| 1 | Matrix effect evaluation using multi-component post-column infusion in untargeted hydrophilic interaction liquid chromatography-mass spectrometry plasma metabolomics | 3.7 | 13 | Citations (PDF) |
| 2 | Unhealthful plant-based diet associates with frailty risk predominantly in men with low income from the UK Biobank cohort | 3.1 | 7 | Citations (PDF) |
| 3 | German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway | 4.6 | 4 | Citations (PDF) |
| 4 | Exploring geriatricians' perspectives on aging biomarkers: A reflexive thematic analysis | 2.9 | 1 | Citations (PDF) |
| 5 | MC1R and IRF4 Gene Variants Are Associated with p16INK4a-Positive Epidermal Cells | 2.8 | 0 | Citations (PDF) |
| 6 | MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality | 13.7 | 15 | Citations (PDF) |
| 7 | Causal Inference Approaches Reveal Associations Between LDL Oxidation, NO Metabolism, Telomere Length and DNA Integrity Within the MARK-AGE Study | 5.7 | 1 | Citations (PDF) |
| 8 | Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications | 13.7 | 15 | Citations (PDF) |
| 9 | Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications | 13.7 | 55 | Citations (PDF) |
| 10 | Validation of biomarkers of aging | 33.0 | 298 | Citations (PDF) |
| 11 | Epigenome-wide association study of dietary fatty acid intake | 3.9 | 4 | Citations (PDF) |
| 12 | Genome-wide characterization of circulating metabolic biomarkers | 37.9 | 251 | Citations (PDF) |
| 13 | Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data | 2.5 | 35 | Citations (PDF) |
| 14 | Unraveling interindividual variation of trimethylamine N‐oxide and its precursors at the population level | 17.3 | 15 | Citations (PDF) |
| 15 | Late reproduction is associated with extended female survival but not with familial longevity | 2.7 | 2 | Citations (PDF) |
| 16 | A plant-based diet index to study the relation between diet and disease risk among adults: a narrative review | 3.1 | 22 | Citations (PDF) |
| 17 | Physical activity and fiber intake beneficial for muscle mass and strength preservation during aging: A comprehensive cross-sectional study in the UK biobank cohort | 3.7 | 7 | Citations (PDF) |
| 18 | Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial | 13.7 | 7 | Citations (PDF) |
| 19 | A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors | 12.6 | 28 | Citations (PDF) |
| 20 | Increased 1H-NMR metabolomics-based health score associates with declined cognitive performance and functional independence in older adults at risk of cardiovascular disease | 4.6 | 15 | Citations (PDF) |
| 21 | Association between metabolomics-based biomarker scores and 10-year cognitive decline in men and women. The Doetinchem Cohort Study | 1.8 | 4 | Citations (PDF) |
| 22 | Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on
KLF9 | 4.4 | 11 | Citations (PDF) |
| 23 | Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response | 13.7 | 16 | Citations (PDF) |
| 24 | Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project | 4.4 | 20 | Citations (PDF) |
| 25 | Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk | 3.4 | 83 | Citations (PDF) |
| 26 | Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles | 13.7 | 23 | Citations (PDF) |
| 27 | Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification | 25.2 | 96 | Citations (PDF) |
| 28 | Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study | 4.6 | 27 | Citations (PDF) |
| 29 | Technical Report: A Comprehensive Comparison between Different Quantification Versions of Nightingale Health’s 1H-NMR Metabolomics Platform | 3.4 | 20 | Citations (PDF) |
| 30 | Fat metabolism is associated with telomere length in six population-based studies | 2.9 | 13 | Citations (PDF) |
| 31 | A recurrent neural network architecture to model physical activity energy expenditure in older people | 2.7 | 28 | Citations (PDF) |
| 32 | Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression | 8.1 | 72 | Citations (PDF) |
| 33 | Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology | 13.7 | 53 | Citations (PDF) |
| 34 | Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS | 12.5 | 99 | Citations (PDF) |
| 35 | Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways | 2.9 | 11 | Citations (PDF) |
| 36 | DNA methylation in peripheral tissues and left-handedness | 3.4 | 19 | Citations (PDF) |
| 37 | Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index | 4.9 | 42 | Citations (PDF) |
| 38 | Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies | 3.2 | 3 | Citations (PDF) |
| 39 | PLIS
: A metabolomic response monitor to a lifestyle intervention study in older adults | 0.6 | 11 | Citations (PDF) |
| 40 | Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia? | 0.9 | 25 | Citations (PDF) |
| 41 | Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies | 2.6 | 60 | Citations (PDF) |
| 42 | Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers | 2.8 | 20 | Citations (PDF) |
| 43 | Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults | 3.7 | 50 | Citations (PDF) |
| 44 | DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan | 7.8 | 32 | Citations (PDF) |
| 45 | Genome-wide association study of circulating interleukin 6 levels identifies novel loci | 2.9 | 56 | Citations (PDF) |
| 46 | Correction for both common and rare cell types in blood is important to identify genes that correlate with age | 3.2 | 9 | Citations (PDF) |
| 47 | Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses | 7.1 | 26 | Citations (PDF) |
| 48 | Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study | 4.6 | 10 | Citations (PDF) |
| 49 | The trans-ancestral genomic architecture of glycemic traits | 25.2 | 704 | Citations (PDF) |
| 50 | Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study | 2.8 | 4 | Citations (PDF) |
| 51 | Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study | 3.9 | 46 | Citations (PDF) |
| 52 | Association of Thyroid Dysfunction With Cognitive Function | 10.6 | 112 | Citations (PDF) |
| 53 | Identical twins carry a persistent epigenetic signature of early genome programming | 13.7 | 57 | Citations (PDF) |
| 54 | Functional Changes of T-Cell Subsets with Age and CMV Infection | 4.4 | 45 | Citations (PDF) |
| 55 | Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation | 25.2 | 494 | Citations (PDF) |
| 56 | Deciphering osteoarthritis genetics across 826,690 individuals from 9 populationsCell, 2021, 184, 4784-4818.e17 | 33.6 | 384 | Citations (PDF) |
| 57 | Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression | 25.2 | 2,001 | Citations (PDF) |
| 58 | Improved selection of participants in genetic longevity studies: family scores revisited | 2.5 | 6 | Citations (PDF) |
| 59 | Validating biomarkers and models for epigenetic inference of alcohol consumption from blood | 3.9 | 19 | Citations (PDF) |
| 60 | Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling | 7.1 | 25 | Citations (PDF) |
| 61 | Timing of objectively-collected physical activity in relation to body weight and metabolic health in sedentary older people: a cross-sectional and prospective analysis | 3.0 | 34 | Citations (PDF) |
| 62 | Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls | 5.4 | 240 | Citations (PDF) |
| 63 | Heritability estimates for 361 blood metabolites across 40 genome-wide association studies | 13.7 | 96 | Citations (PDF) |
| 64 | Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | 7.7 | 14 | Citations (PDF) |
| 65 | Activity recognition using wearable sensors for tracking the elderly | 1.8 | 57 | Citations (PDF) |
| 66 | Broad phenotype of cysteine-altering
NOTCH3
variants in UK Biobank | 1.0 | 77 | Citations (PDF) |
| 67 | Intergenerational transmission of longevity is not affected by other familial factors:
evidence from 16,905 Dutch families from Zeeland, 1812-1962 | 0.4 | 8 | Citations (PDF) |
| 68 | Metabolic Age Based on the BBMRI-NL
1
H-NMR Metabolomics Repository as Biomarker of Age-related Disease | 2.9 | 110 | Citations (PDF) |
| 69 | Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference | 8.1 | 37 | Citations (PDF) |
| 70 | Association of common genetic variants with brain microbleeds | 1.0 | 93 | Citations (PDF) |
| 71 | The Prognostic Value of Metabolic Profiling in Older Patients With a Proximal Femoral Fracture | 1.4 | 4 | Citations (PDF) |
| 72 | Cerebral small vessel disease genomics and its implications across the lifespan | 13.7 | 202 | Citations (PDF) |
| 73 | Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes | 2.9 | 154 | Citations (PDF) |
| 74 | Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies | 6.8 | 20 | Citations (PDF) |
| 75 | Repeat UVA Exposure of Human Skin Fibroblasts Induces Both a Transitionary and Recovery DNA Methylation Response | 2.2 | 5 | Citations (PDF) |
| 76 | Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity | 2.8 | 11 | Citations (PDF) |
| 77 | Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference | 3.4 | 22 | Citations (PDF) |
| 78 | Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases | 10.9 | 129 | Citations (PDF) |
| 79 | Association of handgrip strength with patient-reported outcome measures after total hip and knee arthroplasty | 2.4 | 11 | Citations (PDF) |
| 80 | Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length | 6.5 | 170 | Citations (PDF) |
| 81 | Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas | 33.0 | 83 | Citations (PDF) |
| 82 | Lifestyle‐Intervention‐Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter | 4.0 | 14 | Citations (PDF) |
| 83 | A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals | 13.7 | 331 | Citations (PDF) |
| 84 | A genome-wide association study identifies genetic loci associated with specific lobar brain volumes | 4.4 | 34 | Citations (PDF) |
| 85 | A meta-analysis of genome-wide association studies identifies multiple longevity genes | 13.7 | 358 | Citations (PDF) |
| 86 | Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium | 3.4 | 19 | Citations (PDF) |
| 87 | Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa | 25.2 | 1,067 | Citations (PDF) |
| 88 | Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction | 7.3 | 239 | Citations (PDF) |
| 89 | Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum | 3.4 | 15 | Citations (PDF) |
| 90 | Validated inference of smoking habits from blood with a finite DNA methylation marker set | 5.3 | 56 | Citations (PDF) |
| 91 | Repeat variations in polyglutamine disease–associated genes and cognitive function in old age | 3.4 | 11 | Citations (PDF) |
| 92 | Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease | 2.8 | 53 | Citations (PDF) |
| 93 | Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk | 13.1 | 175 | Citations (PDF) |
| 94 | Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine | 1.0 | 71 | Citations (PDF) |
| 95 | Frailty Questionnaire Is Not a Strong Prognostic Factor for Functional Outcomes in Hip or Knee Arthroplasty Patients | 1.4 | 9 | Citations (PDF) |
| 96 | L1 drives IFN in senescent cells and promotes age-associated inflammation | 37.9 | 1,225 | Citations (PDF) |
| 97 | Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults | 5.4 | 62 | Citations (PDF) |
| 98 | Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians | 4.4 | 8 | Citations (PDF) |
| 99 | RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage | 6.9 | 168 | Citations (PDF) |
| 100 | Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait | 13.7 | 103 | Citations (PDF) |
| 101 | Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting | 1.0 | 43 | Citations (PDF) |
| 102 | The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors? | 3.4 | 32 | Citations (PDF) |
| 103 | Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study | 4.7 | 40 | Citations (PDF) |
| 104 | Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects | 4.0 | 9 | Citations (PDF) |
| 105 | Stress evokes stronger medial posterior cingulate deactivations during emotional distraction in slower paced aging | 2.5 | 7 | Citations (PDF) |
| 106 | DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood | 10.9 | 270 | Citations (PDF) |
| 107 | Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels | 13.7 | 372 | Citations (PDF) |
| 108 | The Leiden Family Lab study on Social Anxiety Disorder: A multiplex, multigenerational family study on neurocognitive endophenotypes | 2.2 | 23 | Citations (PDF) |
| 109 | Longevity Around the Turn of the 20th Century: Life-Long Sustained Survival Advantage for Parents of Today’s Nonagenarians | 3.4 | 32 | Citations (PDF) |
| 110 | Facial Wrinkles in Europeans: A Genome-Wide Association Study | 2.3 | 17 | Citations (PDF) |
| 111 | DNA methylation signatures of educational attainment | 2.0 | 56 | Citations (PDF) |
| 112 | Survival analysis with delayed entry in selected families with application to human longevity | 1.6 | 10 | Citations (PDF) |
| 113 | IgG glycosylation and DNA methylation are interconnected with smoking | 2.0 | 40 | Citations (PDF) |
| 114 | Phenome and genome based studies into human ageing and longevity: An overview | 4.1 | 46 | Citations (PDF) |
| 115 | Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes | 4.0 | 36 | Citations (PDF) |
| 116 | Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults | 9.7 | 46 | Citations (PDF) |
| 117 | Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation | 13.7 | 270 | Citations (PDF) |
| 118 | Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders | 6.5 | 430 | Citations (PDF) |
| 119 | Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation | 13.7 | 30 | Citations (PDF) |
| 120 | Facing up to the global challenges of ageing | 37.9 | 1,355 | Citations (PDF) |
| 121 | Sex Differences in Genetic Associations With Longevity | 6.6 | 84 | Citations (PDF) |
| 122 | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function | 13.7 | 662 | Citations (PDF) |
| 123 | Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception | 3.2 | 191 | Citations (PDF) |
| 124 | High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes | 3.8 | 9 | Citations (PDF) |
| 125 | Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns | 4.9 | 81 | Citations (PDF) |
| 126 | A characterization of postzygotic mutations identified in monozygotic twins | 4.5 | 16 | Citations (PDF) |
| 127 | Genome-wide identification of directed gene networks using large-scale population genomics data | 13.7 | 28 | Citations (PDF) |
| 128 | Repeat length variations in polyglutamine disease-associated genes affect body mass index | 3.0 | 16 | Citations (PDF) |
| 129 | A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium | 3.8 | 12 | Citations (PDF) |
| 130 | Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice | 3.4 | 52 | Citations (PDF) |
| 131 | Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa | 8.8 | 538 | Citations (PDF) |
| 132 | Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity | 3.4 | 60 | Citations (PDF) |
| 133 | Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits | 13.7 | 202 | Citations (PDF) |
| 134 | Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals | 6.8 | 20 | Citations (PDF) |
| 135 | Automated quantification of metabolites in blood-derived samples by NMR | 5.7 | 27 | Citations (PDF) |
| 136 | Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype | 5.1 | 7 | Citations (PDF) |
| 137 | Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis | 6.5 | 49 | Citations (PDF) |
| 138 | Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health | 3.0 | 65 | Citations (PDF) |
| 139 | Homocysteine Levels Associate With Subtle Changes in Leukocyte DNA Methylation: An Epigenome-Wide Analysis | 2.2 | 8 | Citations (PDF) |
| 140 | Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health | 3.4 | 158 | Citations (PDF) |
| 141 | Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity | 13.7 | 167 | Citations (PDF) |
| 142 | Small nucleoli are a cellular hallmark of longevity | 13.7 | 282 | Citations (PDF) |
| 143 | Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand | 6.9 | 75 | Citations (PDF) |
| 144 | No Causal Association between 25-Hydroxyvitamin D and Features of Skin Aging: Evidence from a Bidirectional Mendelian Randomization Study | 2.3 | 9 | Citations (PDF) |
| 145 | DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation | 6.5 | 206 | Citations (PDF) |
| 146 | High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus | 3.8 | 18 | Citations (PDF) |
| 147 | Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study | 7.5 | 44 | Citations (PDF) |
| 148 | Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire | 2.4 | 26 | Citations (PDF) |
| 149 | Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study | 2.3 | 38 | Citations (PDF) |
| 150 | Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes | 2.3 | 11 | Citations (PDF) |
| 151 | Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men | 3.8 | 2 | Citations (PDF) |
| 152 | Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice | 2.3 | 4 | Citations (PDF) |
| 153 | Classification for Longevity Potential: The Use of Novel Biomarkers | 2.7 | 10 | Citations (PDF) |
| 154 | The multifaceted interplay between lipids and epigenetics | 3.9 | 11 | Citations (PDF) |
| 155 | Meta-analysis of genome-wide association studies of HDL cholesterol response to statins | 3.8 | 35 | Citations (PDF) |
| 156 | Novel loci and pathways significantly associated with longevity | 3.4 | 177 | Citations (PDF) |
| 157 | Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity | 6.8 | 63 | Citations (PDF) |
| 158 | The effect of standardized food intake on the association between BMI and 1H-NMR metabolites | 3.4 | 14 | Citations (PDF) |
| 159 | Liver Fat Assessed With CT Relates to MRI Markers of Incipient Brain Injury in Middle-Aged to Elderly Overweight Persons | 4.1 | 7 | Citations (PDF) |
| 160 | Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2Blood, 2016, 127, 1512-1515 | 5.0 | 48 | Citations (PDF) |
| 161 | Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity | 3.7 | 35 | Citations (PDF) |
| 162 | Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms | 8.1 | 160 | Citations (PDF) |
| 163 | Blood lipids influence DNA methylation in circulating cells | 8.1 | 178 | Citations (PDF) |
| 164 | Genomewide meta‐analysis identifies loci associated with
IGF
‐I and
IGFBP
‐3 levels with impact on age‐related traits | 6.8 | 89 | Citations (PDF) |
| 165 | Copy number variation associates with mortality in long‐lived individuals: a genome‐wide assessment | 6.8 | 22 | Citations (PDF) |
| 166 | Age-dependent expression ofDNMT1andDNMT3Bin PBMCs from a large European population enrolled in the MARK-AGE study | 6.8 | 72 | Citations (PDF) |
| 167 | A reference panel of 64,976 haplotypes for genotype imputation | 25.2 | 3,049 | Citations (PDF) |
| 168 | Genetic and environmental influences interact with age and sex in shaping the human methylome | 13.7 | 391 | Citations (PDF) |
| 169 | Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA | 13.7 | 771 | Citations (PDF) |
| 170 | A high-quality human reference panel reveals the complexity and distribution of genomic structural variants | 13.7 | 111 | Citations (PDF) |
| 171 | Cortical phase changes measured using 7‐T MRI in subjects with subjective cognitive impairment, and their association with cognitive function | 2.4 | 14 | Citations (PDF) |
| 172 | The effect of forced exercise on knee joints in Dio2−/− mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress | 6.9 | 38 | Citations (PDF) |
| 173 | P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age | 3.4 | 88 | Citations (PDF) |
| 174 | Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels | 13.7 | 177 | Citations (PDF) |
| 175 | Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs | 6.6 | 79 | Citations (PDF) |
| 176 | Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck | 4.6 | 96 | Citations (PDF) |
| 177 | A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration | 2.9 | 92 | Citations (PDF) |
| 178 | Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index | 7.8 | 71 | Citations (PDF) |
| 179 | Disease variants alter transcription factor levels and methylation of their binding sites | 25.2 | 469 | Citations (PDF) |
| 180 | Identification of context-dependent expression quantitative trait loci in whole blood | 25.2 | 439 | Citations (PDF) |
| 181 | Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity | 37.9 | 909 | Citations (PDF) |
| 182 | Associations between joint effusion in the knee and gene expression levels in the circulation: a meta-analysis | 0.5 | 7 | Citations (PDF) |
| 183 | Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes | 2.3 | 19 | Citations (PDF) |
| 184 | Transcriptional Associations of Osteoarthritis‐Mediated Loss of Epigenetic Control in Articular Cartilage | 6.1 | 59 | Citations (PDF) |
| 185 | Visceral adipose tissue is associated with microstructural brain tissue damage | 4.0 | 32 | Citations (PDF) |
| 186 | Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C | 5.5 | 9 | Citations (PDF) |
| 187 | Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER | 2.3 | 75 | Citations (PDF) |
| 188 | The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study | 3.2 | 405 | Citations (PDF) |
| 189 | Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation | 3.2 | 85 | Citations (PDF) |
| 190 | DNA Methylation Landscapes of Human Fetal Development | 3.2 | 88 | Citations (PDF) |
| 191 | Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium | 2.3 | 17 | Citations (PDF) |
| 192 | Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels | 13.7 | 217 | Citations (PDF) |
| 193 | Genetically determined prospect to become long-lived is associated with less abdominal fat and in particular less abdominal visceral fat in men | 1.8 | 10 | Citations (PDF) |
| 194 | IL7R gene expression network associates with human healthy ageing | 5.0 | 53 | Citations (PDF) |
| 195 | DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons | 5.4 | 71 | Citations (PDF) |
| 196 | New genetic loci link adipose and insulin biology to body fat distribution | 37.9 | 1,599 | Citations (PDF) |
| 197 | Genetic studies of body mass index yield new insights for obesity biology | 37.9 | 4,562 | Citations (PDF) |
| 198 | A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots | 2.3 | 134 | Citations (PDF) |
| 199 | Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age | 3.9 | 4 | Citations (PDF) |
| 200 | Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data | 1.7 | 12 | Citations (PDF) |
| 201 | Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines | 9.6 | 38 | Citations (PDF) |
| 202 | Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations | 6.5 | 141 | Citations (PDF) |
| 203 | Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis | 6.9 | 90 | Citations (PDF) |
| 204 | LDL cholesterol still a problem in old age? A Mendelian randomization study | 4.9 | 49 | Citations (PDF) |
| 205 | Characteristics of de novo structural changes in the human genome | 4.6 | 131 | Citations (PDF) |
| 206 | Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI | 3.8 | 189 | Citations (PDF) |
| 207 | Genome-wide patterns and properties of de novo mutations in humans | 25.2 | 436 | Citations (PDF) |
| 208 | Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism | 6.5 | 254 | Citations (PDF) |
| 209 | GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy | 3.4 | 289 | Citations (PDF) |
| 210 | The impact of low-frequency and rare variants on lipid levels | 25.2 | 348 | Citations (PDF) |
| 211 | MARK-AGE biomarkers of ageing | 4.7 | 227 | Citations (PDF) |
| 212 | Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship | 4.0 | 42 | Citations (PDF) |
| 213 | The transcriptional landscape of age in human peripheral blood | 13.7 | 737 | Citations (PDF) |
| 214 | Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome | 4.9 | 163 | Citations (PDF) |
| 215 | Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes | 3.0 | 9 | Citations (PDF) |
| 216 | White Matter Lesion Progression | 5.9 | 29 | Citations (PDF) |
| 217 | Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels | 13.7 | 51 | Citations (PDF) |
| 218 | A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis | 6.9 | 59 | Citations (PDF) |
| 219 | CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis | 6.9 | 39 | Citations (PDF) |
| 220 | Systematic discovery of complex insertions and deletions in human cancers | 33.0 | 105 | Citations (PDF) |
| 221 | An In Vivo Study on Brain Microstructure in Biological and Chronological Ageing | 2.3 | 2 | Citations (PDF) |
| 222 | Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study | 2.3 | 167 | Citations (PDF) |
| 223 | No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects | 2.3 | 9 | Citations (PDF) |
| 224 | Epigenetic Variation in Monozygotic Twins: A Genome-Wide Analysis of DNA Methylation in Buccal Cells | 2.5 | 53 | Citations (PDF) |
| 225 | Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance | 3.8 | 22 | Citations (PDF) |
| 226 | DNA methylation signatures link prenatal famine exposure to growth and metabolism | 13.7 | 581 | Citations (PDF) |
| 227 | A Common Mineralocorticoid Receptor Polymorphism (I180V) Interacts with Life Events in Relation to Perfectionism in Eating Disorders: A Pilot Study | 3.5 | 4 | Citations (PDF) |
| 228 | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins | 13.7 | 255 | Citations (PDF) |
| 229 | A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus | 3.8 | 38 | Citations (PDF) |
| 230 | Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial
STXBP5
and
STX2 | 6.0 | 47 | Citations (PDF) |
| 231 | Assessment of Osteoarthritis Candidate Genes in a Meta‐Analysis of Nine Genome‐Wide Association Studies | 6.1 | 119 | Citations (PDF) |
| 232 | A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip | 6.9 | 116 | Citations (PDF) |
| 233 | Genes expressed in blood link osteoarthritis with apoptotic pathways | 6.9 | 70 | Citations (PDF) |
| 234 | Meta‐analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging | 6.8 | 46 | Citations (PDF) |
| 235 | Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers | 4.9 | 99 | Citations (PDF) |
| 236 | Microstructural Brain Tissue Damage in Metabolic Syndrome | 6.2 | 57 | Citations (PDF) |
| 237 | Associations between age and gray matter volume in anatomical brain networks in middle‐aged to older adults | 6.8 | 146 | Citations (PDF) |
| 238 | Renal function in familial longevity: the Leiden Longevity Study | 3.7 | 6 | Citations (PDF) |
| 239 | A metabolomic profile is associated with the risk of incident coronary heart disease | 2.9 | 81 | Citations (PDF) |
| 240 | Variants of the IL‐10 gene associate with muscle strength in elderly from rural Africa: a candidate gene study | 6.8 | 10 | Citations (PDF) |
| 241 | Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants | 5.3 | 28 | Citations (PDF) |
| 242 | MethylAid: visual and interactive quality control of large Illumina 450k datasets | 4.7 | 193 | Citations (PDF) |
| 243 | Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age | 2.9 | 264 | Citations (PDF) |
| 244 | Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study | 3.0 | 3 | Citations (PDF) |
| 245 | Defining the role of common variation in the genomic and biological architecture of adult human height | 25.2 | 1,987 | Citations (PDF) |
| 246 | Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis | 6.9 | 21 | Citations (PDF) |
| 247 | Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31 | 25.2 | 157 | Citations (PDF) |
| 248 | In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study | 1.5 | 12 | Citations (PDF) |
| 249 | Association of Liver Enzymes and Computed Tomography Markers of Liver Steatosis with Familial Longevity | 2.3 | 9 | Citations (PDF) |
| 250 | Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children | 2.2 | 107 | Citations (PDF) |
| 251 | Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges | 2.1 | 89 | Citations (PDF) |
| 252 | The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis | 4.1 | 38 | Citations (PDF) |
| 253 | Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study | 3.3 | 187 | Citations (PDF) |
| 254 | Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array | 3.2 | 215 | Citations (PDF) |
| 255 | De Leiden Lang Leven Studie: weerspiegelt het brein een lang leven? | 0.0 | 0 | Citations (PDF) |
| 256 | Gene expression analysis of mTOR pathway: association with human longevity | 6.8 | 119 | Citations (PDF) |
| 257 | Identification of seven loci affecting mean telomere length and their association with disease | 25.2 | 916 | Citations (PDF) |
| 258 | Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect | 3.0 | 443 | Citations (PDF) |
| 259 | N-glycomic biomarkers of biological aging and longevity: A link with inflammaging | 11.6 | 218 | Citations (PDF) |
| 260 | The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway | 4.2 | 109 | Citations (PDF) |
| 261 | Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity | 5.9 | 26 | Citations (PDF) |
| 262 | The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males | 6.9 | 56 | Citations (PDF) |
| 263 | Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers | 3.2 | 367 | Citations (PDF) |
| 264 | A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function | 3.2 | 218 | Citations (PDF) |
| 265 | Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency | 3.2 | 77 | Citations (PDF) |
| 266 | Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence | 3.0 | 27 | Citations (PDF) |
| 267 | PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population | 3.6 | 59 | Citations (PDF) |
| 268 | Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles | 6.9 | 13 | Citations (PDF) |
| 269 | Facial Appearance Reflects Human Familial Longevity and Cardiovascular Disease Risk in Healthy Individuals | 3.4 | 61 | Citations (PDF) |
| 270 | Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region | 6.9 | 121 | Citations (PDF) |
| 271 | Pro‐inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength | 6.8 | 25 | Citations (PDF) |
| 272 | Ambulant 24‐h glucose rhythms mark calendar and biological age in apparently healthy individuals | 6.8 | 29 | Citations (PDF) |
| 273 | Preserved white matter integrity is a marker of familial longevity | 6.6 | 5 | Citations (PDF) |
| 274 | The influence of clan structure on the genetic variation in a single Ghanaian village | 3.0 | 20 | Citations (PDF) |
| 275 | Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects | 6.9 | 136 | Citations (PDF) |
| 276 | Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data | 2.3 | 18 | Citations (PDF) |
| 277 | Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study | 2.3 | 25 | Citations (PDF) |
| 278 | Targeted Biomarker Discovery by High Throughput Glycosylation Profiling of Human Plasma Alpha1-Antitrypsin and Immunoglobulin A | 2.3 | 47 | Citations (PDF) |
| 279 | The Genome of the Netherlands: design, and project goals | 3.0 | 266 | Citations (PDF) |
| 280 | Pathway Analysis Using Genome-Wide Association Study Data for Coronary Restenosis – A Potential Role for the PARVB Gene | 2.3 | 12 | Citations (PDF) |
| 281 | PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data | 4.7 | 26 | Citations (PDF) |
| 282 | Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals | 3.2 | 458 | Citations (PDF) |
| 283 | Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues | 6.9 | 59 | Citations (PDF) |
| 284 | Anorexia nervosa and the Val158Met polymorphism of the COMT gene | 1.3 | 30 | Citations (PDF) |
| 285 | Literature-Based Genetic Risk Scores for Coronary Heart Disease | 3.8 | 55 | Citations (PDF) |
| 286 | Chronic Inhibition of the Respiratory Chain in Human Fibroblast Cultures: Differential Responses Related to Subject Chronological and Biological Age | 3.4 | 8 | Citations (PDF) |
| 287 | Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity StudyCmaj, 2012, 184, E963-E968 | 1.2 | 12 | Citations (PDF) |
| 288 | Brain tissue volumes in familial longevity: the Leiden Longevity Study | 6.8 | 14 | Citations (PDF) |
| 289 | Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study | 62.1 | 412 | Citations (PDF) |
| 290 | Cortisol serum levels in familial longevity and perceived age: The Leiden Longevity Study | 2.7 | 18 | Citations (PDF) |
| 291 | Human
in vivo
longevity is reflected
in vitro
by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants | 3.1 | 5 | Citations (PDF) |
| 292 | Distinguishing Between Longevity and Buffered-Deleterious Genotypes for Exceptional Human Longevity: The Case of the MTP Gene | 3.4 | 28 | Citations (PDF) |
| 293 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | 25.2 | 1,209 | Citations (PDF) |
| 294 | Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs | 6.8 | 309 | Citations (PDF) |
| 295 | The number of p16INK4a positive cells in human skin reflects biological age | 6.8 | 250 | Citations (PDF) |
| 296 | The continuing value of twin studies in the omics era | 46.9 | 349 | Citations (PDF) |
| 297 | Familial Longevity Is Marked by Lower Diurnal Salivary Cortisol Levels: The Leiden Longevity Study | 2.3 | 31 | Citations (PDF) |
| 298 | Prenatal Famine and Genetic Variation Are Independently and Additively Associated with DNA Methylation at Regulatory Loci within IGF2/H19 | 2.3 | 142 | Citations (PDF) |
| 299 | Markers of Endogenous Desaturase Activity and Risk of Coronary Heart Disease in the CAREMA Cohort Study | 2.3 | 48 | Citations (PDF) |
| 300 | Pharmacogenetics of Statins: Achievements, Whole-genome Analyses and Future Perspectives | 1.5 | 39 | Citations (PDF) |
| 301 | Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes | 3.0 | 33 | Citations (PDF) |
| 302 | The place of genetics in ageing research | 46.9 | 47 | Citations (PDF) |
| 303 | Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies | 3.7 | 71 | Citations (PDF) |
| 304 | Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people | 3.0 | 95 | Citations (PDF) |
| 305 | Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity | 3.0 | 90 | Citations (PDF) |
| 306 | Genetic Variation at the TPH2 Gene Influences Impulsivity in Addition to Eating Disorders | 1.3 | 10 | Citations (PDF) |
| 307 | Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R | 2.3 | 42 | Citations (PDF) |
| 308 | Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp | 2.3 | 43 | Citations (PDF) |
| 309 | Genome-Wide Study of Gene Variants Associated with Differential Cardiovascular Event Reduction by Pravastatin Therapy | 2.3 | 33 | Citations (PDF) |
| 310 | Systematic Testing of Literature Reported Genetic Variation Associated with Coronary Restenosis: Results of the GENDER Study | 2.3 | 23 | Citations (PDF) |
| 311 | Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility | 6.9 | 55 | Citations (PDF) |
| 312 | Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health | 3.4 | 98 | Citations (PDF) |
| 313 | Variation in the CBP gene involved in epigenetic control associates with cognitive function | 3.4 | 6 | Citations (PDF) |
| 314 | Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 | 6.9 | 135 | Citations (PDF) |
| 315 | Homocysteine and Familial Longevity: The Leiden Longevity Study | 2.3 | 10 | Citations (PDF) |
| 316 | Integrating Protein-Protein Interaction Networks with Gene- Gene Co-Expression Networks improves Gene Signatures for Classifying Breast Cancer Metastasis | 1.3 | 11 | Citations (PDF) |
| 317 | DNA methylation ofIGF2,GNASAS,INSIGFandLEPand being born small for gestational age | 3.0 | 130 | Citations (PDF) |
| 318 | Familial longevity is marked by enhanced insulin sensitivity | 6.8 | 119 | Citations (PDF) |
| 319 | Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited | 6.8 | 280 | Citations (PDF) |
| 320 | Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population | 5.3 | 578 | Citations (PDF) |
| 321 | C-reactive protein and glucose regulation in familial longevity | 3.0 | 13 | Citations (PDF) |
| 322 | Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) | 3.2 | 18 | Citations (PDF) |
| 323 | Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses | 1.8 | 36 | Citations (PDF) |
| 324 | Abdominal Fat Accumulation in Adults Born Preterm Exposed Antenatally to Maternal Glucocorticoid Treatment Is Dependent on Glucocorticoid Receptor Gene Variation | 4.0 | 17 | Citations (PDF) |
| 325 | Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans | 3.3 | 184 | Citations (PDF) |
| 326 | A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention | 2.9 | 14 | Citations (PDF) |
| 327 | Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies | 3.9 | 19 | Citations (PDF) |
| 328 | Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis | 6.9 | 134 | Citations (PDF) |
| 329 | Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults | 18.0 | 69 | Citations (PDF) |
| 330 | Handgrip strength at midlife and familial longevity | 3.0 | 20 | Citations (PDF) |
| 331 | Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study | 3.0 | 23 | Citations (PDF) |
| 332 | Parental longevity correlates with offspring’s optimism in two cohorts of community-dwelling older subjects | 3.0 | 10 | Citations (PDF) |
| 333 | C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects | 4.8 | 7 | Citations (PDF) |
| 334 | High serum glucose levels are associated with a higher perceived age | 3.0 | 53 | Citations (PDF) |
| 335 | Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways | 3.0 | 119 | Citations (PDF) |
| 336 | Association between Several Clinical and Radiological Determinants with Long-Term Clinical Progression and Good Prognosis of Lower Limb Osteoarthritis | 2.3 | 24 | Citations (PDF) |
| 337 | Interleukin-1 region meta-analysis with osteoarthritis phenotypes | 5.5 | 31 | Citations (PDF) |
| 338 | Interleukin‐1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study | 6.1 | 10 | Citations (PDF) |
| 339 | Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study | 2.9 | 78 | Citations (PDF) |
| 340 | A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-α levels | 3.0 | 24 | Citations (PDF) |
| 341 | Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity | 2.3 | 117 | Citations (PDF) |
| 342 | Low Serum Free Triiodothyronine Levels Mark Familial Longevity: The Leiden Longevity Study | 3.4 | 64 | Citations (PDF) |
| 343 | Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity | 7.5 | 150 | Citations (PDF) |
| 344 | Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function | 4.2 | 137 | Citations (PDF) |
| 345 | Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps | 4.2 | 52 | Citations (PDF) |
| 346 | Genetic Variation in Pentraxin (PTX) 3 Gene Associates with PTX3 Production and Fertility in Women1 | 2.5 | 35 | Citations (PDF) |
| 347 | Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology | 0.6 | 297 | Citations (PDF) |
| 348 | A Meta-analysis of Four Genome-Wide Association Studies of Survival to Age 90 Years or Older: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium | 3.4 | 126 | Citations (PDF) |
| 349 | No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis | 11.6 | 27 | Citations (PDF) |
| 350 | Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study | 1.5 | 44 | Citations (PDF) |
| 351 | Influence of Candidate Genes on Attention Problems in Children: A Longitudinal Study | 1.3 | 12 | Citations (PDF) |
| 352 | Lipid metabolism in long-lived families: the Leiden Longevity Study | 3.0 | 87 | Citations (PDF) |
| 353 | Selection for Genetic Variation Inducing Pro-Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population | 2.3 | 41 | Citations (PDF) |
| 354 | Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child | 2.3 | 427 | Citations (PDF) |
| 355 | Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression | 1.5 | 25 | Citations (PDF) |
| 356 | Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis | 6.1 | 47 | Citations (PDF) |
| 357 | Large‐scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand | 6.1 | 193 | Citations (PDF) |
| 358 | Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study | 3.0 | 15 | Citations (PDF) |
| 359 | Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study | 2.9 | 275 | Citations (PDF) |
| 360 | Genome-wide Association Study of Smoking Initiation and Current Smoking | 6.5 | 134 | Citations (PDF) |
| 361 | DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific | 2.9 | 1,119 | Citations (PDF) |
| 362 | VDR gene variants associate with cognitive function and depressive symptoms in old age | 3.4 | 132 | Citations (PDF) |
| 363 | Common CFTR gene variants influence body composition and survival in rural Ghana | 2.9 | 3 | Citations (PDF) |
| 364 | Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana | 3.0 | 22 | Citations (PDF) |
| 365 | Hematopoietic Capacity and Exceptional Survival: The Leiden Longevity Study | 2.9 | 3 | Citations (PDF) |
| 366 | Genes encoding longevity: from model organisms to humans | 6.8 | 111 | Citations (PDF) |
| 367 | Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study | 3.7 | 9 | Citations (PDF) |
| 368 | Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis | 2.9 | 197 | Citations (PDF) |
| 369 | Genetic variation in the interleukin-1 -converting enzyme associates with cognitive function. The PROSPER studyBrain, 2008, 131, 1069-1077 | 8.4 | 69 | Citations (PDF) |
| 370 | A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility | 2.9 | 165 | Citations (PDF) |
| 371 | Persistent epigenetic differences associated with prenatal exposure to famine in humans | 7.5 | 2,933 | Citations (PDF) |
| 372 | New insights into osteoarthritis: early developmental features of an ageing-related disease | 3.6 | 68 | Citations (PDF) |
| 373 | Genome-Wide Linkage Analysis of Multiple Measures of Neuroticism of 2 Large Cohorts From Australia and the Netherlands | 12.7 | 36 | Citations (PDF) |
| 374 | Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus | 2.9 | 221 | Citations (PDF) |
| 375 | Polymorphisms in Proinflammatory Genes and Susceptibility to Typhoid Fever and Paratyphoid Fever | 1.7 | 15 | Citations (PDF) |
| 376 | The 23K Variant of the R23K Polymorphism in the Glucocorticoid Receptor Gene Protects against Postnatal Growth Failure and Insulin Resistance after Preterm Birth | 4.0 | 30 | Citations (PDF) |
| 377 | Liver X Receptor Alpha Associates With Human Life Span | 3.4 | 21 | Citations (PDF) |
| 378 | SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study | 3.4 | 78 | Citations (PDF) |
| 379 | Genetic Association Analysis of RHOB and TXNDC3 in Osteoarthritis | 6.5 | 15 | Citations (PDF) |
| 380 | Amino acid profiling in urine by capillary zone electrophoresis – mass spectrometry | 3.7 | 58 | Citations (PDF) |
| 381 | Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age | 3.0 | 104 | Citations (PDF) |
| 382 | Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis | 3.0 | 22 | Citations (PDF) |
| 383 | Telomere length predicts survival independent of genetic influences | 6.8 | 282 | Citations (PDF) |
| 384 | Genetic Variation in the Interleukin-10 Gene Promoter and Risk of Coronary and Cerebrovascular Events: The PROSPER Study | 4.0 | 43 | Citations (PDF) |
| 385 | Family Based Association Analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression | 1.3 | 83 | Citations (PDF) |
| 386 | Chromosome 4q25, Microsomal Transfer Protein Gene, and Human Longevity: Novel Data and a Meta-Analysis of Association Studies | 3.4 | 68 | Citations (PDF) |
| 387 | Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes | 3.0 | 28 | Citations (PDF) |
| 388 | Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study | 3.5 | 41 | Citations (PDF) |
| 389 | Impact of genetic variations in the WRN gene on age related pathologies and mortality | 4.7 | 22 | Citations (PDF) |
| 390 | Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes | 6.1 | 199 | Citations (PDF) |
| 391 | Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity | 8.0 | 54 | Citations (PDF) |
| 392 | Butyrylcholinesterase: Association with the Metabolic Syndrome and Identification of 2 Gene Loci Affecting Activity | 1.1 | 59 | Citations (PDF) |
| 393 | Mental Performance in Old Age Dependent on Cortisol and Genetic Variance in the Mineralocorticoid and Glucocorticoid Receptors | 5.4 | 123 | Citations (PDF) |
| 394 | ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age | 8.0 | 118 | Citations (PDF) |
| 395 | Reduced insulin/IGF‐1 signalling and human longevity | 6.8 | 303 | Citations (PDF) |
| 396 | Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions | 3.0 | 46 | Citations (PDF) |
| 397 | Variation in the human TP53 gene affects old age survival and cancer mortality | 3.7 | 204 | Citations (PDF) |
| 398 | What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? | 4.7 | 113 | Citations (PDF) |
| 399 | Shuttling between species for pathways of lifespan regulation: A central role for the vitellogenin gene family? | 2.1 | 41 | Citations (PDF) |
| 400 | Reply | 6.1 | 10 | Citations (PDF) |
| 401 | Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study | 3.0 | 384 | Citations (PDF) |
| 402 | Genetic Linkage and Association Analysis for Loneliness in Dutch Twin and Sibling Pairs Points to a Region on Chromosome 12q23–24 | 1.3 | 39 | Citations (PDF) |
| 403 | Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression | 1.3 | 8 | Citations (PDF) |
| 404 | Replicated Linkage for Eye Color on 15q Using Comparative Ratings of Sibling Pairs | 1.3 | 25 | Citations (PDF) |
| 405 | Genome-wide Linkage Scan to Identify Loci for Age at First Cigarette in Dutch Sibling Pairs | 1.3 | 27 | Citations (PDF) |
| 406 | QTLs for height: results of a full genome scan in Dutch sibling pairs | 3.0 | 28 | Citations (PDF) |
| 407 | Variation in the SHC1 gene and longevity in humans | 3.7 | 25 | Citations (PDF) |
| 408 | Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip | 6.1 | 101 | Citations (PDF) |
| 409 | Combined association and linkage analysis applied to theAPOE locus | 3.1 | 15 | Citations (PDF) |
| 410 | Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population | 3.0 | 31 | Citations (PDF) |
| 411 | Association of APOE ε2/ε3/ε4 and promoter gene variants with dementia but not cardiovascular mortality in old age | 0.5 | 47 | Citations (PDF) |
| 412 | Detection of sequence variability of the collagen type IIα 1 3′ variable number of tandem repeat | 2.6 | 3 | Citations (PDF) |
| 413 | Genetics of Human Aging: The Search for Genes Contributing to Human Longevity and Diseases of the Old | 4.0 | 32 | Citations (PDF) |
| 414 | Mortality risk in men is associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR) | 3.0 | 49 | Citations (PDF) |
| 415 | Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine | 6.1 | 132 | Citations (PDF) |
| 416 | Genetica: een panacee? – II | 0.0 | 1 | Citations (PDF) |
| 417 | Genetics and Behavioral Medicine: Risk Factors for Cardiovascular Disease | 2.4 | 14 | Citations (PDF) |
| 418 | Genetica: een panacee? – I | 0.0 | 0 | Citations (PDF) |
| 419 | Reduced Response to Activated Protein C Is Associated with Increased Risk for Cerebrovascular Disease | 9.6 | 108 | Citations (PDF) |
| 420 | The Dynamics of Genome Organization and Expression during the Aging Process | 4.0 | 10 | Citations (PDF) |
| 421 | DNA Processing, Aging, and Cancer. | 4.0 | 0 | Citations (PDF) |
| 422 | TheCaenorhabditis elegunsgenome contains monomorphic minisatellites and simple sequences | 15.5 | 23 | Citations (PDF) |
| 423 | Genetic instability and aging: theories, facts, and future perspectives | 2.0 | 50 | Citations (PDF) |
| 424 | DNA methods for detecting and analyzing mutations in vivo | 1.8 | 17 | Citations (PDF) |
| 425 | Sequence heterogeneity within the human alphoid repetitive DNA family | 15.5 | 86 | Citations (PDF) |
| 426 | Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population | 0.7 | 193 | Citations (PDF) |
| 427 | Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants | 4.6 | 3 | Citations (PDF) |
| 428 | Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport | 5.0 | 4 | Citations (PDF) |
| 429 | Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus | 13.7 | 6 | Citations (PDF) |
| 430 | Absolute quantification of polar metabolites using matrix-free calibration curves and post-column infusion of standards in HILIC-MS based metabolomics | 3.7 | 2 | Citations (PDF) |
| 431 | Effects of a Combined Dietary and Physical Activity Intervention on Bone Density, Lean Mass and Fat Mass in Adults: The GOTO Trial | 9.1 | 0 | Citations (PDF) |
| 432 | ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline | 3.2 | 0 | Citations (PDF) |
| 433 | Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging | 4.6 | 1 | Citations (PDF) |
