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109 papers • 32,021 citations • Sorted by year • Download PDF (PDF by citations)
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1Liver Metastasis Modulate Responses of Suppressive Macrophages and Exhausted T Cells to Immunotherapy Revealed by Single Cell Sequencing2.16Citations (PDF)
2STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets8.132Citations (PDF)
3Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials
Immunity, 2020, 52, 36-54
16.7163Citations (PDF)
4Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis
Journal of Leukocyte Biology, 2020, 107, 917-932
3.026Citations (PDF)
5Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer
Cell, 2020, 181, 442-459.e29
28.61,268Citations (PDF)
6LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody–Induced Tumor Cell Killing by Effector CD8+ T Cells
Journal of Immunology, 2019, 203, 1076-1087
0.645Citations (PDF)
7The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Nature, 2019, 575, 217-223
34.31,946Citations (PDF)
8Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
European Journal of Immunology, 2019, 49, 1457-1973
3.4917Citations (PDF)
9IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Immunity, 2019, 50, 871-891
16.7931Citations (PDF)
10Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis3.511Citations (PDF)
11Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes
Journal of Immunology, 2019, 202, 1935-1941
0.633Citations (PDF)
12Targeting IL-10 Family Cytokines for the Treatment of Human Diseases7.4256Citations (PDF)
13Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases
Biochemical Pharmacology, 2018, 152, 224-235
5.255Citations (PDF)
14Nonclinical safety assessment of a human interleukin‐22<scp>FC IG</scp> fusion protein demonstrates in vitro to in vivo and cross‐species translatability2.313Citations (PDF)
15Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
Nature, 2018, 564, 268-272
34.31,197Citations (PDF)
16TRIMming TGF-β signals in Th17 cells
Journal of Experimental Medicine, 2018, 215, 1775-1776
8.13Citations (PDF)
17Inflammatory Bowel Disease Susceptibility Gene <i>C1ORF106</i> Regulates Intestinal Epithelial Permeability
ImmunoHorizons, 2018, 2, 164-171
1.715Citations (PDF)
18Mice deficient in NRROS show abnormal microglial development and neurological disorders
Nature Immunology, 2017, 18, 633-641
24.966Citations (PDF)
19Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
Cell, 2017, 169, 1342-1356.e16
28.61,943Citations (PDF)
20IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis
Journal of Immunology, 2017, 199, 3849-3857
0.661Citations (PDF)
21Guidelines for the use of flow cytometry and cell sorting in immunological studies<sup>*</sup>
European Journal of Immunology, 2017, 47, 1584-1797
3.4564Citations (PDF)
22Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB
EBioMedicine, 2017, 25, 20-21
9.04Citations (PDF)
23IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice
PLoS ONE, 2017, 12, e0170639
2.596Citations (PDF)
24Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome
Journal of Immunology, 2016, 197, 97-107
0.6130Citations (PDF)
25Regulation of Interleukin-10 Expression8.0133Citations (PDF)
26Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases10.671Citations (PDF)
27The Itch to degrade ROR-γt
Nature Immunology, 2016, 17, 898-900
24.96Citations (PDF)
28Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22
International Immunology, 2016, 28, 233-243
3.532Citations (PDF)
29The IL-20 Subfamily of Cytokines and Their Receptors
2016, , 554-562
0Citations (PDF)
30TRAF4-SMURF2–Mediated DAZAP2 Degradation Is Critical for IL-25 Signaling and Allergic Airway Inflammation
Journal of Immunology, 2015, 194, 2826-2837
0.634Citations (PDF)
31Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists2.168Citations (PDF)
32Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection
Immunity, 2015, 42, 321-331
16.7179Citations (PDF)
33Discovery of 1-{4-[3-Fluoro-4-((3<i>S</i>,6<i>R</i>)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist
Journal of Medicinal Chemistry, 2015, 58, 5308-5322
6.961Citations (PDF)
34Deciphering the crosstalk among IL-1 and IL-10 family cytokines in intestinal immunity
Trends in Immunology, 2015, 36, 471-478
9.132Citations (PDF)
35A Novel IL-25 Signaling Pathway through STAT5
Journal of Immunology, 2015, 194, 4528-4534
0.631Citations (PDF)
36A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis
Journal of Experimental Medicine, 2015, 212, 1571-1587
8.1203Citations (PDF)
37Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action3.482Citations (PDF)
38A reversed sulfonamide series of selective RORc inverse agonists2.130Citations (PDF)
39The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
Nature Reviews Immunology, 2014, 14, 783-795
38.9352Citations (PDF)
40Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis13.745Citations (PDF)
41NRROS negatively regulates reactive oxygen species during host defence and autoimmunity
Nature, 2014, 509, 235-239
34.3234Citations (PDF)
42Th17 Cells at the Crossroads of Autoimmunity, Inflammation, and Atherosclerosis
Immunity, 2014, 40, 10-12
16.730Citations (PDF)
43Psoriasis-like skin lesions are dependent on IL-23 but develop in the absence of IL-22 in a model mouse2.69Citations (PDF)
44Homeostatic IL-23 receptor signaling limits Th17 response through IL-22–mediated containment of commensal microbiota7.597Citations (PDF)
45Role of IL-22 in Microbial Host Defense0.085Citations (PDF)
46Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
Nature, 2014, 514, 237-241
34.3446Citations (PDF)
47Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists2.147Citations (PDF)
48The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria
Immunity, 2014, 40, 262-273
16.7274Citations (PDF)
49PILRα Negatively Regulates Mouse Inflammatory Arthritis
Journal of Immunology, 2014, 193, 860-870
0.635Citations (PDF)
50Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells
Nature, 2014, 518, 417-421
34.3126Citations (PDF)
51Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells
2014, , 147-177
1Citations (PDF)
52Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
Nature Immunology, 2013, 14, 937-948
24.9435Citations (PDF)
53An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
Nature Medicine, 2013, 19, 1114-1123
36.5420Citations (PDF)
54Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc2.161Citations (PDF)
55<scp>IL</scp>‐22, not simply a Th17 cytokine
Immunological Reviews, 2013, 252, 116-132
6.8419Citations (PDF)
56Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus
Nature Immunology, 2013, 14, 804-811
24.9123Citations (PDF)
57IL-22–producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis7.5332Citations (PDF)
58Therapeutic opportunities of the IL-22–IL-22R1 system39.5528Citations (PDF)
59Dectin-1-Dependent Interleukin-22 Contributes to Early Innate Lung Defense against Aspergillus fumigatus
Infection and Immunity, 2012, 80, 410-417
2.8126Citations (PDF)
60Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
Immunity, 2012, 37, 1061-1075
16.7429Citations (PDF)
61Regulation of epithelial immunity by IL-17 family cytokines
Trends in Immunology, 2012, 33, 343-349
9.1121Citations (PDF)
62A role for Th17 cells in the regulation of tertiary lymphoid follicles
European Journal of Immunology, 2012, 42, 2255-2262
3.487Citations (PDF)
63IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination
Journal of Neuroscience, 2012, 32, 8284-8292
3.763Citations (PDF)
64IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Nature, 2012, 491, 259-263
34.3700Citations (PDF)
65IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection
Mucosal Immunology, 2012, 6, 69-82
7.0172Citations (PDF)
66The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90
Nature Immunology, 2012, 14, 72-81
24.9107Citations (PDF)
67Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells
Nature Immunology, 2011, 12, 1238-1245
24.9201Citations (PDF)
68The Roles of IL-22 and Its Related Family Members in the Pathogenesis of Psoriasis
2011, , 445-462
0Citations (PDF)
69IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
Nature Immunology, 2011, 12, 1159-1166
24.9447Citations (PDF)
70Regulation of interleukin-10 and interleukin-22 expression in T helper cells5.666Citations (PDF)
71The IL‐17 pathway as a major therapeutic target in autoimmune diseases4.6128Citations (PDF)
72Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
Annual Review of Immunology, 2011, 29, 71-109
31.11,709Citations (PDF)
73Murine Insulin Growth Factor-like (IGFL) and Human IGFL1 Proteins Are Induced in Inflammatory Skin Conditions and Bind to a Novel Tumor Necrosis Factor Receptor Family Member, IGFLR1
Journal of Biological Chemistry, 2011, 286, 18969-18981
2.346Citations (PDF)
74Impaired B cell immunity in IL-22 knock-out mice in collagen induced arthritis1.55Citations (PDF)
75IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium
Nature Immunology, 2011, 12, 941-948
24.9153Citations (PDF)
76Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice
Mucosal Immunology, 2011, 5, 99-109
7.0106Citations (PDF)
77The IL-17 Family Cytokines in Immunity and Disease3.4113Citations (PDF)
78Even Neurons Are Excited by Th17 Cells
Immunity, 2010, 33, 298-300
16.75Citations (PDF)
79Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages7.5160Citations (PDF)
80IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail
Journal of Immunology, 2010, 185, 1063-1070
0.6116Citations (PDF)
81IL-17RC Is Required for IL-17A– and IL-17F–Dependent Signaling and the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Journal of Immunology, 2010, 184, 4307-4316
0.6138Citations (PDF)
82Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease10.6107Citations (PDF)
83The Serine Protease Marapsin Is Expressed in Stratified Squamous Epithelia and Is Up-regulated in the Hyperproliferative Epidermis of Psoriasis and Regenerating Wounds2.343Citations (PDF)
84Interleukin (IL)-23 mediates <i>Toxoplasma gondii</i>–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
Journal of Experimental Medicine, 2009, 206, 3047-3059
8.1277Citations (PDF)
85STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
Journal of Experimental Medicine, 2009, 206, 1465-1472
8.1968Citations (PDF)
86Novel therapeutic targets along the Th17 pathway3.421Citations (PDF)
87Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Nature Medicine, 2008, 14, 282-289
36.51,802Citations (PDF)
88The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
Immunity, 2008, 28, 454-467
16.71,810Citations (PDF)
89IL-22 in mucosal immunity
Mucosal Immunology, 2008, 1, 335-338
7.060Citations (PDF)
90The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis
Journal of Immunology, 2007, 178, 2229-2240
0.6495Citations (PDF)
91Targeting the development and effector functions of TH17 cells
Seminars in Immunology, 2007, 19, 383-393
6.674Citations (PDF)
92Role of cytokine therapy in the treatment of psoriasis0.50Citations (PDF)
93Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Nature, 2006, 445, 648-651
34.31,777Citations (PDF)
94Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data
Genes and Immunity, 2005, 6, 319-331
3.1385Citations (PDF)
95A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator7.5242Citations (PDF)
96ERM is required for transcriptional control of the spermatogonial stem cell niche
Nature, 2005, 436, 1030-1034
34.3304Citations (PDF)
97Proteomic Profiling of Surface Proteins on Th1 and Th2 Cells3.750Citations (PDF)
98Targeting interferon-α: a promising approach for systemic lupus erythematosus therapy
Lupus, 2004, 13, 348-352
1.735Citations (PDF)
99The Function Role of GATA-3 in Th1 and Th2 Differentiation
Immunologic Research, 2003, 28, 25-38
2.9133Citations (PDF)
100IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production
Nature Immunology, 2001, 2, 157-164
24.9243Citations (PDF)
101Unexpected Characteristics of the IFN-γ Reporters in Nontransformed T Cells
Journal of Immunology, 2001, 167, 855-865
0.640Citations (PDF)
102An Instructive Component in T Helper Cell Type 2 (Th2) Development Mediated by Gata-38.1102Citations (PDF)
103Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells
Journal of Experimental Medicine, 2001, 194, 1461-1471
8.182Citations (PDF)
104Signaling and Transcription in T Helper Development
Annual Review of Immunology, 2000, 18, 451-494
31.1601Citations (PDF)
105Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment
Immunity, 2000, 12, 27-37
16.7651Citations (PDF)
106The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway7.5100Citations (PDF)
107Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation3.4192Citations (PDF)
108Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism
Immunity, 1998, 9, 745-755
16.7732Citations (PDF)
109The effects of 2ip and 2,4-D on rice calli differentiation
Plant Growth Regulation, 1996, 19, 19-24
3.78Citations (PDF)