| 1 | Blockade of kappa-opioid receptors amplifies microglia-mediated inflammatory responses | 2.4 | 13 | Citations (PDF) |
| 2 | Interactions between 2′-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues and acetylcholine-binding protein inform on potent antagonist activity against nicotinic receptors | 3.2 | 2 | Citations (PDF) |
| 3 | Designer drugs: a medicinal chemistry perspective (II) | 4.1 | 9 | Citations (PDF) |
| 4 | Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives | 2.7 | 10 | Citations (PDF) |
| 5 | Nanobody-enabled monitoring of kappa opioid receptor states | 13.9 | 131 | Citations (PDF) |
| 6 | Effects of chronic treatment with bupropion on self-administration of nicotine + cocaine mixtures in nonhuman primates. | 1.3 | 3 | Citations (PDF) |
| 7 | The selective κ-opioid receptor antagonist JDTic attenuates the alcohol deprivation effect in rats | 1.1 | 10 | Citations (PDF) |
| 8 | Formulation and Characterization of Conjugate Vaccines to Reduce Opioid Use Disorders Suitable for Pharmaceutical Manufacturing and Clinical Evaluation | 4.3 | 18 | Citations (PDF) |
| 9 | Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain | 3.7 | 98 | Citations (PDF) |
| 10 | Synthesis and Characterization of the Selective, Reversible PKC<sub>β</sub> Inhibitor (9<i>S</i>)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9<i>H</i>,18<i>H</i>-5,21:12,17-dimethenodibenzo[<i>e,k</i>]pyrrolo[3,4-<i>h</i>][1,4,13]oxadiazacyclohexadecine-18,20(19<i>H</i>)-dione, Ruboxistaurin (LY333531) | 3.8 | 0 | Citations (PDF) |
| 11 | Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test | 2.3 | 8 | Citations (PDF) |
| 12 | The κ-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats | 2.9 | 7 | Citations (PDF) |
| 13 | Structure of the Nanobody-Stabilized Active State of the Kappa Opioid ReceptorCell, 2018, 172, 55-67.e15 | 34.1 | 348 | Citations (PDF) |
| 14 | Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats | 3.3 | 51 | Citations (PDF) |
| 15 | Caged Naloxone: Synthesis, Characterization, and Stability of 3-<i>O</i>-(4,5-Dimethoxy-2-nitrophenyl)carboxymethyl Naloxone (CNV-NLX) | 3.8 | 4 | Citations (PDF) |
| 16 | A Double-Blind, Placebo-Controlled Trial Demonstrating the Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of RTI-336 | 4.0 | 2 | Citations (PDF) |
| 17 | New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice | 4.4 | 37 | Citations (PDF) |
| 18 | Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3<i>R</i>)-<i>N</i>-[1<i>R</i>)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic) | 5.6 | 6 | Citations (PDF) |
| 19 | Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3<i>R</i>)-7-Hydroxy-<i>N</i>-[(1<i>S</i>)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic) | 5.6 | 10 | Citations (PDF) |
| 20 | Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands | 3.7 | 9 | Citations (PDF) |
| 21 | In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence | 4.4 | 32 | Citations (PDF) |
| 22 | Simple Tetrahydroisoquinolines Are Potent and Selective Kappa Opioid Receptor Antagonists | 3.4 | 11 | Citations (PDF) |
| 23 | Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism | 3.7 | 114 | Citations (PDF) |
| 24 | Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model | 2.3 | 23 | Citations (PDF) |
| 25 | Dissociable effects of the kappa opioid receptor agonist nalfurafine on pain/itch-stimulated and pain/itch-depressed behaviors in male rats | 2.9 | 44 | Citations (PDF) |
| 26 | Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues | 3.8 | 5 | Citations (PDF) |
| 27 | Attenuated nicotine‐like effects of varenicline but not other nicotinic ACh receptor agonists in monkeys receiving nicotine daily | 6.5 | 3 | Citations (PDF) |
| 28 | Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats | 3.8 | 7 | Citations (PDF) |
| 29 | Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists | 3.5 | 10 | Citations (PDF) |
| 30 | Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse | 2.6 | 9 | Citations (PDF) |
| 31 | Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres | 2.6 | 5 | Citations (PDF) |
| 32 | Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response | 5.6 | 32 | Citations (PDF) |
| 33 | In Vitro and in Vivo Neuronal Nicotinic Receptor Properties of (+)- and (−)-Pyrido[3,4]homotropane [(+)- and (−)-PHT]: (+)-PHT Is a Potent and Selective Full Agonist at α6β2 Containing Neuronal Nicotinic Acetylcholine Receptors | 3.8 | 10 | Citations (PDF) |
| 34 | Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents | 2.6 | 16 | Citations (PDF) |
| 35 | Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor | 2.7 | 33 | Citations (PDF) |
| 36 | Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3′-(substituted pyridinyl)-deschloroepibatidine analogs | 2.6 | 1 | Citations (PDF) |
| 37 | Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1<i>S</i>,3a<i>S</i>)-2,3,3a,4,5,6-Hexahydro-1<i>H</i>-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198) | 3.8 | 16 | Citations (PDF) |
| 38 | Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice | 4.4 | 33 | Citations (PDF) |
| 39 | Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in micePain, 2015, 156, 1153-1160 | 4.4 | 86 | Citations (PDF) |
| 40 | The Discovery and Development of the <i>N</i>‐Substituted <i>trans</i>‐3,4‐Dimethyl‐4‐(3′‐hydroxyphenyl)piperidine Class of Pure Opioid Receptor Antagonists | 3.1 | 21 | Citations (PDF) |
| 41 | Simple Radiometric Method for Accurately Quantitating Epitope Densities of Hapten–Protein Conjugates with Sulfhydryl Linkages | 3.9 | 8 | Citations (PDF) |
| 42 | Effect of the 3- and 4-Methyl Groups on the Opioid Receptor Properties of N-Substituted <i>trans</i>-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines | 5.6 | 8 | Citations (PDF) |
| 43 | Emergence and properties of spice and bath salts: A medicinal chemistry perspective | 4.7 | 66 | Citations (PDF) |
| 44 | Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2′-Fluoro-3′-(substituted pyridinyl)-7-deschloroepibatidine Analogues | 5.6 | 16 | Citations (PDF) |
| 45 | Design, Synthesis, and Biological Evaluation of (3<i>R</i>)-1,2,3,4-Tetrahydro-7-hydroxy-<i>N</i>-[(1<i>S</i>)-1-[[(3<i>R</i>,4<i>R</i>)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profile | 5.6 | 24 | Citations (PDF) |
| 46 | Discriminative stimulus and hypothermic effects of some derivatives of the nAChR agonist epibatidine in mice | 2.9 | 16 | Citations (PDF) |
| 47 | 4β-Methyl-5-(3-hydroxyphenyl)morphan Opioid Agonist and Partial Agonist Derived from a 4β-Methyl-5-(3-hydroxyphenyl)morphan Pure Antagonist | 5.6 | 7 | Citations (PDF) |
| 48 | Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food | 3.2 | 48 | Citations (PDF) |
| 49 | Patterns of nicotinic receptor antagonism II: Cardiovascular effects in rats | 3.0 | 26 | Citations (PDF) |
| 50 | Discovery of <i>N</i>-{4-[(3-Hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide Analogues as Selective Kappa Opioid Receptor Antagonists | 5.6 | 15 | Citations (PDF) |
| 51 | Effects of Chronic Varenicline Treatment on Nicotine, Cocaine, and Concurrent Nicotine+Cocaine Self-Administration | 5.5 | 23 | Citations (PDF) |
| 52 | Influence of chronic dopamine transporter inhibition by RTI-336 on motor behavior, sleep, and hormone levels in rhesus monkeys. | 1.3 | 6 | Citations (PDF) |
| 53 | Corticotropin-Releasing Factor (CRF)-Induced Disruption of Attention in Rats Is Blocked by the κ-Opioid Receptor Antagonist JDTic | 5.5 | 53 | Citations (PDF) |
| 54 | Structure of the human κ-opioid receptor in complex with JDTic | 38.7 | 855 | Citations (PDF) |
| 55 | Synthesis and Nicotinic Acetylcholine Receptor in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-3′-(substituted phenyl)deschloroepibatidine Analogues of 2′-Fluoro-3′-(4-nitrophenyl)deschloroepibatidine | 5.6 | 27 | Citations (PDF) |
| 56 | Designer drugs: a medicinal chemistry perspective | 4.1 | 131 | Citations (PDF) |
| 57 | The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats | 2.4 | 41 | Citations (PDF) |
| 58 | The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety | 2.7 | 95 | Citations (PDF) |
| 59 | Synthesis of 2-(Substituted Phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine | 5.6 | 9 | Citations (PDF) |
| 60 | Kappa Opioid Receptor Signaling in the Basolateral Amygdala Regulates Conditioned Fear and Anxiety in Rats | 5.5 | 125 | Citations (PDF) |
| 61 | Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines | 5.6 | 46 | Citations (PDF) |
| 62 | Duration of Action of a Broad Range of Selective κ-Opioid Receptor Antagonists Is Positively Correlated with c-Jun N-Terminal Kinase-1 Activation | 2.7 | 98 | Citations (PDF) |
| 63 | Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113 | 4.4 | 14 | Citations (PDF) |
| 64 | Synthesis and evaluation of 1,2,4-methyltriazines as mGluR5 antagonists | 2.6 | 6 | Citations (PDF) |
| 65 | Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam | 3.4 | 11 | Citations (PDF) |
| 66 | Preparation of a series of 5-methyl-3-(substituted)-[1,2,4]triazines | 1.4 | 2 | Citations (PDF) |
| 67 | Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 3′-(Substituted Phenyl)epibatidine Analogues. Nicotinic Partial Agonists | 3.6 | 15 | Citations (PDF) |
| 68 | Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents | 2.9 | 40 | Citations (PDF) |
| 69 | Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats | 2.9 | 89 | Citations (PDF) |
| 70 | Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement in rats | 2.9 | 37 | Citations (PDF) |
| 71 | Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates | 2.4 | 11 | Citations (PDF) |
| 72 | Effects of Hydroxymetabolites of Bupropion on Nicotine Dependence Behavior in Mice | 3.3 | 41 | Citations (PDF) |
| 73 | Synthesis and Characterization of in Vitro and in Vivo Profiles of Hydroxybupropion Analogues: Aids to Smoking Cessation | 5.6 | 47 | Citations (PDF) |
| 74 | Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Smoking Cessation | 5.6 | 66 | Citations (PDF) |
| 75 | Analogues of (3<i>R</i>)-7-Hydroxy-<i>N</i>-[(1<i>S</i>)-1-{[(3<i>R</i>,4<i>R</i>)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in Vitro and in Vivo Opioid Receptor Antagonist Activity | 5.6 | 26 | Citations (PDF) |
| 76 | 1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists | 3.4 | 12 | Citations (PDF) |
| 77 | Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2β-substituted Tropanes | 5.6 | 6 | Citations (PDF) |
| 78 | High specific activity (+)‐amphetamine and (+)‐methamphetamine | 0.9 | 3 | Citations (PDF) |
| 79 | Positive allosteric modulation of the human cannabinoid (CB<sub>1</sub>) receptor by RTI‐371, a selective inhibitor of the dopamine transporter | 6.5 | 76 | Citations (PDF) |
| 80 | Synthesis and structure–activity relationship of 3β-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters | 2.6 | 5 | Citations (PDF) |
| 81 | Synthesis and In Vitro Opioid Receptor Functional Antagonism of Methyl-Substituted Analogues of (3<i>R</i>)-7-Hydroxy-<i>N</i>-[(1<i>S</i>)-1-{[(3<i>R</i>,4<i>R</i>)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) | 5.6 | 20 | Citations (PDF) |
| 82 | Functional and biological determinants affecting the duration of action and efficacy of anti-(+)-methamphetamine monoclonal antibodies in rats | 3.2 | 28 | Citations (PDF) |
| 83 | Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Cocaine Addiction | 5.6 | 152 | Citations (PDF) |
| 84 | The Synthesis of Haptens and Their Use for the Development of Monoclonal Antibodies for Treating Methamphetamine Abuse | 5.6 | 34 | Citations (PDF) |
| 85 | Epibatidine Analogs Synthesized for Characterization of Nicotinic Pharmacophores—A Review | 0.4 | 28 | Citations (PDF) |
| 86 | Preparation of carbon‐14 labeled (3<i>R</i>)‐7‐hydroxy‐N‐(1<i>S</i>)‐1‐{[(3<i>R</i>,4<i>R</i>)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethyl‐1‐piperidinyl]methyl}‐2‐methylpropyl‐1,2,3,4‐tetrahydroisoquinolinecarboxamide (JDTic) | 0.9 | 1 | Citations (PDF) |
| 87 | A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay | 2.6 | 10 | Citations (PDF) |
| 88 | Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3′-(substituted phenyl)deschloroepibatidine analogs | 2.6 | 16 | Citations (PDF) |
| 89 | Synthesis and receptor binding properties of 2β-alkynyl and 2β-(1,2,3-triazol)substituted 3β-(substituted phenyl)tropane derivatives | 2.6 | 6 | Citations (PDF) |
| 90 | Synthesis and monoamine transporter binding properties of 2β-[3′-(substituted benzyl)isoxazol-5-yl]- and 2β-[3′-methyl-4′-(substituted phenyl)isoxazol-5-yl]-3β-(substituted phenyl)tropanes | 2.6 | 6 | Citations (PDF) |
| 91 | 3′-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for α4β2 versus α3β4 nAChRs | 4.4 | 5 | Citations (PDF) |
| 92 | Synthesis and In Vitro Opioid Receptor Functional Antagonism of Analogues of the Selective Kappa Opioid Receptor Antagonist (3<i>R</i>)-7-Hydroxy-<i>N</i>-((1<i>S</i>)-1-{[(3<i>R</i>,4<i>R</i>)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) | 5.6 | 22 | Citations (PDF) |
| 93 | Antagonists at Metabotropic Glutamate Receptor Subtype 5 | 4.1 | 51 | Citations (PDF) |
| 94 | mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo | 2.5 | 22 | Citations (PDF) |
| 95 | Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys | 2.4 | 42 | Citations (PDF) |
| 96 | Development of 3-Phenyltropane Analogues with High Affinity for the Dopamine and Serotonin Transporters and Low Affinity for the Norepinephrine Transporter | 5.6 | 10 | Citations (PDF) |
| 97 | Improved Synthesis of the ORL Antagonist 1-[(3R,4R)-1-Cyclooctylmethyl-3-ethoxycarbonyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) | 1.7 | 1 | Citations (PDF) |
| 98 | Effects of Combined Dopamine and Serotonin Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys | 3.3 | 70 | Citations (PDF) |
| 99 | Improved Procedure for the Synthesis of DAMGO | 1.7 | 1 | Citations (PDF) |
| 100 | Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of Bridged and Fused Ring Analogues of Epibatidine | 5.6 | 39 | Citations (PDF) |
| 101 | Anxiolytic-Like Effects of κ-Opioid Receptor Antagonists in Models of Unlearned and Learned Fear in Rats | 3.3 | 222 | Citations (PDF) |
| 102 | Synthesis and Pharmacological Evaluation of Phenylethynyl[1,2,4]methyltriazines as Analogues of 3-Methyl-6-(phenylethynyl)pyridine | 5.6 | 24 | Citations (PDF) |
| 103 | Using Hapten Design to Discover Therapeutic Monoclonal Antibodies for Treating Methamphetamine Abuse | 3.3 | 68 | Citations (PDF) |
| 104 | Synthesis, Monoamine Transporter Binding, Properties, and Functional Monoamine Uptake Activity of 3β-[4-Methylphenyl and 4-Chlorophenyl]-2β-[5-(Substituted phenyl)thiazol-2-yl]tropanes | 5.6 | 9 | Citations (PDF) |
| 105 | Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs | 2.6 | 20 | Citations (PDF) |
| 106 | Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys | 2.4 | 51 | Citations (PDF) |
| 107 | Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse | 3.1 | 42 | Citations (PDF) |
| 108 | Synthesis and Monoamine Transporter Binding Properties of 2,3-Cyclo Analogues of 3β-(4‘-Aminophenyl)-2β-tropanemethanol | 5.6 | 3 | Citations (PDF) |
| 109 | N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)-7α-amidomorphans Are Potent, Selective κ Opioid Receptor Antagonists | 5.6 | 23 | Citations (PDF) |
| 110 | Highly Potent and Selective Phenylmorphan-Based Inverse Agonists of the Opioid δ Receptor | 5.6 | 18 | Citations (PDF) |
| 111 | Synthesis and Pharmacological Characterization of Nicotinic Acetylcholine Receptor Properties of (+)- and (−)-Pyrido-[3,4-b]homotropanes | 5.6 | 19 | Citations (PDF) |
| 112 | Effects of dopamine transporter selective 3-phenyltropane analogs on locomotor activity, drug discrimination, and cocaine self-administration after oral administration | 4.4 | 20 | Citations (PDF) |
| 113 | Dopamine Transporter Ligands: Recent Developments and Therapeutic Potential | 3.0 | 70 | Citations (PDF) |
| 114 | 2-Fluoro-3-(4-nitro-phenyl)deschloroepibatidine Is a Novel Potent Competitive Antagonist of Human Neuronal α4β2 nAChRs | 2.7 | 18 | Citations (PDF) |
| 115 | Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product | 2.6 | 4 | Citations (PDF) |
| 116 | Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 3‘-Substituted Deschloroepibatidine Analogues. Novel Nicotinic Antagonists | 5.6 | 31 | Citations (PDF) |
| 117 | Effects of JDTic, a selective κ-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model | 4.4 | 40 | Citations (PDF) |
| 118 | Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter | 2.5 | 25 | Citations (PDF) |
| 119 | Tritiation of the cannabinoid receptor antagonist SR144528 involving lithium aluminum tritide reduction; assessment of the kinetic isotope effect by3H-NMR | 0.9 | 6 | Citations (PDF) |
| 120 | Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats | 2.9 | 277 | Citations (PDF) |
| 121 | Synthesis and Pharmacological Characterization of exo-2-(2‘-Chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as Novel Epibatidine Analogues | 5.6 | 14 | Citations (PDF) |
| 122 | Synthesis and Monoamine Transporter Binding Properties of 3α-(Substituted phenyl)nortropane-2β-carboxylic Acid Methyl Esters. Norepinephrine Transporter Selective Compounds | 5.6 | 11 | Citations (PDF) |
| 123 | Synthesis and Monoamine Transporter Binding Properties of 2,3-Diaryltropanes | 5.6 | 5 | Citations (PDF) |
| 124 | N-Substituted cis-4a-(3-Hydroxyphenyl)-8a-methyloctahydroisoquinolines Are Opioid Receptor Pure Antagonists | 5.6 | 18 | Citations (PDF) |
| 125 | Bupropion increases striatal vesicular monoamine transport | 4.4 | 68 | Citations (PDF) |
| 126 | Synthesis and Monoamine Transporter Binding Properties of 3β-(3‘,4‘-Disubstituted phenyl)tropane-2β-carboxylic Acid Methyl Esters | 5.6 | 14 | Citations (PDF) |
| 127 | A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants | 5.5 | 33 | Citations (PDF) |
| 128 | Enantioselective Effects of Hydroxy Metabolites of Bupropion on Behavior and on Function of Monoamine Transporters and Nicotinic Receptors | 2.7 | 206 | Citations (PDF) |
| 129 | Effects of Dopamine Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys: Relationship to Transporter Occupancy Determined by Positron Emission Tomography Neuroimaging | 3.3 | 61 | Citations (PDF) |
| 130 | Corrigendum to “Epibatidine structure–activity relationships” | 2.1 | 0 | Citations (PDF) |
| 131 | Epibatidine structure–activity relationships | 2.1 | 70 | Citations (PDF) |
| 132 | Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists | 5.6 | 27 | Citations (PDF) |
| 133 | Monoamine Transporter Binding, Locomotor Activity, and Drug Discrimination Properties of 3-(4-Substituted-phenyl)tropane-2-carboxylic Acid Methyl Ester Isomers | 5.6 | 37 | Citations (PDF) |
| 134 | Synthesis, Monoamine Transporter Binding Properties, and Behavioral Pharmacology of a Series of 3β-(Substituted phenyl)-2β-(3‘-substituted isoxazol-5-yl)tropanes | 5.6 | 44 | Citations (PDF) |
| 135 | Discovery of the First N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphan To Possess Highly Potent and Selective Opioid δ Receptor Antagonist Activity | 5.6 | 18 | Citations (PDF) |
| 136 | Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2‘-Fluoro-3‘-(substituted phenyl)deschloroepibatidine Analogues. Novel Nicotinic Antagonist | 5.6 | 46 | Citations (PDF) |
| 137 | Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist | 5.6 | 76 | Citations (PDF) |
| 138 | Effects of Pyridine Ring Substitutions on Affinity, Efficacy, and Subtype Selectivity of Neuronal Nicotinic Receptor Agonist Epibatidine | 3.3 | 36 | Citations (PDF) |
| 139 | Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans | 5.6 | 28 | Citations (PDF) |
| 140 | Synthesis and Transporter Binding Properties of 3β-[4‘-(Phenylalkyl, -phenylalkenyl, and -phenylalkynl)phenyl]tropane-2β-carboxylic Acid Methyl Esters: Evidence of a Remote Phenyl Binding Domain on the Dopamine Transporter | 5.6 | 14 | Citations (PDF) |
| 141 | Tritiation of SR141716 by metallation-iodination-reduction: tritium-proton nOe study | 0.9 | 14 | Citations (PDF) |
| 142 | Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2-exo-2-(2‘,3‘-Disubstituted 5‘-pyridinyl)-7-azabicyclo[2.2.1]heptanes: Epibatidine Analogues | 5.6 | 50 | Citations (PDF) |
| 143 | Identification of the Firsttrans-(3R,4R)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective Opioid κ Receptor Antagonist Activity | 5.6 | 113 | Citations (PDF) |
| 144 | Locomotor stimulant effects of novel phenyltropanes in the mouse | 3.0 | 20 | Citations (PDF) |
| 145 | Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2-exo-2-(2‘-Substituted 5‘-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine Analogues | 5.6 | 81 | Citations (PDF) |
| 146 | Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2-exo-2-(2‘-Substituted-3‘-phenyl-5‘-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel Nicotinic Antagonist | 5.6 | 43 | Citations (PDF) |
| 147 | Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human ?-opioid receptor | 1.6 | 4 | Citations (PDF) |
| 148 | Anticocaine catalytic antibodies have no affinity for RTI compounds: Implications for treatment | 1.6 | 5 | Citations (PDF) |
| 149 | Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [35S]GTP-?-S functional binding assay | 1.6 | 32 | Citations (PDF) |
| 150 | Factors Influencing Agonist Potency and Selectivity for the Opioid δ Receptor Are Revealed in Structure−Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides | 5.6 | 16 | Citations (PDF) |
| 151 | Synthesis of [125I]-3?-(4-ethyl-3-iodophenyl)nortropane-2?-carboxylic acid methyl ester ([125I]EINT) | 0.9 | 3 | Citations (PDF) |
| 152 | RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro | 2.7 | 9 | Citations (PDF) |
| 153 | Synthesis and Pharmacological Characterization of [125I]Iodomethyllycaconitine ([125I]Iodo-MLA). A New Ligand for the α7Nicotinic Acetylcholine Receptor | 5.6 | 32 | Citations (PDF) |
| 154 | (±)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor | 2.1 | 15 | Citations (PDF) |
| 155 | Serotonin transporter production and degradation rates: studies with RTI-76 | 2.5 | 25 | Citations (PDF) |
| 156 | Opioid peptide receptor studies, 11: Involvement of Tyr148, Trp318 and His319 of the rat ?-opioid receptor in binding of ?-selective ligands 1999, 32, 23-28 | | 43 | Citations (PDF) |
| 157 | Synthesis of 3β-(4-[125I]iodophenyl)tropane-2-β-pyrrolidine carboxamide ([125I]RTI-229) | 0.9 | 3 | Citations (PDF) |
| 158 | Synthesis of [1-3H]morphine-6-β-D-glucuronide | 0.9 | 5 | Citations (PDF) |
| 159 | Asymmetric Synthesis of 9-Alkyl-2-benzyl-6,7-benzomorphans: Characterization as Novel σ Receptor Ligands | 5.6 | 8 | Citations (PDF) |
| 160 | Protection of the allylic alcohol double bond from catalytic reduction in the preparation of [1-3H]morphine and [1-3H]codeine 1998, 41, 811-821 | | 9 | Citations (PDF) |
| 161 | Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat ? opioid receptor | 1.6 | 12 | Citations (PDF) |
| 162 | RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter | 1.6 | 32 | Citations (PDF) |
| 163 | New synthesis of 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]hept-2-ene. A key intermediate in the synthesis of epibatidine and analogs | 1.4 | 25 | Citations (PDF) |
| 164 | Identification of an Opioid κ Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine | 5.6 | 62 | Citations (PDF) |
| 165 | N-Substituted 9β-Methyl-5-(3-hydroxyphenyl)morphans Are Opioid Receptor Pure Antagonists | 5.6 | 37 | Citations (PDF) |
| 166 | Synthesis and Ligand Binding of Tropane Ring Analogues of Paroxetine | 5.6 | 21 | Citations (PDF) |
| 167 | Investigation of the N-Substituent Conformation Governing Potency and μ Receptor Subtype-Selectivity in (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)- piperidine Opioid Antagonists | 5.6 | 42 | Citations (PDF) |
| 168 | 3β-(4-Ethyl-3-iodophenyl)nortropane-2β- carboxylic Acid Methyl Ester as a High-Affinity Selective Ligand for the Serotonin Transporter | 5.6 | 46 | Citations (PDF) |
| 169 | Synthesis and Nicotinic Acetylcholine Receptor Binding Properties ofexo-2-(2‘-Fluoro-5‘-pyridinyl)-7-azabicyclo- [2.2.1]heptane: A New Positron Emission Tomography Ligand for Nicotinic Receptors | 5.6 | 63 | Citations (PDF) |
| 170 | N-substituted phenyltropanes as in vivo binding ligands for rapid imaging studies of the dopamine transporter | 1.6 | 47 | Citations (PDF) |
| 171 | RTI-352: A 3? analogue of RTI-55 as an in vivo dopamine transporter binding ligand 1997, 25, 389-392 | | 1 | Citations (PDF) |
| 172 | Synthesis, Ligand Binding, and Quantitative Structure−Activity Relationship Study of 3β-(4‘-Substituted phenyl)-2β-heterocyclic Tropanes: Evidence for an Electrostatic Interaction at the 2β-Position | 5.6 | 69 | Citations (PDF) |
| 173 | 3α-(4‘-Substituted phenyl)tropane- 2β-carboxylic Acid Methyl Esters: Novel Ligands with High Affinity and Selectivity at the Dopamine Transporter | 5.6 | 34 | Citations (PDF) |
| 174 | Synthesis and Transporter Binding Properties of 3β-(4‘-Alkyl-, 4‘-alkenyl-, and 4‘-alkynylphenyl)nortropane-2β-carboxylic Acid Methyl Esters: Serotonin Transporter Selective Analogs | 5.6 | 53 | Citations (PDF) |
| 175 | Benzyne addition to N-alkyl-4-hydroxy-1-methylisoquinolinium salts; a new and convenient synthesis of (±)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5,10-imine (MK801) | 3.4 | 16 | Citations (PDF) |
| 176 | Mapping nicotinic acetylcholine receptors with PET 1996, 24, 403-407 | | 71 | Citations (PDF) |
| 177 | In vivo labeling of neuronal nicotinic acetylcholine receptors with radiolabeled isomers of norchloroepibatidine | 1.5 | 26 | Citations (PDF) |
| 178 | Development of imaging agents for the dopamine transporter | 13.8 | 33 | Citations (PDF) |
| 179 | Facile synthesis of (±)‐, (+)‐, and (‐)‐galanthamine | 2.2 | 39 | Citations (PDF) |
| 180 | Title is missing! | 3.8 | 2 | Citations (PDF) |
| 181 | PRACTICAL SYNTHESIS AND CHARACTERIZATION OF 7-BENZYLIDENENALTREXONE (BNTX) | 2.0 | 5 | Citations (PDF) |
| 182 | Enantiomers of Diastereomeric cis-N-[1-(2-Hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamides: Synthesis, X-ray Analysis, and Biological Activities | 5.6 | 35 | Citations (PDF) |
| 183 | Synthesis and .sigma. Binding Properties of 2'-Substituted 5,9.alpha.-Dimethyl-6,7-benzomorphans | 5.6 | 25 | Citations (PDF) |
| 184 | RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-[1-(2 thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain | 1.6 | 5 | Citations (PDF) |
| 185 | Metallation/reduction as a new approach to tritium labeling. The synthesis of [3H]ibogaine | 0.9 | 7 | Citations (PDF) |
| 186 | Synthesis and structural determination of 5<i>H</i>‐benzocyclohepten‐5,8‐imines | 2.2 | 19 | Citations (PDF) |
| 187 | Secondary Amine Analogs of 3.beta.-(4'-Substituted phenyl)tropane-2.beta.-carboxylic Acid Esters and N-Norcocaine Exhibit Enhanced Affinity for Serotonin and Norepinephrine Transporters | 5.6 | 91 | Citations (PDF) |
| 188 | Title is missing! | 3.8 | 19 | Citations (PDF) |
| 189 | Radiosynthesis of a photoaffinity probe for the cocaine receptor of the dopamine transporter: 3β-(p-chlorophenyl)tropan-2β-carboxylic acid m-([125I]-iodo)-p-azidophenethyl ester ([125I]-RTI-82) | 0.9 | 20 | Citations (PDF) |
| 190 | [125I]RTI-55 Binding to Cocaine-Sensitive Dopaminergic and Serotonergic Uptake Sites in the Human Brain | 3.9 | 55 | Citations (PDF) |
| 191 | 3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogs of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters | 5.6 | 117 | Citations (PDF) |
| 192 | Stimulus generalization from cocaine to analogs with high in vitro affinity for dopamine uptake sites | 3.1 | 22 | Citations (PDF) |
| 193 | Isopropyl and phenyl esters of 3.beta.-(4-substituted phenyl)tropan-2.beta.-carboxylic acids. Potent and selective compounds for the dopamine transporter | 5.6 | 83 | Citations (PDF) |
| 194 | 2.beta.-Substituted analogs of cocaine. Synthesis and inhibition of binding to the cocaine receptor | 5.6 | 84 | Citations (PDF) |
| 195 | A cocaine analog and a GBR analog label the same protein in rat striatal membranes | 2.5 | 18 | Citations (PDF) |
| 196 | In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine-123 labeled RTI-55 | 1.6 | 85 | Citations (PDF) |
| 197 | In vivo binding of [125I] RTI-55 to dopamine transporters: Pharmacology and regional distribution with autoradiography | 1.6 | 68 | Citations (PDF) |
| 198 | Title is missing! | 3.8 | 8 | Citations (PDF) |
| 199 | Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogs at the dopamine transporter | 5.6 | 307 | Citations (PDF) |
| 200 | Synthesis and ligand binding of cocaine isomers at the cocaine receptor | 5.6 | 77 | Citations (PDF) |
| 201 | Synthesis, ligand binding, QSAR, and CoMFA study of 3.beta.-(p-substituted phenyl)tropane-2.beta.-carboxylic acid methyl esters | 5.6 | 193 | Citations (PDF) |
| 202 | SYNTHESIS OF POTENTIAL 1-[1-(2-THIENYL)CYCLOHEXYL]PIPERIDINE METABOLITES | 2.0 | 1 | Citations (PDF) |
| 203 | Solid-state and solution conformations of methadone hydrochloride and related compounds | 1.4 | 2 | Citations (PDF) |
| 204 | AN IMPROVED SYNTHESIS OF 1,4-BIS(2′-METHYL-6′-KIHYLANILINO)ANTHRAQUINONE | 2.0 | 1 | Citations (PDF) |
| 205 | A practical synthesis of (+)‐cocaine | 2.2 | 27 | Citations (PDF) |
| 206 | Synthesis and spectral properties of optically active 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine: Primary methadone metabolite | 2.2 | 1 | Citations (PDF) |
| 207 | SYNTHESIS OF 4-(4′-HYDROXYPIPERIDINO)-4-PHENYLCYCLOHEXANOL, A DIHYDROXY PHENCYCLIDINE METABOLITE | 2.0 | 3 | Citations (PDF) |
| 208 | Synthesis of naphthyridinone derivatives as potential antimalarials | 2.2 | 14 | Citations (PDF) |
| 209 | SYNTHESIS OF (R)-5-ALKYL-5-(1'-METHYL-3'-CARBOXYPROPYL) BARBITURIC ACIDS AND (R)-ALKYL-5-(1'-METHYL-3-CARBOXYPROPYL)-2-THIOBARBITURIC ACIDS | 2.0 | 2 | Citations (PDF) |
| 210 | Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats | 2.8 | 21 | Citations (PDF) |
