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104 PR articles • 30,898 PR citations • Sorted by year • Download PDF (PDF by citations)
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1Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells
Cell Stem Cell, 2025, 32, 191-208.e11
16.420Citations (PDF)
2High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion
Nature Communications, 2025, 16,
13.75Citations (PDF)
3Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state
Journal of Clinical Investigation, 2023, 133,
10.611Citations (PDF)
4Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions
ELife, 2023, 12,
1.611Citations (PDF)
5CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer’s disease PSEN1 M146L mutation
Molecular Therapy - Nucleic Acids, 2022, 28, 450-461
5.543Citations (PDF)
6Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors
Cell Genomics, 2022, 2, 100119
6.89Citations (PDF)
7Engineered CRISPR prime editors with compact, untethered reverse transcriptases
Nature Biotechnology, 2022, 41, 337-343
29.881Citations (PDF)
8A Code of Ethics for Gene Drive Research
CRISPR Journal, 2021, 4, 19-24
3.538Citations (PDF)
9PrimeDesign software for rapid and simplified design of prime editing guide RNAs
Nature Communications, 2021, 12,
13.7165Citations (PDF)
10Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA
Nature Protocols, 2021, 16, 1511-1547
14.446Citations (PDF)
11Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118,
7.534Citations (PDF)
12CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells
Nature Biotechnology, 2021, 40, 189-193
29.8189Citations (PDF)
13Augmenting and directing long-range CRISPR-mediated activation in human cells
Nature Methods, 2021, 18, 1075-1081
24.629Citations (PDF)
14Defining genome-wide CRISPR–Cas genome-editing nuclease activity with GUIDE-seq
Nature Protocols, 2021, 16, 5592-5615
14.476Citations (PDF)
15Zebrafish<i>dscaml1</i>Deficiency Impairs Retinal Patterning and Oculomotor Function
Journal of Neuroscience, 2020, 40, 143-158
3.725Citations (PDF)
16Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources
2020, 8, e000990
25Citations (PDF)
17Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function
Molecular Therapy - Nucleic Acids, 2020, 21, 1-12
5.513Citations (PDF)
18A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
Nature Biotechnology, 2020, 38, 861-864
29.8228Citations (PDF)
19Therapeutic base editing of human hematopoietic stem cells
Nature Medicine, 2020, 26, 535-541
33.0269Citations (PDF)
20Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish
Scientific Reports, 2020, 10,
3.420Citations (PDF)
21Technologies and Computational Analysis Strategies for CRISPR Applications
Molecular Cell, 2020, 79, 11-29
13.341Citations (PDF)
22Optimization of AsCas12a for combinatorial genetic screens in human cells
Nature Biotechnology, 2020, 39, 94-104
29.8199Citations (PDF)
23CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
Nature Biotechnology, 2020, 39, 41-46
29.8498Citations (PDF)
24Activities and specificities of <scp>CRISPR</scp>/Cas9 and Cas12a nucleases for targeted mutagenesis in maize
Plant Biotechnology Journal, 2019, 17, 362-372
8.8237Citations (PDF)
25Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
Nature Medicine, 2019, 25, 1123-1130
33.0186Citations (PDF)
26CRISPR DNA base editors with reduced RNA off-target and self-editing activities
Nature Biotechnology, 2019, 37, 1041-1048
29.8312Citations (PDF)
27High levels of AAV vector integration into CRISPR-induced DNA breaks
Nature Communications, 2019, 10,
13.7386Citations (PDF)
28Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
Nature, 2019, 569, 433-437
37.9582Citations (PDF)
29Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
Nature Biotechnology, 2019, 37, 276-282
29.8634Citations (PDF)
30CRISPResso2 provides accurate and rapid genome editing sequence analysis
Nature Biotechnology, 2019, 37, 224-226
29.81,541Citations (PDF)
31Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa
CRISPR Journal, 2018, 1, 55-64
3.5114Citations (PDF)
32Impact of Genetic Variation on CRISPR-Cas Targeting
CRISPR Journal, 2018, 1, 159-170
3.533Citations (PDF)
33Gene therapy comes of age
Science, 2018, 359,
36.21,269Citations (PDF)
34Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
Nature Biomedical Engineering, 2018, 2, 38-47
22.4305Citations (PDF)
35Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”
Nature Methods, 2018, 15, 238-239
24.626Citations (PDF)
36CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease
Molecular Therapy - Nucleic Acids, 2018, 11, 429-440
5.5169Citations (PDF)
37CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data
Nature Methods, 2018, 15, 992-993
24.642Citations (PDF)
38In vivo CRISPR editing with no detectable genome-wide off-target mutations
Nature, 2018, 561, 416-419
37.9303Citations (PDF)
39Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells
Nucleic Acids Research, 2018, 46, 8275-8298
15.593Citations (PDF)
40An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
Nature Biotechnology, 2018, 36, 977-982
29.8413Citations (PDF)
41Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, 38, 1562-1575
6.020Citations (PDF)
42CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
Nature Methods, 2017, 14, 607-614
24.6765Citations (PDF)
43Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway
Blood, 2017, 130, 666-676
4.232Citations (PDF)
44Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors
Nature Methods, 2017, 14, 1163-1166
24.6200Citations (PDF)
45Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
Nature, 2017, 550, 407-410
37.91,115Citations (PDF)
46Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma
Cancer Discovery, 2016, 6, 727-739
25.1152Citations (PDF)
47Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
Nature Reviews Genetics, 2016, 17, 300-312
47.0457Citations (PDF)
48Open-source guideseq software for analysis of GUIDE-seq data
Nature Biotechnology, 2016, 34, 483-483
29.871Citations (PDF)
49Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
Nature Biotechnology, 2016, 34, 869-874
29.8659Citations (PDF)
50High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
Nature, 2016, 529, 490-495
37.92,517Citations (PDF)
51Genome Editing in Human Cells Using CRISPR/Cas Nucleases
Current Protocols in Molecular Biology, 2015, 112,
0.012Citations (PDF)
52Accelerating research through reagent repositories: the genome editing example
Genome Biology, 2015, 16,
8.17Citations (PDF)
53Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing
Human Gene Therapy, 2015, 26, 425-431
3.2133Citations (PDF)
54Fanconi Anemia Gene Editing by the CRISPR/Cas9 System
Human Gene Therapy, 2015, 26, 114-126
3.2107Citations (PDF)
55Chromatin regulation at the frontier of synthetic biology
Nature Reviews Genetics, 2015, 16, 159-171
47.099Citations (PDF)
56Standards needed for gene-editing errors
Nature, 2015, 523, 158-158
37.919Citations (PDF)
57Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Nature, 2015, 523, 481-485
37.91,597Citations (PDF)
58Context influences on TALE–DNA binding revealed by quantitative profiling
Nature Communications, 2015, 6,
13.733Citations (PDF)
59Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model
PLoS Genetics, 2015, 11, e1005239
3.217Citations (PDF)
60Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
Nature Genetics, 2015, 47, 469-478
25.2466Citations (PDF)
61Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
Nature Biotechnology, 2015, 33, 1293-1298
29.8590Citations (PDF)
62Continuous directed evolution of DNA-binding proteins to improve TALEN specificity
Nature Methods, 2015, 12, 939-942
24.6108Citations (PDF)
63Hypoxia drives transient site-specific copy gain and drug-resistant gene expression
Genes and Development, 2015, 29, 1018-1031
4.682Citations (PDF)
64A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing
Molecular and Cellular Biology, 2015, 35, 789-804
2.562Citations (PDF)
65Factor X Mutant Zebrafish Tolerate a Severe Hemostatic Defect in Early Development Yet Develop Lethal Hemorrhage in Adulthood
Blood, 2015, 126, 426-426
4.21Citations (PDF)
66Correction of theCrb1rd8Allele and Retinal Phenotype in C57BL/6N Mice Via TALEN-Mediated Homology-Directed Repair
2014, 55, 387
66Citations (PDF)
67Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage
Genes and Development, 2014, 28, 1957-1975
4.695Citations (PDF)
68Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
Nature Methods, 2014, 11, 429-435
24.6204Citations (PDF)
69CRISPR-Cas systems for editing, regulating and targeting genomes
Nature Biotechnology, 2014, 32, 347-355
29.82,951Citations (PDF)
70Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1
Cell Stem Cell, 2014, 14, 781-795
16.4444Citations (PDF)
71Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
Nature Biotechnology, 2014, 32, 569-576
29.8909Citations (PDF)
72Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
Nature Biotechnology, 2014, 32, 279-284
29.81,899Citations (PDF)
73IκB Kinase β (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor κB (NFκB) Signaling
Journal of Biological Chemistry, 2014, 289, 26960-26972
2.224Citations (PDF)
74Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function
Blood, 2014, 124, 142-150
4.265Citations (PDF)
75GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Nature Biotechnology, 2014, 33, 187-197
29.82,128Citations (PDF)
76Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
Nature Biotechnology, 2014, 33, 73-80
29.81,369Citations (PDF)
77Genome and Epigenome Editing: A Revolution in Science and Medicine
Blood, 2014, 124, SCI-10-SCI-10
4.20Citations (PDF)
78CRISPR RNA–guided activation of endogenous human genes
Nature Methods, 2013, 10, 977-979
24.61,166Citations (PDF)
79Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation
Cell, 2013, 155, 1507-1520
33.7318Citations (PDF)
80Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation‐Based Automatable Solid‐Phase High‐Throughput (FLASH) Assembly
Current Protocols in Molecular Biology, 2013, 103,
0.029Citations (PDF)
81Locus-specific editing of histone modifications at endogenous enhancers
Nature Biotechnology, 2013, 31, 1133-1136
29.8356Citations (PDF)
82Efficient genome editing in zebrafish using a CRISPR-Cas system
Nature Biotechnology, 2013, 31, 227-229
29.82,899Citations (PDF)
83Translating the Genomics Revolution: The Need for an International Gene Therapy Consortium for Monogenic Diseases
Molecular Therapy, 2013, 21, 266-268
10.212Citations (PDF)
84High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Nature Biotechnology, 2013, 31, 822-826
29.83,110Citations (PDF)
85piggyBac transposase tools for genome engineering
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110,
7.5210Citations (PDF)
86Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases
G3: Genes, Genomes, Genetics, 2013, 3, 1707-1715
1.986Citations (PDF)
87A Zebrafish Model Of Antithrombin III Deficiency Displays Bleeding and Thrombosis Secondary To Disseminated Intravascular Coagulation
Blood, 2013, 122, 200-200
4.21Citations (PDF)
88A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions
Cell, 2012, 150, 647-658
33.7318Citations (PDF)
89Engineering Designer Transcription Activator‐‐Like Effector Nucleases (TALENs) by REAL or REAL‐Fast Assembly
Current Protocols in Molecular Biology, 2012, 100,
0.071Citations (PDF)
90FLASH assembly of TALENs for high-throughput genome editing
Nature Biotechnology, 2012, 30, 460-465
29.81,174Citations (PDF)
91TALENs: a widely applicable technology for targeted genome editing
Nature Reviews Molecular Cell Biology, 2012, 14, 49-55
78.21,536Citations (PDF)
92Targeted gene disruption in somatic zebrafish cells using engineered TALENs
Nature Biotechnology, 2011, 29, 697-698
29.8602Citations (PDF)
93Engineering Designer Nucleases with Customized Cleavage Specificities
Current Protocols in Molecular Biology, 2011, 96,
0.016Citations (PDF)
94ZFNGenome: A comprehensive resource for locating zinc finger nuclease target sites in model organisms
BMC Genomics, 2011, 12,
3.350Citations (PDF)
95Reply to “Genome editing with modularly assembled zinc-finger nucleases”
Nature Methods, 2010, 7, 91-92
24.672Citations (PDF)
96Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells
Cell Stem Cell, 2009, 5, 97-110
16.4513Citations (PDF)
97Zinc-finger Nucleases: The Next Generation Emerges
Molecular Therapy, 2008, 16, 1200-1207
10.2324Citations (PDF)
98Synthetic protein–protein interaction domains created by shuffling Cys 2 His 2 zinc‐fingers
Molecular Systems Biology, 2006, 2,
6.721Citations (PDF)
99A Combined Yeast/Bacteria Two-hybrid System
Molecular and Cellular Proteomics, 2005, 4, 819-826
3.021Citations (PDF)
100Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa
Proceedings of the National Academy of Sciences of the United States of America, 2005, 102, 11082-11087
7.5109Citations (PDF)
101Identifying and modifying protein-DNA and protein-protein interactions using a bacterial two-hybrid selection system
Journal of Cellular Biochemistry, 2001, 84, 53-57
3.013Citations (PDF)
102Activation of prokaryotic transcription through arbitrary protein–protein contacts
Nature, 1997, 386, 627-630
37.9290Citations (PDF)
103Nodal patterning without Lefty inhibitory feedback is functional but fragile
ELife, 0, 6,
1.662Citations (PDF)
104Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions
ELife, 0, 12,
1.617Citations (PDF)