | Citations (PDF) |
| 76 | Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice | 3.7 | 159 | Citations (PDF) |
| 77 | Intracellularly generated amyloid-β peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells | 3.8 | 30 | Citations (PDF) |
| 78 | Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation | 33.0 | 130 | Citations (PDF) |
| 79 | Apolipoprotein E: Diversity of Cellular Origins, Structural and Biophysical Properties, and Effects in Alzheimer's Disease | 2.4 | 215 | Citations (PDF) |
| 80 | Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice | 7.5 | 325 | Citations (PDF) |
| 81 | Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits | 7.5 | 389 | Citations (PDF) |
| 82 | Inflammation in Neurodegenerative Disease—A Double-Edged Sword | 11.0 | 1,194 | Citations (PDF) |
| 83 | Androgens Protect against Apolipoprotein E4-Induced Cognitive Deficits | 3.7 | 182 | Citations (PDF) |
| 84 | Modulation of Alzheimer-Like Synaptic and Cholinergic Deficits in Transgenic Mice by Human Apolipoprotein E Depends on Isoform , Aging, and Overexpression of Amyloid β Peptides But Not on Plaque Formation | 3.7 | 179 | Citations (PDF) |
| 85 | TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice | 33.0 | 612 | Citations (PDF) |
| 86 | β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease | 7.5 | 583 | Citations (PDF) |
| 87 | Apolipoprotein E and cognitive performance | 37.9 | 232 | Citations (PDF) |
| 88 | Alzheimer's Disease-like Cerebrovascular Pathology in Transforming Growth Factor-beta1 Transgenic Mice and Functional Metabolic Correlates | 4.0 | 73 | Citations (PDF) |
| 89 | Hypothalamic–Pituitary–Adrenal Dysfunction inApoe−/−Mice: Possible Role in Behavioral and Metabolic Alterations | 3.7 | 126 | Citations (PDF) |
| 90 | High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation | 3.7 | 1,883 | Citations (PDF) |
| 91 | Chronic Overproduction of Transforming Growth Factor-β1 by Astrocytes Promotes Alzheimer's Disease-Like Microvascular Degeneration in Transgenic Mice | 3.4 | 236 | Citations (PDF) |
| 92 | Astroglial Expression of Human α1-Antichymotrypsin Enhances Alzheimer-like Pathology in Amyloid Protein Precursor Transgenic Mice | 3.4 | 137 | Citations (PDF) |
| 93 | Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease | 2.3 | 97 | Citations (PDF) |
| 94 | Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe−/−Mice: Isoform-Specific Effects on Neurodegeneration | 3.7 | 344 | Citations (PDF) |
| 95 | Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis | 7.5 | 86 | Citations (PDF) |
| 96 | Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120 | 3.5 | 76 | Citations (PDF) |
| 97 | Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice1Published on the World Wide Web on 7 June 1999.1 | 2.5 | 50 | Citations (PDF) |
| 98 | Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models | 7.5 | 1,108 | Citations (PDF) |
| 99 | Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice | 11.0 | 1,032 | Citations (PDF) |
| 100 | Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors | 3.4 | 67 | Citations (PDF) |
| 101 | Novel role of human CD4 molecule identified in neurodegeneration | 33.0 | 27 | Citations (PDF) |
| 102 | Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus | 2.3 | 69 | Citations (PDF) |
| 103 | Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice | 33.6 | 563 | Citations (PDF) |
| 104 | Amyloid Protein Precursor Stimulates Excitatory Amino Acid Transport | 2.2 | 50 | Citations (PDF) |
| 105 | Isoform-specific effects of human apolipoprotein E on brain function revealed in
ApoE
knockout mice: Increased susceptibility of females | 7.5 | 358 | Citations (PDF) |
| 106 | Corticotropin-releasing Factor and Adrenocorticotrophic Hormone as Potential Central Mediators of OB Effects | 2.2 | 81 | Citations (PDF) |
| 107 | Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease | 6.0 | 250 | Citations (PDF) |
| 108 | Astroglial overproduction of TGF-β1 enhances inflammatory central nervous system disease in transgenic mice | 2.3 | 149 | Citations (PDF) |
| 109 | Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo | 2.3 | 113 | Citations (PDF) |
| 110 | Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli | 7.5 | 108 | Citations (PDF) |
| 111 | Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease | 37.9 | 427 | Citations (PDF) |
| 112 | Neurotrophic and Neuroprotective Effects of hAPP in Transgenic Micea | 4.0 | 83 | Citations (PDF) |
| 113 | Spatial learning deficit in mice expressing human 751-amino acid β-amyloid precursor protein | 1.5 | 60 | Citations (PDF) |
| 114 | Central Nervous System Expression of HIV-1 Gp120 Activates the Hypothalamic-Pituitary-Adrenal Axis: Evidence for Involvement of NMDA Receptors and Nitric Oxide Synthase | 2.3 | 56 | Citations (PDF) |
| 115 | Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine | 2.5 | 141 | Citations (PDF) |
| 116 | Neurite Outgrowth on Non-permissive SubstratesIn Vitrois Enhanced by Ectopic Expression of the Neural Adhesion Molecule L1 by Mouse Astrocytes | 3.5 | 40 | Citations (PDF) |
| 117 | β-Secretase Processing of the β-Amyloid Precursor Protein in Transgenic Mice Is Efficient in Neurons but Inefficient in Astrocytes | 2.2 | 94 | Citations (PDF) |
| 118 | Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. | 10.6 | 51 | Citations (PDF) |
| 119 | Pathogenesis of HIV-1 Associated Neurodegeneration | 1.0 | 111 | Citations (PDF) |
| 120 | Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: In vivo comparison of distinct GFAP-lacZ transgenes | 5.0 | 77 | Citations (PDF) |
| 121 | Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein | 37.9 | 2,564 | Citations (PDF) |
| 122 | Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo. | 9.3 | 118 | Citations (PDF) |
| 123 | Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein. | 9.3 | 88 | Citations (PDF) |
| 124 | Levels and Alternative Splicing of Amyloid β Protein Precursor (APP) Transcripts in Brains of APP Transgenic Mice and Humans with Alzheimer's Disease | 2.2 | 242 | Citations (PDF) |
| 125 | Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent | 11.0 | 154 | Citations (PDF) |
| 126 | Immunization-induced inflammatory infiltration of the central nervous system in transgenic mice expressing a microbial antigen in astrocytes | 2.3 | 15 | Citations (PDF) |
| 127 | Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice | 2.5 | 275 | Citations (PDF) |
| 128 | Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice | 37.9 | 711 | Citations (PDF) |
| 129 | A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes | 2.3 | 10 | Citations (PDF) |
| 130 | Expression of cathepsin G-like and α1-antichymotrypsin-like proteins in reactive astrocytes | 2.5 | 38 | Citations (PDF) |
| 131 | Molecular profile of reactive astrocytes—Implications for their role in neurologic disease | 2.3 | 1,399 | Citations (PDF) |
| 132 | Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. | 7.5 | 991 | Citations (PDF) |
| 133 | Purification and Cloning of Brain Proteases Capable of Degrading the ?-Amyloid Precursor Protein | 4.0 | 13 | Citations (PDF) |
| 134 | The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV) | 2.3 | 47 | Citations (PDF) |
| 135 | Prolonged survival and partial recovery in AIDS‐associated progressive multifocal leukoencephalopathy | 1.0 | 109 | Citations (PDF) |
| 136 | Clinical Management of Neuropathic Pain | 2.6 | 8 | Citations (PDF) |
| 137 | Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit | 0.7 | 36 | Citations (PDF) |
