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280 PR articles • 49,779 PR citations • Sorted by year • Download PDF (PDF by citations)
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1Coding, or non-coding, that is the question
Cell Research, 2024, 34, 609-629
12.555Citations (PDF)
2The HECT family of E3 ubiquitin ligases and PTEN
Seminars in Cancer Biology, 2022, 85, 43-51
14.124Citations (PDF)
3Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids
Cells, 2022, 11, 1235
4.829Citations (PDF)
4Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia
Nature Methods, 2021, 18, 293-302
25.99Citations (PDF)
5Inhibition of HECT E3 ligases as potential therapy for COVID-19
Cell Death and Disease, 2021, 12,
8.749Citations (PDF)
6Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner
Advanced Science, 2021, 8,
12.7148Citations (PDF)
7Peptide Platform as a Powerful Tool in the Fight against COVID-19
Viruses, 2021, 13, 1667
3.313Citations (PDF)
8Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations
Journal of Molecular Biology, 2021, 433, 167177
4.240Citations (PDF)
9Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs
Genome Biology, 2021, 22,
8.2133Citations (PDF)
10Genetic fusions favor tumorigenesis through degron loss in oncogenes
Nature Communications, 2021, 12,
13.930Citations (PDF)
11WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models
Journal of Clinical Investigation, 2021, 131,
10.723Citations (PDF)
12PTEN Mouse Models of Cancer Initiation and Progression
Cold Spring Harbor Perspectives in Medicine, 2020, 10, a037283
6.727Citations (PDF)
13The Tug1 lncRNA locus is essential for male fertility
Genome Biology, 2020, 21,
8.299Citations (PDF)
14Development of the Proximal-Anterior Skeletal Elements in the Mouse Hindlimb Is Regulated by a Transcriptional and Signaling Network Controlled by <i>Sall4</i>
Genetics, 2020, 215, 129-141
4.213Citations (PDF)
15WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition
New England Journal of Medicine, 2020, 382, 2103-2116
43.769Citations (PDF)
16PTENP1 is a ceRNA for PTEN: it’s CRISPR clear
Journal of Hematology and Oncology, 2020, 13,
30.919Citations (PDF)
17LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
Nature Cell Biology, 2020, 22, 246-256
16.986Citations (PDF)
18Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle
Cell Research, 2020, 31, 80-93
12.586Citations (PDF)
19Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
Nature Communications, 2019, 10,
13.924Citations (PDF)
20Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
Acta Neuropathologica, 2019, 138, 1053-1074
9.3164Citations (PDF)
21The Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy
Frontiers in Oncology, 2019, 9,
2.737Citations (PDF)
22Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling
Cell Communication and Signaling, 2019, 17,
8.160Citations (PDF)
23AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions
Nature Cell Biology, 2019, 21, 226-237
16.9145Citations (PDF)
24Intragenic antagonistic roles of protein and circRNA in tumorigenesis
Cell Research, 2019, 29, 628-640
12.5151Citations (PDF)
25PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage
Cancer Discovery, 2019, 9, 1306-1323
25.674Citations (PDF)
26Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Science, 2019, 364,
36.4259Citations (PDF)
27The PTEN–PI3K Axis in Cancer
Biomolecules, 2019, 9, 153
4.4244Citations (PDF)
28Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy
Cell Research, 2019, 29, 446-459
12.536Citations (PDF)
29miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells
Journal of Experimental and Clinical Cancer Research, 2019, 38,
11.578Citations (PDF)
30PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
Nature Communications, 2019, 10,
13.967Citations (PDF)
31Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita
Nature Genetics, 2019, 51, 1518-1529
26.1126Citations (PDF)
32SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression
Developmental Cell, 2019, 48, 329-344.e5
7.865Citations (PDF)
33Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
Journal of Clinical Investigation, 2019, 129, 215-222
10.727Citations (PDF)
34An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance
Cell, 2018, 173, 649-664.e20
34.1283Citations (PDF)
35Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
Nature Communications, 2018, 9,
13.947Citations (PDF)
36An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
Nature Genetics, 2018, 50, 206-218
26.1280Citations (PDF)
37Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms
Nature Medicine, 2018, 24, 165-175
39.5169Citations (PDF)
38A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
Nature Communications, 2018, 9,
13.926Citations (PDF)
39The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth
Science Signaling, 2018, 11,
5.510Citations (PDF)
40ZBTB7A governs estrogen receptor alpha expression in breast cancer
Journal of Molecular Cell Biology, 2018, 10, 273-284
3.619Citations (PDF)
41Preclinical and Coclinical Studies in Prostate Cancer
Cold Spring Harbor Perspectives in Medicine, 2018, 8, a030544
6.76Citations (PDF)
42Loss of <i>LDAH</i> associated with prostate cancer and hearing loss
Human Molecular Genetics, 2018, 27, 4194-4203
3.018Citations (PDF)
43The functions and regulation of the PTEN tumour suppressor: new modes and prospects
Nature Reviews Molecular Cell Biology, 2018, 19, 547-562
78.9791Citations (PDF)
44Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival
Theranostics, 2018, 8, 4359-4371
11.535Citations (PDF)
45Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity
Cancer Discovery, 2017, 7, 750-765
25.6135Citations (PDF)
46MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia
Blood, 2017, 129, 1791-1801
4.2168Citations (PDF)
47The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
Cancer Discovery, 2017, 7, 424-441
25.670Citations (PDF)
48Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes <i>PTEN/TP53-</i>Deficient Prostate Cancer to Radiation
Molecular Cancer Therapeutics, 2017, 16, 1279-1289
1.853Citations (PDF)
49Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling
Cancer Research, 2017, 77, 3685-3699
0.633Citations (PDF)
50The Epitranscriptome of Noncoding RNAs in Cancer
Cancer Discovery, 2017, 7, 359-368
25.6147Citations (PDF)
51Regulation of NF-κB by PML and PML-RARα
Scientific Reports, 2017, 7,
3.520Citations (PDF)
52Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach
Scientific Reports, 2017, 7,
3.519Citations (PDF)
53Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure
Cancer Cell, 2017, 32, 552-560
38.5275Citations (PDF)
54<i>MCM7</i>and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer
Carcinogenesis, 2017, 38, 64-75
2.960Citations (PDF)
55The RNA-binding protein ESRP1 promotes human colorectal cancer progression
Oncotarget, 2017, 8, 10007-10024
1.764Citations (PDF)
56Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome <i>TP53</i> mutated/deleted clones
Oncotarget, 2017, 8, 35508-35522
1.776Citations (PDF)
57Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice
Thrombosis and Haemostasis, 2016, 115, 969-978
4.212Citations (PDF)
58The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors
Cell Reports, 2016, 17, 2776-2788
6.449Citations (PDF)
59Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations
Cell, 2016, 165, 289-302
34.1659Citations (PDF)
60Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma
Molecular Cell, 2016, 62, 34-46
13.485Citations (PDF)
61Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells
Journal of Immunology, 2016, 196, 4110-4121
0.617Citations (PDF)
62PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development
Cell Reports, 2016, 16, 2415-2427
6.4150Citations (PDF)
63PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
Molecular Cell, 2016, 63, 1006-1020
13.4142Citations (PDF)
64The pleiotropic role of non-coding genes in development and cancer
Current Opinion in Cell Biology, 2016, 43, 104-113
3.922Citations (PDF)
65PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity
Oncotarget, 2016, 7, 66386-66397
1.721Citations (PDF)
66Endosome and INPP4B
Oncotarget, 2016, 7, 5-6
1.718Citations (PDF)
67Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth
Oncotarget, 2016, 7, 23919-23932
1.755Citations (PDF)
68LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair
Nature Communications, 2015, 6,
13.921Citations (PDF)
69The Promyelocytic Leukemia Protein Is Upregulated in Conditions of Obesity and Liver Steatosis
International Journal of Biological Sciences, 2015, 11, 629-632
8.812Citations (PDF)
70Pseudogenes in Human Cancer
Frontiers in Medicine, 2015, 2,
2.6103Citations (PDF)
71Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling
Oncotarget, 2015, 6, 1435-1445
1.792Citations (PDF)
72ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM
Molecular Cancer Research, 2015, 13, 1206-1217
3.246Citations (PDF)
73<i>In Vivo</i> Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K–AKT Signaling at Endosomes
Cancer Discovery, 2015, 5, 740-751
25.697Citations (PDF)
74Suppression of <i>CHK1</i> by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis
Cancer Discovery, 2015, 5, 550-563
25.626Citations (PDF)
75PTEN ceRNA networks in human cancer
Methods, 2015, 77-78, 41-50
3.6128Citations (PDF)
76p53 at the endoplasmic reticulum regulates apoptosis in a Ca <sup>2+</sup> -dependent manner
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112, 1779-1784
7.6290Citations (PDF)
77PTEN Is a Negative Regulator of NK Cell Cytolytic Function
Journal of Immunology, 2015, 194, 1832-1840
0.642Citations (PDF)
78Distinct germline progenitor subsets defined through Tsc2– <scp>mTORC</scp> 1 signaling
EMBO Reports, 2015, 16, 467-480
5.264Citations (PDF)
79A Genetic Platform to Model Sarcomagenesis from Primary Adult Mesenchymal Stem Cells
Cancer Discovery, 2015, 5, 396-409
25.628Citations (PDF)
80Mouse hospital and co-clinical trial project—from bench to bedside
Nature Reviews Clinical Oncology, 2015, 12, 491-498
75.5122Citations (PDF)
81Morgana acts as an oncosuppressor in chronic myeloid leukemia
Blood, 2015, 125, 2245-2253
4.221Citations (PDF)
82The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo
Cell, 2015, 161, 319-332
34.1318Citations (PDF)
83Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
Nature Medicine, 2015, 21, 457-466
39.5258Citations (PDF)
84The PTEN Tumor Suppressor Forms Homodimers in Solution
Structure, 2015, 23, 1952-1957
3.838Citations (PDF)
85PTEN mediates Notch-dependent stalk cell arrest in angiogenesis
Nature Communications, 2015, 6,
13.997Citations (PDF)
86SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
Molecular Cell, 2015, 59, 917-930
13.4199Citations (PDF)
87Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity
Cell, 2015, 163, 1400-1412
34.1571Citations (PDF)
88Loss of Wave1 gene defines a subtype of lethal prostate cancer
Oncotarget, 2015, 6, 12383-12391
1.712Citations (PDF)
89Metastasis-associated <i>MCL1</i> and <i>P16</i> copy number alterations dictate resistance to vemurafenib in a <i>BRAFV600E</i> patient-derived papillary thyroid carcinoma preclinical model
Oncotarget, 2015, 6, 42445-42467
1.748Citations (PDF)
90Establishment of a Humanized APL Model via the Transplantation of PML-RARA-Transduced Human Common Myeloid Progenitors into Immunodeficient Mice
PLoS ONE, 2014, 9, e111082
2.49Citations (PDF)
91Of Model Pets and Cancer Models: An Introduction to Mouse Models of Cancer
Cold Spring Harbor Protocols, 2014, 2014, pdb.top069757
0.313Citations (PDF)
92Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
Cell Reports, 2014, 9, 75-89
6.4384Citations (PDF)
93<scp>HIF</scp> factors cooperate with <scp>PML</scp>‐<scp>RAR</scp>α to promote acute promyelocytic leukemia progression and relapse
EMBO Molecular Medicine, 2014, 6, 640-650
7.240Citations (PDF)
94Morgana acts as a proto‐oncogene through inhibition of a <scp>ROCK–PTEN</scp> pathway
Journal of Pathology, 2014, 234, 152-163
5.023Citations (PDF)
95MicroRNAs in the pathogenesis of myelodysplastic syndromes and myeloid leukaemia
Current Opinion in Hematology, 2014, 21, 276-282
2.812Citations (PDF)
96Utility of LRF/Pokemon and NOTCH1 Protein Expression in the Distinction Between Nodular Lymphocyte-Predominant Hodgkin Lymphoma and Classical Hodgkin Lymphoma
International Journal of Surgical Pathology, 2014, 22, 6-11
1.07Citations (PDF)
97NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease
Experimental Hematology, 2014, 42, 101-113.e5
0.434Citations (PDF)
98Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function
Cell, 2014, 157, 595-610
34.1260Citations (PDF)
99The multilayered complexity of ceRNA crosstalk and competition
Nature, 2014, 505, 344-352
38.73,694Citations (PDF)
100Role of BRAFV600E in the First Preclinical Model of Multifocal Infiltrating Myopericytoma Development and Microenvironment
Journal of the National Cancer Institute, 2014, 106,
4.738Citations (PDF)
101Dok1 and Dok2 proteins regulate natural killer cell development and function
EMBO Journal, 2014, 33, 1928-1940
7.443Citations (PDF)
102Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells
Cell Metabolism, 2014, 19, 795-809
26.2469Citations (PDF)
103Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance
Cell Stem Cell, 2014, 14, 329-341
16.8185Citations (PDF)
104Bone Marrow Endosteal Mesenchymal Progenitors Depend on HIF Factors for Maintenance and Regulation of Hematopoiesis
Stem Cell Reports, 2014, 2, 794-809
4.527Citations (PDF)
105The Tumor Suppressor PML Specifically Accumulates at RPA/Rad51-Containing DNA Damage Repair Foci but Is Nonessential for DNA Damage-Induced Fibroblast Senescence
Molecular and Cellular Biology, 2014, 34, 1733-1746
2.531Citations (PDF)
106Vulnerabilities of <i>PTEN</i>–<i>TP53</i>-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition
Cancer Discovery, 2014, 4, 896-904
25.693Citations (PDF)
107hnRNP K Overexpression Synergizes with Mutant NPM1 to Drive Acute Myeloid Leukemia Progression
Blood, 2014, 124, 2382-2382
4.21Citations (PDF)
108The BRAF Pseudogene Is a Proto-Oncogenic Competitive Endogenous RNA
Blood, 2014, 124, 263-263
4.22Citations (PDF)
109Role of aberrant PI3K pathway activation in gallbladder tumorigenesis
Oncotarget, 2014, 5, 894-900
1.753Citations (PDF)
110Abstract B06: Abi1 levels regulate prostate tumor progression in mice downstream from Pten inactivation
2014, ,
0Citations (PDF)
111In Vivo Analysis of PML-RARA in a Humanized Mouse Model
Blood, 2014, 124, 1020-1020
4.28Citations (PDF)
112The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation
Cell Stem Cell, 2013, 13, 87-101
16.8303Citations (PDF)
113ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry
Cancer Discovery, 2013, 3, 1113-1121
25.6821Citations (PDF)
114Role of LRF/Pokemon in lineage fate decisions
Blood, 2013, 121, 2845-2853
4.263Citations (PDF)
115Characterization and Analysis of the Composition and Dynamics of the Mammalian Riboproteome
Cell Reports, 2013, 4, 1276-1287
6.454Citations (PDF)
116Dual Pten/Tp53 Suppression Promotes Sarcoma Progression by Activating Notch Signaling
American Journal of Pathology, 2013, 182, 2015-2027
3.423Citations (PDF)
117Cancer metabolism: fatty acid oxidation in the limelight
Nature Reviews Cancer, 2013, 13, 227-232
61.81,192Citations (PDF)
118Noncoding RNAs and Cancer
Cell, 2013, 153, 9-10
34.143Citations (PDF)
119Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110, 7154-7159
7.6329Citations (PDF)
120The Mitochondrial Italian Human Proteome Project Initiative (mt-HPP)
Molecular BioSystems, 2013, ,
3.210Citations (PDF)
121A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
Nature Genetics, 2013, 45, 747-755
26.1142Citations (PDF)
122Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion
Nature Genetics, 2013, 45, 739-746
26.1143Citations (PDF)
123MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling
Cell, 2013, 154, 311-324
34.1435Citations (PDF)
124Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth
Cancer Research, 2013, 73, 7009-7021
0.6360Citations (PDF)
125Gata3 antagonizes cancer progression in Pten-deficient prostates
Human Molecular Genetics, 2013, 22, 2400-2410
3.041Citations (PDF)
126Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia
Journal of Experimental Medicine, 2013, 210, 2793-2802
9.4133Citations (PDF)
127MUC1 Is a Potential Target for the Treatment of Acute Myeloid Leukemia Stem Cells
Cancer Research, 2013, 73, 5569-5579
0.652Citations (PDF)
128Effective Utilization and Appropriate Selection of Genetically Engineered Mouse Models for Translational Integration of Mouse and Human Trials
Cold Spring Harbor Protocols, 2013, 2013, pdb.top078774
0.315Citations (PDF)
129The RNA Binding Protein ESRP1 Fine-Tunes the Expression of Pluripotency-Related Factors in Mouse Embryonic Stem Cells
PLoS ONE, 2013, 8, e72300
2.442Citations (PDF)
130DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma
PLoS ONE, 2013, 8, e79526
2.414Citations (PDF)
131The Lilliputians and the Giant: An Emerging Oncogenic microRNA Network that Suppresses the PTEN Tumor Suppressor In Vivo
MicroRNA (Shariqah, United Arab Emirates), 2013, 2, 127-136
1.213Citations (PDF)
132ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications
Blood, 2013, 122, SCI-30-SCI-30
4.20Citations (PDF)
133Compound In Vivo Inactivation of Pml and p53 Uncovers a Functional Interaction in Angiosarcoma Suppression
Genes and Cancer, 2012, 3, 599-603
3.84Citations (PDF)
134Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109, 2561-2566
7.662Citations (PDF)
135E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis
Blood, 2012, 120, 822-832
4.255Citations (PDF)
136Functional Antagonism between Sall4 and Plzf Defines Germline Progenitors
Cell Stem Cell, 2012, 10, 284-298
16.8177Citations (PDF)
137A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
Nature Medicine, 2012, 18, 1350-1358
39.5704Citations (PDF)
138Up-regulation of Translation Eukaryotic Initiation Factor 4E in Nucleophosmin 1 Haploinsufficient Cells Results in Changes in CCAAT Enhancer-binding Protein α Activity
Journal of Biological Chemistry, 2012, 287, 32728-32737
2.217Citations (PDF)
139Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
Cell, 2012, 149, 49-62
34.1375Citations (PDF)
140Acetylation-Dependent Regulation of Skp2 Function
Cell, 2012, 150, 179-193
34.1203Citations (PDF)
141Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing <i>Ink4a-Arf</i> Locus
Science Signaling, 2012, 5,
5.559Citations (PDF)
142Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
Cancer Discovery, 2012, 2, 1048-1063
25.6426Citations (PDF)
143CIP2A Promotes Proliferation of Spermatogonial Progenitor Cells and Spermatogenesis in Mice
PLoS ONE, 2012, 7, e33209
2.452Citations (PDF)
144Promyelocytic Leukemia Zinc Finger Protein Activates GATA4 Transcription and Mediates Cardiac Hypertrophic Signaling from Angiotensin II Receptor 2
PLoS ONE, 2012, 7, e35632
2.444Citations (PDF)
145The functions and regulation of the PTEN tumour suppressor
Nature Reviews Molecular Cell Biology, 2012, 13, 283-296
78.91,787Citations (PDF)
146Dosage and tumour suppression
Journal of Pathology, 2012, 227, e1-e1
5.00Citations (PDF)
147Dok‐1 overexpression promotes development of γδ natural killer <scp>T</scp> cells
European Journal of Immunology, 2012, 42, 2491-2504
3.26Citations (PDF)
148Translation‐dependent mechanisms lead to PML upregulation and mediate oncogenic K‐RAS‐induced cellular senescence
EMBO Molecular Medicine, 2012, 4, 594-602
7.229Citations (PDF)
149Targeting Leukemia Initiating Cells by MUC1-C Subunit Inhibition
Blood, 2012, 120, 3583-3583
4.20Citations (PDF)
150A PML–PPAR-δ Pathway for Fatty Acid Oxidation Regulates Hematopoietic Stem Cell Maintenance Through the Control of Asymmetric Division.
Blood, 2012, 120, 2327-2327
4.26Citations (PDF)
151A continuum model for tumour suppression
Nature, 2011, 476, 163-169
38.7466Citations (PDF)
152Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner
Cell, 2011, 144, 187-199
34.1356Citations (PDF)
153Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs
Cell, 2011, 147, 344-357
34.1989Citations (PDF)
154In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma
Cell, 2011, 147, 382-395
34.1636Citations (PDF)
155Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma
PLoS ONE, 2011, 6, e19103
2.465Citations (PDF)
156Functional Connection between Rad51 and PML in Homology-Directed Repair
PLoS ONE, 2011, 6, e25814
2.448Citations (PDF)
157Pro-senescence therapy for cancer treatment
Nature Reviews Cancer, 2011, 11, 503-511
61.8435Citations (PDF)
158SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
Cancer Cell, 2011, 19, 416-428
38.5752Citations (PDF)
159Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis
Cancer Cell, 2011, 20, 635-648
38.5220Citations (PDF)
160The nuclear bodies inside out: PML conquers the cytoplasm
Current Opinion in Cell Biology, 2011, 23, 360-366
3.938Citations (PDF)
161Haplo‐insufficiency: a driving force in cancer
Journal of Pathology, 2011, 223, 138-147
5.0111Citations (PDF)
162Pml represses tumour progression through inhibition of mTOR
EMBO Molecular Medicine, 2011, 3, 249-257
7.219Citations (PDF)
163Cellular Senescence as a Possible Mechanism for Halting Progression of Keloid Lesions
Genes and Cancer, 2011, 2, 1061-1066
3.828Citations (PDF)
164Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis
Laboratory Investigation, 2011, 91, 1298-1303
3.38Citations (PDF)
165Differential Expression of S6K2 Dictates Tissue-Specific Requirement for S6K1 in Mediating Aberrant mTORC1 Signaling and Tumorigenesis
Cancer Research, 2011, 71, 3669-3675
0.621Citations (PDF)
166Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors
Science Signaling, 2011, 4,
5.5169Citations (PDF)
167PTEN Level in Tumor Suppression: How Much Is Too Little?
Cancer Research, 2011, 71, 629-633
0.6234Citations (PDF)
168A Role for PML in Innate Immunity
Genes and Cancer, 2011, 2, 10-19
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169Treatment with 5-Azacytidine Accelerates Acute Promyelocytic Leukemia Leukemogenesis in a Transgenic Mouse Model
Genes and Cancer, 2011, 2, 160-165
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170Upregulation of eIF4E in Nucleophosmin 1 (NPM1) Haploinsufficient Cells Alters CCAAT Enhancer Binding Protein Alpha (C/EBPα) Activity: Implications for MDS and AML
Blood, 2011, 118, 2432-2432
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171Generation of Functional Hepatocytes From Mouse Germ Line Cell-Derived Pluripotent Stem Cells In Vitro
Stem Cells and Development, 2010, 19, 1183-1194
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172Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
Nature, 2010, 464, 374-379
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173A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Nature, 2010, 465, 1033-1038
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174Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
Nature Cell Biology, 2010, 12, 457-467
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175Identification of DOK genes as lung tumor suppressors
Nature Genetics, 2010, 42, 216-223
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176The TLX1 oncogene drives aneuploidy in T cell transformation
Nature Medicine, 2010, 16, 1321-1327
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177Development of Promyelocytic Zinc Finger and ThPOK-Expressing Innate γδ T Cells Is Controlled by Strength of TCR Signaling and Id3
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178eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107, 14134-14139
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179CD8 T Cell-Intrinsic GITR Is Required for T Cell Clonal Expansion and Mouse Survival following Severe Influenza Infection
Journal of Immunology, 2010, 185, 7223-7234
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180Identification of the <i>miR-106b</i> ~ <i>25</i> MicroRNA Cluster as a Proto-Oncogenic <i>PTEN</i> -Targeting Intron That Cooperates with Its Host Gene <i>MCM7</i> in Transformation
Science Signaling, 2010, 3,
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181Morgana/chp-1, a ROCK Inhibitor Involved in Centrosome Duplication and Tumorigenesis
Developmental Cell, 2010, 18, 486-495
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182Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1
Cell, 2010, 142, 468-479
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183A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
Journal of Clinical Investigation, 2010, 120, 681-693
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184Cytoplasmic Nucleophosmin (NPMc+) Mutations and FMS-Like Tyrosine Kinase 3 (Flt3) Internal Tandem Duplication (ITD) Mutations Cooperate to Cause Leukemia In a Mouse Model
Blood, 2010, 116, 145-145
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185Targeting Acute Myeloid Leukemia Stem Cells by MUC1-C Subunit Inhibition
Blood, 2010, 116, 848-848
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186The Role of Nucleophosmin In Hematopoietic Stem Cells and the Pathogenesis of Myelodysplastic Syndrome
Blood, 2010, 116, 95-95
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187Shape-shifting and tumor suppression by PLZF
Oncotarget, 2010, 1, 3-5
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188BCL11B Mutations In T-Cell Acute Lymphoblastic Leukemia
Blood, 2010, 116, 471-471
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189A Dual Proto-Oncogenic and Tumor Suppressive Role of LRF/POKEMON In Hemopoietic Malignancies through Control of Cell Fate Decision
Blood, 2010, 116, SCI-14-SCI-14
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190TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity
Proceedings of the National Academy of Sciences of the United States of America, 2009, 106, 12453-12458
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191Differential p53-Independent Outcomes of p19 <sup>Arf</sup> Loss in Oncogenesis
Science Signaling, 2009, 2,
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192Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
Journal of Clinical Investigation, 2009, 119, 1359-1372
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193Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
Cancer Cell, 2009, 16, 115-125
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194Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity
Immunity, 2009, 30, 802-816
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195Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
Nature Cell Biology, 2009, 11, 420-432
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196LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis
Developmental Cell, 2009, 17, 527-540
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197A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell
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198Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis
Science Signaling, 2009, 2,
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199Akt-Mediated Phosphorylation of Bmi1 Regulates Its Chromatin Association and Growth Promoting Properties.
Blood, 2009, 114, 3605-3605
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200Nucleophosmin Is Required for Macrophage Function and Maturation.
Blood, 2009, 114, 238-238
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201PML targeting eradicates quiescent leukaemia-initiating cells
Nature, 2008, 453, 1072-1078
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202The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions
Nature Immunology, 2008, 9, 1055-1064
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203Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Nature Medicine, 2008, 14, 1333-1342
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204Tenets of PTEN Tumor Suppression
Cell, 2008, 133, 403-414
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205SnapShot: PTEN Signaling Pathways
Cell, 2008, 133, 550-550.e1
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206Acetylation of PML Is Involved in Histone Deacetylase Inhibitor-mediated Apoptosis
Journal of Biological Chemistry, 2008, 283, 24420-24425
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207Aberrant <i>Rheb</i>-mediated mTORC1 activation and <i>Pten</i> haploinsufficiency are cooperative oncogenic events
Genes and Development, 2008, 22, 2172-2177
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208Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome
Molecular and Cellular Biology, 2008, 28, 7050-7065
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209Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
Journal of Clinical Investigation, 2008, ,
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210PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
Genes and Development, 2008, 22, 436-448
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211The Proto-Oncogene LRF Is under Post-Transcriptional Control of MiR-20a: Implications for Senescence
PLoS ONE, 2008, 3, e2542
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212Generation of a Factor Dependent Myeloid Cell Line from Nucleophosmin-1 Heterozygous (NPM-1+/−) Mouse Bone Marrow as a Model for 5q- MDS
Blood, 2008, 112, 852-852
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213PML-Retinoic Acid Receptor α Inhibits PML IV Enhancement of PU.1-Induced C/EBPε Expression in Myeloid Differentiation
Molecular and Cellular Biology, 2007, 27, 5819-5834
2.543Citations (PDF)
214Repression of kit Expression by Plzf in Germ Cells
Molecular and Cellular Biology, 2007, 27, 6770-6781
2.5191Citations (PDF)
215NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN
Cell, 2007, 128, 129-139
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216Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression
Cell, 2007, 128, 141-156
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217Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity
Cell, 2007, 128, 157-170
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218Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
Nature Reviews Molecular Cell Biology, 2007, 8, 1006-1016
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219A CK2-Dependent Mechanism for Degradation of the PML Tumor Suppressor
Cell, 2006, 126, 269-283
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220The Mechanisms of PML-Nuclear Body Formation
Molecular Cell, 2006, 24, 331-339
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221Nucleophosmin and cancer
Nature Reviews Cancer, 2006, 6, 493-505
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222PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR
Nature, 2006, 442, 779-785
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223Dok-1 Independently Attenuates Ras/Mitogen-Activated Protein Kinase and Src/c-Myc Pathways To Inhibit Platelet-Derived Growth Factor-Induced Mitogenesis
Molecular and Cellular Biology, 2006, 26, 2479-2489
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224p18 Ink4c and Pten Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle Control
Molecular and Cellular Biology, 2006, 26, 4564-4576
2.544Citations (PDF)
225A Novel Signal Transduction Cascade Involving Direct Physical Interaction of the Renin/Prorenin Receptor With the Transcription Factor Promyelocytic Zinc Finger Protein
Circulation Research, 2006, 99, 1355-1366
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226The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
Genes and Development, 2006, 20, 1569-1574
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227Downstream of Tyrosine Kinases-1 and Src Homology 2-Containing Inositol 5′-Phosphatase Are Required for Regulation of CD4+CD25+ T Cell Development
Journal of Immunology, 2006, 176, 3958-3965
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228Stromal cell–derived factor-1α/CXCL12–induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1
Blood, 2005, 105, 474-480
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229The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage
Blood, 2005, 105, 3686-3690
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230Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
Genes and Development, 2005, 19, 1779-1786
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231The Transcription Factor Pokemon: A New Key Player in Cancer Pathogenesis: Figure 1.
Cancer Research, 2005, 65, 8575-8578
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232Role of the proto-oncogene Pokemon in cellular transformation and ARF repression
Nature, 2005, 433, 278-285
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233Phosphorylation and Functional Inactivation of TSC2 by Erk
Cell, 2005, 121, 179-193
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234The SUMO Pathway Is Essential for Nuclear Integrity and Chromosome Segregation in Mice
Developmental Cell, 2005, 9, 769-779
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235Loss of the Tumor Suppressor PML in Human Cancers of Multiple Histologic Origins
Journal of the National Cancer Institute, 2004, 96, 269-279
4.7315Citations (PDF)
236The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Nature Medicine, 2004, 10, 484-486
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237Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARα
Oncogene, 2004, 23, 665-678
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238Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age
Oncogene, 2004, 23, 3134-3137
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239Breast Cancer — Loss of PTEN Predicts Resistance to Treatment
New England Journal of Medicine, 2004, 351, 2337-2338
43.7156Citations (PDF)
240PML Is a Direct p53 Target that Modulates p53 Effector Functions
Molecular Cell, 2004, 13, 523-535
13.4305Citations (PDF)
241Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia
Blood, 2004, 103, 2358-2362
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242Role of PML and the PML-nuclear body in the control of programmed cell death
Oncogene, 2003, 22, 9048-9057
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243Does the ribosome translate cancer?
Nature Reviews Cancer, 2003, 3, 179-192
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244The Promyelocytic Leukemia Protein Protects p53 from Mdm2-mediated Inhibition and Degradation
Journal of Biological Chemistry, 2003, 278, 33134-33141
2.2127Citations (PDF)
245Pten Dose Dictates Cancer Progression in the Prostate
PLoS Biology, 2003, 1, e59
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246Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice
Blood, 2002, 100, 238-245
4.2398Citations (PDF)
247The Role of PML in Tumor Suppression
Cell, 2002, 108, 165-170
34.1534Citations (PDF)
248Plzf Mediates Transcriptional Repression of HoxD Gene Expression through Chromatin Remodeling
Developmental Cell, 2002, 3, 499-510
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249Activation of Akt/Protein Kinase B Overcomes a G<sub>2</sub>/M Cell Cycle Checkpoint Induced by DNA Damage
Molecular and Cellular Biology, 2002, 22, 7831-7841
2.5273Citations (PDF)
250Regulation of Pax3 transcriptional activity by SUMO-1-modified PML
Oncogene, 2001, 20, 1-9
6.7107Citations (PDF)
251Transcription therapy for cancer
Oncogene, 2001, 20, 3116-3127
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252In vivo analysis of the molecular genetics of acute promyelocytic leukemia
Oncogene, 2001, 20, 5726-5735
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253The theory of APL
Oncogene, 2001, 20, 7216-7222
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254Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as2O3-Induced Pml or Pml/Retinoic Acid Receptor α Degradation
Journal of Experimental Medicine, 2001, 193, 1361-1372
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255Phosphoinositide 3-Kinase–Dependent Membrane Recruitment of P62dok Is Essential for Its Negative Effect on Mitogen-Activated Protein (Map) Kinase Activation
Journal of Experimental Medicine, 2001, 194, 265-274
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256P62dok, a Negative Regulator of Ras and Mitogen-Activated Protein Kinase (Mapk) Activity, Opposes Leukemogenesis by P210bcr-abl
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257Role of the Promyelocytic Leukemia Protein PML in the Interferon Sensitivity of Lymphocytic Choriomeningitis Virus
Journal of Virology, 2001, 75, 6204-6208
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258Role of Promyelocytic Leukemia (Pml) Protein in Tumor Suppression
Journal of Experimental Medicine, 2001, 193, 521-530
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259Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
Journal of Clinical Investigation, 2001, 108, 1321-1330
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260A role for PML and the nuclear body in genomic stability
Oncogene, 2000, 18, 7941-7947
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261The puzzling multiple lives of PML and its role in the genesis of cancer
BioEssays, 2000, 22, 827-835
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262Plzf regulates limb and axial skeletal patterning
Nature Genetics, 2000, 25, 166-172
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263The transcriptional role of PML and the nuclear body
Nature Cell Biology, 2000, 2, E85-E90
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264The function of PML in p53-dependent apoptosis
Nature Cell Biology, 2000, 2, 730-736
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265Role of SUMO-1–modified PML in nuclear body formation
Blood, 2000, 95, 2748-2752
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266Promyelocytic Leukemia Protein (Pml) and Daxx Participate in a Novel Nuclear Pathway for Apoptosis
Journal of Experimental Medicine, 2000, 191, 631-640
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267Two Critical Hits for Promyelocytic Leukemia
Molecular Cell, 2000, 6, 1131-1141
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268The Multiple Roles of PTEN in Tumor Suppression
Cell, 2000, 100, 387-390
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269A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARα and T18 oncoproteins
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270In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications
Oncogene, 1999, 18, 5278-5292
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271Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27<sup>Kip1</sup> Activity
Molecular and Cellular Biology, 1999, 19, 7011-7019
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272Pml is essential for multiple apoptotic pathways
Nature Genetics, 1998, 20, 266-272
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273Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
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274Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide
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275Molecular Cloning and Characterization of p56 Defines a New Family of RasGAP-binding Proteins
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276Acute Promyelocytic Leukemia as a Model for Cross-Talk Between Interferon and Retinoic Acid Pathways: From Molecular Biology to Clinical Applications
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277Title is missing!
Transgenic Research, 1997, 6, 321-328
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278Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia
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279Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis
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280G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L
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