| 1 | Identification and characterization of human GDF15 knockouts | 17.1 | 16 | Citations (PDF) |
| 2 | South Asian medical cohorts reveal strong founder effects and high rates of homozygosity | 13.7 | 40 | Citations (PDF) |
| 3 | Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification | 8.3 | 17 | Citations (PDF) |
| 4 | Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index | 3.2 | 3 | Citations (PDF) |
| 5 | Identification of genetic effects underlying type 2 diabetes in South Asian and European populations | 4.4 | 60 | Citations (PDF) |
| 6 | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | 25.2 | 675 | Citations (PDF) |
| 7 | A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation | 25.2 | 190 | Citations (PDF) |
| 8 | Stroke genetics informs drug discovery and risk prediction across ancestries | 37.9 | 561 | Citations (PDF) |
| 9 | Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis | 10.6 | 47 | Citations (PDF) |
| 10 | Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes | 13.7 | 116 | Citations (PDF) |
| 11 | Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes | 13.7 | 103 | Citations (PDF) |
| 12 | Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci | 7.1 | 58 | Citations (PDF) |
| 13 | Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis | 18.0 | 424 | Citations (PDF) |
| 14 | Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals | 25.2 | 177 | Citations (PDF) |
| 15 | Heterozygous
ABCG5
Gene Deficiency and Risk of Coronary Artery Disease | 2.9 | 68 | Citations (PDF) |
| 16 | Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program | 2.3 | 25 | Citations (PDF) |
| 17 | Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus | 2.9 | 10 | Citations (PDF) |
| 18 | Evaluating drug targets through human loss-of-function genetic variation | 37.9 | 183 | Citations (PDF) |
| 19 | The mutational constraint spectrum quantified from variation in 141,456 humans | 37.9 | 9,351 | Citations (PDF) |
| 20 | The effect of LRRK2 loss-of-function variants in humans | 33.0 | 112 | Citations (PDF) |
| 21 | Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis | 25.2 | 727 | Citations (PDF) |
| 22 | A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease | 3.2 | 159 | Citations (PDF) |
| 23 | The promise and reality of therapeutic discovery from large cohorts | 10.6 | 14 | Citations (PDF) |
| 24 | Genome-wide association study of peripheral artery disease in the Million Veteran Program | 33.0 | 296 | Citations (PDF) |
| 25 | Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls | 37.9 | 310 | Citations (PDF) |
| 26 | Rare Protein-Truncating Variants in
APOB
, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease | 2.9 | 69 | Citations (PDF) |
| 27 | CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease | 18.0 | 90 | Citations (PDF) |
| 28 | Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution | 25.2 | 108 | Citations (PDF) |
| 29 | DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes | 4.2 | 48 | Citations (PDF) |
| 30 | Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci | 7.8 | 110 | Citations (PDF) |
| 31 | Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease | 13.7 | 96 | Citations (PDF) |
| 32 | Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes | 25.2 | 438 | Citations (PDF) |
| 33 | Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling | 18.0 | 111 | Citations (PDF) |
| 34 | FP526VASCULAR CXCR4 LIMITS ATHEROSCLEROSIS BY MAINTAINING ARTERIAL INTEGRITY | 0.8 | 1 | Citations (PDF) |
| 35 | Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program | 25.2 | 625 | Citations (PDF) |
| 36 | Association ofLPAVariants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies | 11.1 | 633 | Citations (PDF) |
| 37 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | 25.2 | 1,600 | Citations (PDF) |
| 38 | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk | 25.2 | 580 | Citations (PDF) |
| 39 | Rare and low-frequency coding variants alter human adult height | 37.9 | 622 | Citations (PDF) |
| 40 | Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease | 16.5 | 192 | Citations (PDF) |
| 41 | Common coding variant in
SERPINA1
increases the risk for large artery stroke | 7.5 | 50 | Citations (PDF) |
| 42 | Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease | 2.3 | 248 | Citations (PDF) |
| 43 | Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis | 21.7 | 213 | Citations (PDF) |
| 44 | Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity | 37.9 | 353 | Citations (PDF) |
| 45 | Loss of Cardioprotective Effects at the
ADAMTS7
Locus as a Result of Gene-Smoking Interactions | 18.0 | 62 | Citations (PDF) |
| 46 | Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms | 25.2 | 317 | Citations (PDF) |
| 47 | ANGPTL3 Deficiency and Protection Against Coronary Artery Disease | 2.3 | 449 | Citations (PDF) |
| 48 | Genetic variation at 16q24.2 is associated with small vessel stroke | 6.6 | 85 | Citations (PDF) |
| 49 | Exome-wide association study of plasma lipids in >300,000 individuals | 25.2 | 552 | Citations (PDF) |
| 50 | New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals | 3.8 | 52 | Citations (PDF) |
| 51 | Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease | 6.0 | 64 | Citations (PDF) |
| 52 | Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study | 4.2 | 67 | Citations (PDF) |
| 53 | Sequence data and association statistics from 12,940 type 2 diabetes cases and controls | 5.7 | 36 | Citations (PDF) |
| 54 | Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis | 8.0 | 411 | Citations (PDF) |
| 55 | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease | 25.2 | 257 | Citations (PDF) |
| 56 | Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity | 25.2 | 397 | Citations (PDF) |
| 57 | The genetic architecture of type 2 diabetes | 37.9 | 1,067 | Citations (PDF) |
| 58 | Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels | 2.3 | 236 | Citations (PDF) |
| 59 | Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia | 2.3 | 886 | Citations (PDF) |
| 60 | Common and Rare Genetic Variation in
CCR2
,
CCR5
, or
CX3CR1
and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits | 3.8 | 24 | Citations (PDF) |
| 61 | Coding Variation in
ANGPTL4,
LPL,
and
SVEP1
and the Risk of Coronary Disease | 34.5 | 491 | Citations (PDF) |
| 62 | Low-frequency and common genetic variation in ischemic stroke | 1.0 | 161 | Citations (PDF) |
| 63 | Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents | 25.2 | 126 | Citations (PDF) |
| 64 | Analysis of protein-coding genetic variation in 60,706 humans | 37.9 | 9,981 | Citations (PDF) |
| 65 | Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension | 25.2 | 302 | Citations (PDF) |
| 66 | The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals | 25.2 | 416 | Citations (PDF) |
| 67 | A genomic approach to therapeutic target validation identifies a glucose-lowering
GLP1R
variant protective for coronary heart disease | 12.5 | 113 | Citations (PDF) |
| 68 | Using Mendelian Randomization Studies to Assess Causality and Identify New Therapeutic Targets in Cardiovascular Medicine | 1.4 | 5 | Citations (PDF) |
| 69 | Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes | 13.7 | 171 | Citations (PDF) |
| 70 | Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study | 17.9 | 244 | Citations (PDF) |
| 71 | Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease | 36.3 | 519 | Citations (PDF) |
| 72 | Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study | 2.3 | 167 | Citations (PDF) |
| 73 | From Loci to Biology | 13.1 | 58 | Citations (PDF) |
| 74 | Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms | 2.9 | 21 | Citations (PDF) |
| 75 | Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study | 1.8 | 33 | Citations (PDF) |
| 76 | Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial | 62.1 | 224 | Citations (PDF) |
| 77 | Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study | 21.7 | 441 | Citations (PDF) |
| 78 | New genetic loci link adipose and insulin biology to body fat distribution | 37.9 | 1,589 | Citations (PDF) |
| 79 | Genetic studies of body mass index yield new insights for obesity biology | 37.9 | 4,533 | Citations (PDF) |
| 80 | Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study | 21.7 | 457 | Citations (PDF) |
| 81 | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation | 25.2 | 342 | Citations (PDF) |
| 82 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | 25.2 | 2,524 | Citations (PDF) |
| 83 | Abstract 14351: Increased Levels of IgM Autoantibodies to Oxidation-Specific Epitopes are Inversely Associated With Coronary Heart Disease: Analyses of Data From 204,257 Participants | 18.0 | 2 | Citations (PDF) |
| 84 | A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach | 3.2 | 87 | Citations (PDF) |
| 85 | Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease | 34.5 | 412 | Citations (PDF) |
| 86 | Epidemiology and Public Health Policy of Tobacco Use and Cardiovascular Disorders in Low- and Middle-Income Countries | 6.0 | 25 | Citations (PDF) |
| 87 | Defining the role of common variation in the genomic and biological architecture of adult human height | 25.2 | 1,982 | Citations (PDF) |
| 88 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | 25.2 | 1,037 | Citations (PDF) |
| 89 | Frequency and Determinants of Intracranial Atherosclerotic Stroke in Urban Pakistan | 1.6 | 7 | Citations (PDF) |
| 90 | Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction | 37.9 | 635 | Citations (PDF) |
| 91 | Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption | 7.8 | 271 | Citations (PDF) |
| 92 | Discovery and refinement of loci associated with lipid levels | 25.2 | 3,040 | Citations (PDF) |
| 93 | Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India | 4.2 | 182 | Citations (PDF) |
| 94 | Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes | 25.2 | 1,878 | Citations (PDF) |
| 95 | Large-scale association analysis identifies new risk loci for coronary artery disease | 25.2 | 1,573 | Citations (PDF) |
| 96 | Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci | 25.2 | 514 | Citations (PDF) |
| 97 | Apolipoprotein(a) Isoforms and the Risk of Vascular Disease | 2.3 | 322 | Citations (PDF) |
| 98 | B-Type Natriuretic Peptides and Cardiovascular Risk | 18.0 | 359 | Citations (PDF) |
| 99 | The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia | 5.3 | 97 | Citations (PDF) |
| 100 | Complete loss of SLC30A8 in humans improves glucose metabolism and beta cell function | 7.5 | 7 | Citations (PDF) |
