| 1 | Prime editing in plants: prospects and challenges | 5.1 | 16 | Citations (PDF) |
| 2 | Dual activities of an X-family DNA polymerase regulate CRISPR-induced insertional mutagenesis across species | 13.9 | 6 | Citations (PDF) |
| 3 | An extensible vector toolkit and parts library for advanced engineering of plant genomes | 3.3 | 27 | Citations (PDF) |
| 4 | Efficient protein tagging and <i>cis</i>-regulatory element engineering via precise and directional oligonucleotide-based targeted insertion in plants | 7.6 | 30 | Citations (PDF) |
| 5 | Genome editing and chromosome engineering in plants | 3.3 | 4 | Citations (PDF) |
| 6 | Modulation of Immune Reaction in Hydrodynamic Gene Therapy for Hemophilia A | 3.2 | 4 | Citations (PDF) |
| 7 | Modified strict sperm morphology threshold aids in the clinical selection of conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) | 2.1 | 7 | Citations (PDF) |
| 8 | scMAGIC: accurately annotating single cells using two rounds of reference-based classification | 15.7 | 18 | Citations (PDF) |
| 9 | Efficiency, Specificity and Temperature Sensitivity of Cas9 and Cas12a RNPs for DNA-free Genome Editing in Plants | 4.2 | 23 | Citations (PDF) |
| 10 | CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling | 6.4 | 35 | Citations (PDF) |
| 11 | Improved and Flexible HDR Editing by Targeting Introns in iPSCs | 4.1 | 15 | Citations (PDF) |
| 12 | Basic Phenotyping of Male Fertility from 2019 to 2020 at the Human Sperm Bank of Fudan University | 5.4 | 0 | Citations (PDF) |
| 13 | Whole-Exome Sequencing Identifies the VHL Mutation (c.262T > C, p.Try88Arg) in Non-Obstructive Azoospermia-Associated Cystic Renal Cell Carcinoma | 3.1 | 3 | Citations (PDF) |
| 14 | POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function | 6.4 | 22 | Citations (PDF) |
| 15 | Genome‐wide loss of <scp>CHH</scp> methylation with limited transcriptome changes in <i>Setaria viridis</i> DOMAINS REARRANGED METHYLTRANSFERASE (<scp>DRM</scp>) mutants | 6.2 | 8 | Citations (PDF) |
| 16 | “Progressive motility” in elucidating novel genetic causes of male infertility | 2.1 | 0 | Citations (PDF) |
| 17 | Evaluation of inactivated COVID-19 vaccine on semen parameters in reproductive-age males: a retrospective cohort study | 2.1 | 27 | Citations (PDF) |
| 18 | UG/Abi: a highly diverse family of prokaryotic reverse transcriptases associated with defense functions | 15.7 | 40 | Citations (PDF) |
| 19 | Epigenetic features drastically impact CRISPR–Cas9 efficacy in plants | 5.5 | 63 | Citations (PDF) |
| 20 | OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes | 1.1 | 10 | Citations (PDF) |
| 21 | Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of<i>Angptl3</i> | 7.6 | 347 | Citations (PDF) |
| 22 | Dual modes of CRISPR-associated transposon homingCell, 2021, 184, 2441-2453.e18 | 34.1 | 131 | Citations (PDF) |
| 23 | A cellular and spatial map of the choroid plexus across brain ventricles and agesCell, 2021, 184, 3056-3074.e21 | 34.1 | 319 | Citations (PDF) |
| 24 | CRISPR-based diagnostics | 22.6 | 1,077 | Citations (PDF) |
| 25 | Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion | 8.2 | 57 | Citations (PDF) |
| 26 | Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells | 16.8 | 155 | Citations (PDF) |
| 27 | Adaptive responses to
<i>mTOR</i>
gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition | 7.6 | 30 | Citations (PDF) |
| 28 | Nanomedicine potentiates mild photothermal therapy for tumor ablation | 9.1 | 98 | Citations (PDF) |
| 29 | CRISPR/Cas9 Delivery System Engineering for Genome Editing in Therapeutic Applications | 5.1 | 77 | Citations (PDF) |
| 30 | Genetic analysis of osteopetrosis in Pakistani families identifies novel and known sequence variants | 1.8 | 4 | Citations (PDF) |
| 31 | Cargo Genes of Tn
<i>7</i>
-Like Transposons Comprise an Enormous Diversity of Defense Systems, Mobile Genetic Elements, and Antibiotic Resistance Genes | 4.4 | 60 | Citations (PDF) |
| 32 | A Survey of Genome Editing Activity for 16 Cas12a Orthologs | 1.6 | 65 | Citations (PDF) |
| 33 | Clinical characteristics of recovered COVID-19 patients with re-detectable positive RNA test | 1.8 | 134 | Citations (PDF) |
| 34 | Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity | 13.4 | 134 | Citations (PDF) |
| 35 | Optimization of multiplexed CRISPR/Cas9 system for highly efficient genome editing in <i>Setaria viridis</i> | 6.2 | 77 | Citations (PDF) |
| 36 | β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund’s adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway | 7.7 | 91 | Citations (PDF) |
| 37 | Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA | 22.6 | 603 | Citations (PDF) |
| 38 | CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair | 13.9 | 43 | Citations (PDF) |
| 39 | Review: Computational Identification of Repeat-containing Proteins and Systems — R0/PR2 2020, , | | 0 | Citations (PDF) |
| 40 | Rapid and accurate species identification for ecological studies and monitoring using CRISPR‐based SHERLOCK | 4.8 | 60 | Citations (PDF) |
| 41 | Highly Parallel Profiling of Cas9 Variant Specificity | 13.4 | 184 | Citations (PDF) |
| 42 | CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors | 34.1 | 458 | Citations (PDF) |
| 43 | A novel hemizygous loss-of-function mutation in ADGRG2 causes male infertility with congenital bilateral absence of the vas deferens | 2.5 | 19 | Citations (PDF) |
| 44 | “Response to the letter to the editor “Concerns regarding the potentially causal role of FANCA heterozygous variants in human primary ovarian insufficiency”” | 3.0 | 2 | Citations (PDF) |
| 45 | Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay | 2.4 | 68 | Citations (PDF) |
| 46 | CRISPR Tools for Systematic Studies of RNA Regulation | 7.3 | 28 | Citations (PDF) |
| 47 | Carboxypeptidase A4 promotes migration and invasion of lung cancer cells, and is closely associated with lymph node metastasis | 1.9 | 0 | Citations (PDF) |
| 48 | Modulating gene translational control through genome editing | 9.8 | 2 | Citations (PDF) |
| 49 | DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical ReactionCell, 2019, 178, 229-241.e16 | 34.1 | 101 | Citations (PDF) |
| 50 | Nucleic Acid Detection of Plant Genes Using CRISPR-Cas13 | 3.5 | 114 | Citations (PDF) |
| 51 | Optical Pooled Screens in Human CellsCell, 2019, 179, 787-799.e17 | 34.1 | 296 | Citations (PDF) |
| 52 | Programmable Inhibition and Detection of RNA Viruses Using Cas13 | 13.4 | 361 | Citations (PDF) |
| 53 | Engineering of CRISPR-Cas12b for human genome editing | 13.9 | 325 | Citations (PDF) |
| 54 | Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9 | 13.9 | 49 | Citations (PDF) |
| 55 | Unexpected connections between type VI-B CRISPR-Cas systems, bacterial natural competence, ubiquitin signaling network and DNA modification through a distinct family of membrane proteins | 1.9 | 19 | Citations (PDF) |
| 56 | High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage | 6.4 | 130 | Citations (PDF) |
| 57 | Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis | 16.8 | 199 | Citations (PDF) |
| 58 | Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination | 15.7 | 14 | Citations (PDF) |
| 59 | Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring | 2.0 | 30 | Citations (PDF) |
| 60 | The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens | 8.2 | 403 | Citations (PDF) |
| 61 | Curing hemophilia A by NHEJ-mediated ectopic F8 insertion in the mouse | 8.2 | 61 | Citations (PDF) |
| 62 | MEOX1 Promotes Tumor Progression and Predicts Poor Prognosis in Human Non-Small-Cell Lung Cancer | 2.9 | 18 | Citations (PDF) |
| 63 | Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons | 22.6 | 96 | Citations (PDF) |
| 64 | MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis | 5.0 | 16 | Citations (PDF) |
| 65 | Clinical outcomes of arthroscopic synovectomy for adolescent or young adult patients with advanced haemophilic arthropathy | 2.1 | 5 | Citations (PDF) |
| 66 | LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients | 11.5 | 157 | Citations (PDF) |
| 67 | High-Level Precise Knockin of iPSCs by Simultaneous Reprogramming and Genome Editing of Human Peripheral Blood Mononuclear Cells | 4.5 | 22 | Citations (PDF) |
| 68 | Comparison of the clinical effects of arthroscopic surgery vs. open surgery for grade�II gluteal muscle contracture in adults | 2.1 | 4 | Citations (PDF) |
| 69 | Discovery of proteins associated with a predefined genomic locus via dCas9–APEX-mediated proximity labeling | 25.9 | 185 | Citations (PDF) |
| 70 | Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair | 7.8 | 149 | Citations (PDF) |
| 71 | Diversity and evolution of class 2 CRISPR–Cas systems | 85.9 | 983 | Citations (PDF) |
| 72 | SnapShot: Class 2 CRISPR-Cas SystemsCell, 2017, 168, 328-328.e1 | 34.1 | 164 | Citations (PDF) |
| 73 | Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits | 6.4 | 222 | Citations (PDF) |
| 74 | BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks | 13.9 | 369 | Citations (PDF) |
| 75 | Coupling immunity and programmed cell suicide in prokaryotes: Life‐or‐death choices | 2.2 | 89 | Citations (PDF) |
| 76 | Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1 | 13.4 | 108 | Citations (PDF) |
| 77 | Diversity, classification and evolution of CRISPR-Cas systems | 7.0 | 1,357 | Citations (PDF) |
| 78 | Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems | 13.4 | 179 | Citations (PDF) |
| 79 | IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization | 7.6 | 29 | Citations (PDF) |
| 80 | Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28 | 13.4 | 549 | Citations (PDF) |
| 81 | Implications of human genetic variation in CRISPR-based therapeutic genome editing | 39.5 | 128 | Citations (PDF) |
| 82 | Identification of essential genes for cancer immunotherapy | 38.7 | 822 | Citations (PDF) |
| 83 | AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma | 17.1 | 229 | Citations (PDF) |
| 84 | Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1 | 13.4 | 287 | Citations (PDF) |
| 85 | Massively parallel single-nucleus RNA-seq with DroNc-seq | 25.9 | 1,079 | Citations (PDF) |
| 86 | Analysis of the Fragile X Mental Retardation 1 Premutation in Han Chinese Women Presenting with Primary Ovarian Insufficiency | 0.6 | 3 | Citations (PDF) |
| 87 | Genome-Wide Identification of Regulatory Sequences Undergoing Accelerated Evolution in the Human Genome | 4.7 | 74 | Citations (PDF) |
| 88 | Multiplexed, targeted gene editing in <i>Nicotiana benthamiana</i> for glyco‐engineering and monoclonal antibody production | 8.8 | 103 | Citations (PDF) |
| 89 | Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA | 34.1 | 731 | Citations (PDF) |
| 90 | Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems | 36.4 | 619 | Citations (PDF) |
| 91 | An RNA-aptamer-based two-color CRISPR labeling system | 3.5 | 101 | Citations (PDF) |
| 92 | The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells | 2.2 | 30 | Citations (PDF) |
| 93 | Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects | 11.1 | 325 | Citations (PDF) |
| 94 | Structure and Engineering of Francisella novicida Cas9 | 34.1 | 352 | Citations (PDF) |
| 95 | Hypoxia as a therapy for mitochondrial disease | 36.4 | 427 | Citations (PDF) |
| 96 | Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array | 32.2 | 876 | Citations (PDF) |
| 97 | Multidimensional chemical control of CRISPR–Cas9 | 12.0 | 178 | Citations (PDF) |
| 98 | CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus | 3.5 | 274 | Citations (PDF) |
| 99 | Sequence determinants of improved CRISPR sgRNA design | 4.6 | 618 | Citations (PDF) |
| 100 | Therapeutic genome editing: prospects and challenges | 39.5 | 1,221 | Citations (PDF) |
| 101 | Establishment and development of the personalized criteria for microscopic review following multiple automated routine urinalysis systems | 1.6 | 20 | Citations (PDF) |
| 102 | Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and MetastasisCell, 2015, 160, 1246-1260 | 34.1 | 877 | Citations (PDF) |
| 103 | A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks | 34.1 | 443 | Citations (PDF) |
| 104 | Non-transgenic Plant Genome Editing Using Purified Sequence-Specific Nucleases | 19.0 | 57 | Citations (PDF) |
| 105 | In vivo genome editing using Staphylococcus aureus Cas9 | 38.7 | 2,577 | Citations (PDF) |
| 106 | Correlation between frequency of non-allelic homologous recombination and homology properties: evidence from homology-mediated CNV mutations in the human genome | 3.0 | 17 | Citations (PDF) |
| 107 | Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease | 32.2 | 260 | Citations (PDF) |
| 108 | Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System | 34.1 | 4,498 | Citations (PDF) |
| 109 | Assessing structural variation in a personal genome—towards a human reference diploid genome | 3.3 | 160 | Citations (PDF) |
| 110 | Crystal Structure of Staphylococcus aureus Cas9Cell, 2015, 162, 1113-1126 | 34.1 | 426 | Citations (PDF) |
| 111 | BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis | 38.7 | 874 | Citations (PDF) |
| 112 | Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA | 34.1 | 2,051 | Citations (PDF) |
| 113 | CRISPR/Cas9 for genome editing: progress, implications and challenges | 3.0 | 586 | Citations (PDF) |
| 114 | Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells | 36.4 | 428 | Citations (PDF) |
| 115 | Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells | 32.2 | 929 | Citations (PDF) |
| 116 | Global microRNA depletion suppresses tumor angiogenesis | 4.7 | 66 | Citations (PDF) |
| 117 | Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites | 6.4 | 1,162 | Citations (PDF) |
| 118 | Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum | 25.9 | 223 | Citations (PDF) |
| 119 | CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling | 34.1 | 1,915 | Citations (PDF) |
| 120 | Development and Applications of CRISPR-Cas9 for Genome EngineeringCell, 2014, 157, 1262-1278 | 34.1 | 5,308 | Citations (PDF) |
| 121 | Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex | 38.7 | 2,704 | Citations (PDF) |
| 122 | Genome Architecture and Its Roles in Human Copy Number Variation | 1.2 | 32 | Citations (PDF) |
| 123 | Efficient genome editing in plants using a CRISPR/Cas system | 12.5 | 1,048 | Citations (PDF) |
| 124 | Increased genome instability in human DNA segments with self-chains: homology-induced structural variations via replicative mechanisms | 3.0 | 23 | Citations (PDF) |
| 125 | Replicative mechanisms of CNV formation preferentially occur as intrachromosomal events: evidence from Potocki–Lupski duplication syndrome | 3.0 | 16 | Citations (PDF) |
| 126 | RNA-guided editing of bacterial genomes using CRISPR-Cas systems | 32.2 | 2,325 | Citations (PDF) |
| 127 | Increasing frequencies of site-specific mutagenesis and gene targeting in <i>Arabidopsis</i> by manipulating DNA repair pathways | 4.6 | 167 | Citations (PDF) |
| 128 | Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system | 15.7 | 1,134 | Citations (PDF) |
| 129 | Transcription Activator-Like Effector Nucleases Enable Efficient Plant Genome Engineering
| 5.5 | 466 | Citations (PDF) |
| 130 | Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains | 13.9 | 310 | Citations (PDF) |
| 131 | Structural variation of the human genome: mechanisms, assays, and role in male infertility | 2.1 | 34 | Citations (PDF) |
| 132 | Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements | 34.1 | 449 | Citations (PDF) |
| 133 | Potocki-Lupski Syndrome: A Microduplication Syndrome Associated with Oropharyngeal Dysphagia and Failure to Thrive | 2.0 | 40 | Citations (PDF) |
| 134 | Copy number variations in the human genome: their mutational mechanisms and roles in diseases | 0.7 | 6 | Citations (PDF) |
| 135 | Mechanisms for Nonrecurrent Genomic Rearrangements Associated with CMT1A or HNPP: Rare CNVs as a Cause for Missing Heritability | 6.5 | 135 | Citations (PDF) |
| 136 | GJB1/Connexin 32 whole gene deletions in patients with X-linked Charcot–Marie–Tooth disease | 1.0 | 29 | Citations (PDF) |
| 137 | Confounding from cryptic relatedness in haplotype-based association studies | 1.1 | 5 | Citations (PDF) |
| 138 | Genetic Relationships of Ethnic Minorities in Southwest China Revealed by Microsatellite Markers | 2.4 | 13 | Citations (PDF) |
| 139 | High frequency targeted mutagenesis in
<i>Arabidopsis thaliana</i>
using zinc finger nucleases | 7.6 | 380 | Citations (PDF) |
| 140 | The Suppression of CRMP2 Expression by Bone Morphogenetic Protein (BMP)-SMAD Gradient Signaling Controls Multiple Stages of Neuronal Development | 2.2 | 50 | Citations (PDF) |
| 141 | Nucleotide polymorphism of the TNF gene cluster in six Chinese populations | 2.1 | 5 | Citations (PDF) |
| 142 | Complex human chromosomal and genomic rearrangements | 9.9 | 258 | Citations (PDF) |
| 143 | A facile synthesis of goodyeroside A from (S)-malic acid | 0.8 | 4 | Citations (PDF) |
| 144 | Copy Number Variation in Human Health, Disease, and Evolution | 6.8 | 1,152 | Citations (PDF) |
| 145 | Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations | 4.0 | 140 | Citations (PDF) |
| 146 | A spatial analysis of genetic structure of human populations in China reveals distinct difference between maternal and paternal lineages | 3.2 | 49 | Citations (PDF) |
| 147 | Mechanisms for human genomic rearrangements | 2.5 | 582 | Citations (PDF) |
| 148 | Partial blanking of an electron beam using a quadrupole lens | 1.5 | 1 | Citations (PDF) |
| 149 | Nanometer-level stitching in raster-scanning electron-beam lithography using spatial-phase locking | 1.5 | 33 | Citations (PDF) |
| 150 | Two-dimensional spatial-phase-locked electron-beam lithography via sparse sampling | 1.5 | 20 | Citations (PDF) |
