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75 PR articles • 5,513 PR citations • Sorted by year • Download PDF (PDF by citations)
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1Mammalian DNA ligases; roles in maintaining genome integrity
Journal of Molecular Biology, 2024, 436, 168276
4.218Citations (PDF)
2FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease13.929Citations (PDF)
3Redundant but essential functions of PARP1 and PARP2 in DNA ligase I-independent DNA replication
Nucleic Acids Research, 2024, 52, 10341-10354
15.84Citations (PDF)
4The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions
Nucleic Acids Research, 2023, 51, 7342-7356
15.820Citations (PDF)
5Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase
Structure, 2022, 30, 371-385.e5
3.912Citations (PDF)
6Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers
Theranostics, 2021, 11, 8350-8361
11.522Citations (PDF)
7Structural basis of long-range to short-range synaptic transition in NHEJ
Nature, 2021, 593, 294-298
39.5143Citations (PDF)
8Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus2.312Citations (PDF)
9An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex
Nucleic Acids Research, 2021, 49, 306-321
15.831Citations (PDF)
10Altered DNA ligase activity in human disease
Mutagenesis, 2020, 35, 51-60
5.332Citations (PDF)
11Human DNA ligases in replication and repair
DNA Repair, 2020, 93, 102908
2.648Citations (PDF)
12XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
NAR Cancer, 2020, 2,
2.948Citations (PDF)
13Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation
Journal of Molecular Biology, 2020, 432, 166698
4.220Citations (PDF)
14NAD+ is not utilized as a co-factor for DNA ligation by human DNA ligase IV
Nucleic Acids Research, 2020, 48, 12746-12750
15.84Citations (PDF)
151HN, 13C, and 15N backbone resonance assignments of the human DNA ligase 3 DNA-binding domain (residues 257-477)
Biomolecular NMR Assignments, 2019, 13, 305-308
0.72Citations (PDF)
16Repair of DNA double-strand breaks by mammalian alternative end-joining pathways
Journal of Biological Chemistry, 2018, 293, 10536-10546
2.3205Citations (PDF)
17Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis13.9191Citations (PDF)
18The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast
Nucleic Acids Research, 2017, 45, 5887-5900
15.834Citations (PDF)
19The Human Ligase IIIα-XRCC1 Protein Complex Performs DNA Nick Repair after Transient Unwrapping of Nucleosomal DNA
Journal of Biological Chemistry, 2017, 292, 5227-5238
2.338Citations (PDF)
20Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor
DNA Repair, 2017, 60, 29-39
2.623Citations (PDF)
21SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV
DNA Repair, 2016, 43, 18-23
2.664Citations (PDF)
22Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex
Journal of Biological Chemistry, 2016, 291, 21893-21902
2.329Citations (PDF)
23Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1–Dependent Apoptosis in Cancer Cells
Cancer Research, 2016, 76, 5431-5441
0.624Citations (PDF)
24An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex
Journal of Biological Chemistry, 2016, 291, 26987-27006
2.370Citations (PDF)
25Synthesis and structure determination of SCR7, a DNA ligase inhibitor
Tetrahedron Letters, 2016, 57, 3204-3207
1.36Citations (PDF)
26Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks
DNA Repair, 2016, 42, 107-118
2.626Citations (PDF)
27Aromatase Inhibitor–Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer
Molecular Cancer Therapeutics, 2015, 14, 1728-1737
1.817Citations (PDF)
28Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining
Nucleic Acids Research, 2015, 43, 7021-7031
15.828Citations (PDF)
29The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome
Journal of Biological Chemistry, 2015, 290, 20919-20933
2.347Citations (PDF)
30Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining
DNA Repair, 2015, 31, 1-10
2.616Citations (PDF)
31Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells
Oncoscience, 2015, 2, 272-284
1.32Citations (PDF)
32Ubiquitin-specific Peptidase 20 Regulates Rad17 Stability, Checkpoint Kinase 1 Phosphorylation and DNA Repair by Homologous Recombination
Journal of Biological Chemistry, 2014, 289, 22739-22748
2.331Citations (PDF)
33Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Molecular Cell, 2014, 55, 829-842
13.7312Citations (PDF)
34Structure and function of the DNA ligases encoded by the mammalian LIG3 gene
Gene, 2013, 531, 150-157
2.458Citations (PDF)
35Phosphorylation of Serine 51 Regulates the Interaction of Human DNA Ligase I with Replication Factor C and Its Participation in DNA Replication and Repair
Journal of Biological Chemistry, 2012, 287, 36711-36719
2.315Citations (PDF)
36The Interaction between Polynucleotide Kinase Phosphatase and the DNA Repair Protein XRCC1 Is Critical for Repair of DNA Alkylation Damage and Stable Association at DNA Damage Sites
Journal of Biological Chemistry, 2012, 287, 39233-39244
2.331Citations (PDF)
37Targeting Abnormal DNA Repair in Therapy-Resistant Breast Cancers
Molecular Cancer Research, 2012, 10, 96-107
3.587Citations (PDF)
38A High-Throughput Scintillation Proximity-Based Assay for Human DNA Ligase IV1.515Citations (PDF)
39The Nucleotide Sequence, DNA Damage Location, and Protein Stoichiometry Influence the Base Excision Repair Outcome at CAG/CTG Repeats
Biochemistry, 2012, 51, 3919-3932
2.839Citations (PDF)
40Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway
Journal of Biological Chemistry, 2011, 286, 33845-33853
2.3130Citations (PDF)
41Yeast Nej1 Is a Key Participant in the Initial End Binding and Final Ligation Steps of Nonhomologous End Joining
Journal of Biological Chemistry, 2011, 286, 4931-4940
2.344Citations (PDF)
42Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States
Biochemistry, 2010, 49, 6165-6176
2.8100Citations (PDF)
43Phosphorylation of Human DNA Ligase I Regulates Its Interaction with Replication Factor C and Its Participation in DNA Replication and DNA Repair
Molecular and Cellular Biology, 2009, 29, 2042-2052
2.529Citations (PDF)
44CTG/CAG Repeat Instability Is Modulated by the Levels of Human DNA Ligase I and Its Interaction with Proliferating Cell Nuclear Antigen
Journal of Biological Chemistry, 2009, 284, 26631-26645
2.337Citations (PDF)
45The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1
DNA Repair, 2009, 8, 912-919
2.626Citations (PDF)
46Distinct kinetics of human DNA ligases I, IIIα, IIIβ, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair
DNA Repair, 2009, 8, 961-968
2.628Citations (PDF)
47Eukaryotic DNA Ligases: Structural and Functional Insights17.8314Citations (PDF)
48Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design
Journal of Medicinal Chemistry, 2008, 51, 4553-4562
6.778Citations (PDF)
49Two DNA-binding and Nick Recognition Modules in Human DNA Ligase III
Journal of Biological Chemistry, 2008, 283, 10764-10772
2.355Citations (PDF)
50Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair
Cancer Research, 2008, 68, 3169-3177
0.6165Citations (PDF)
51Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks
Blood, 2008, 112, 1413-1423
4.2142Citations (PDF)
52A Conserved Physical and Functional Interaction between the Cell Cycle Checkpoint Clamp Loader and DNA Ligase I of Eukaryotes
Journal of Biological Chemistry, 2007, 282, 22721-22730
2.320Citations (PDF)
53Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination8.7121Citations (PDF)
54NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells
DNA Repair, 2006, 5, 1439-1448
2.6135Citations (PDF)
55A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA
Molecular Cell, 2006, 24, 279-291
13.7149Citations (PDF)
56Genetic Instability Induced by Overexpression of DNA Ligase I in Budding Yeast
Genetics, 2005, 171, 427-441
4.237Citations (PDF)
57Translocation of XRCC1 and DNA ligase III  from centrosomes to chromosomes in response to DNA damage in mitotic human cells
Nucleic Acids Research, 2005, 33, 422-429
15.851Citations (PDF)
58Mechanism of DNA double-strand break repair by non-homologous end joining
DNA Repair, 2005, 4, 639-648
2.6272Citations (PDF)
59Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line
DNA Repair, 2005, 4, 649-654
2.630Citations (PDF)
60Processing and Joining of DNA Ends Coordinated by Interactions among Dnl4/Lif1, Pol4, and FEN-1
Journal of Biological Chemistry, 2004, 279, 47580-47588
2.349Citations (PDF)
61XRCC1 co-localizes and physically interacts with PCNA
Nucleic Acids Research, 2004, 32, 2193-2201
15.8179Citations (PDF)
62A Conserved Interaction between the Replicative Clamp Loader and DNA Ligase in Eukaryotes
Journal of Biological Chemistry, 2004, 279, 55196-55201
2.353Citations (PDF)
63Physical and Functional Interaction between the XPF/ERCC1 Endonuclease and hRad52
Journal of Biological Chemistry, 2004, 279, 13634-13639
2.392Citations (PDF)
64Human DNA ligase I completely encircles and partially unwinds nicked DNA
Nature, 2004, 432, 473-478
39.5323Citations (PDF)
65AP Endonuclease-Independent DNA Base Excision Repair in Human Cells
Molecular Cell, 2004, 15, 209-220
13.7457Citations (PDF)
66Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair
Molecular and Cellular Biology, 2003, 23, 5919-5927
2.5220Citations (PDF)
67A Physical and Functional Interaction between Yeast Pol4 and Dnl4-Lif1 Links DNA Synthesis and Ligation in Nonhomologous End Joining
Journal of Biological Chemistry, 2002, 277, 45630-45637
2.3101Citations (PDF)
68Promotion of Dnl4-Catalyzed DNA End-Joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 Complexes
Molecular Cell, 2001, 8, 1105-1115
13.7281Citations (PDF)
69Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair
Current Biology, 2000, 10, 919-S2
3.7230Citations (PDF)
70Interactions of the DNA Ligase IV-XRCC4 Complex with DNA Ends and the DNA-dependent Protein Kinase
Journal of Biological Chemistry, 2000, 275, 26196-26205
2.3195Citations (PDF)
71DNA Ligase III Is Recruited to DNA Strand Breaks by a Zinc Finger Motif Homologous to That of Poly(ADP-ribose) Polymerase
Journal of Biological Chemistry, 1999, 274, 21679-21687
2.395Citations (PDF)
72Thermodynamics of Human DNA Ligase I Trimerization and Association with DNA Polymerase β
Journal of Biological Chemistry, 1998, 273, 20540-20550
2.372Citations (PDF)
73Specific Interaction of DNA Polymerase β and DNA Ligase I in a Multiprotein Base Excision Repair Complex from Bovine Testis
Journal of Biological Chemistry, 1996, 271, 16000-16007
2.3245Citations (PDF)
74Purification and Characterization of DNA Ligase III from Bovine Testes
Journal of Biological Chemistry, 1995, 270, 9683-9690
2.369Citations (PDF)
75Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents
Cell, 1992, 69, 495-503
34.4279Citations (PDF)