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250 papers • 73,544 citations • Sorted by year • Download PDF (PDF by citations)
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1CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes
Nucleic Acids Research, 2024, 52, D590-D596
16.214Citations (PDF)
2In vivo human T cell engineering with enveloped delivery vehicles
Nature Biotechnology, 2024, 42, 1684-1692
18.145Citations (PDF)
3Engineering self-deliverable ribonucleoproteins for genome editing in the brain14.114Citations (PDF)
4Targeted nonviral delivery of genome editors in vivo7.713Citations (PDF)
5An essential and highly selective protein import pathway encoded by nucleus-forming phage7.75Citations (PDF)
6Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9
Cell, 2024, 187, 3249-3261.e14
35.114Citations (PDF)
7Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases
Science, 2024, 385, 538-543
38.23Citations (PDF)
8Birth of protein folds and functions in the virome
Nature, 2024, 633, 710-717
40.17Citations (PDF)
9Oligomeric State and Drug Binding of the SARS-CoV-2 Envelope Protein Are Sensitive to the Ectodomain15.74Citations (PDF)
10Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein18.14Citations (PDF)
11Genome editing in plants using the compact editor CasΦ7.725Citations (PDF)
12Precise transcript targeting by CRISPR-Csm complexes
Nature Biotechnology, 2023, 41, 1256-1264
18.139Citations (PDF)
13CRISPR technology: A decade of genome editing is only the beginning
Science, 2023, 379,
38.2449Citations (PDF)
14To TnpB or not TnpB? Cas12 is the answer
Nature Chemical Biology, 2023, 19, 263-264
7.31Citations (PDF)
15Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP614.126Citations (PDF)
16Genome expansion by a CRISPR trimmer-integrase
Nature, 2023, 618, 855-861
40.19Citations (PDF)
17Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs
Molecular Therapy, 2023, 31, 2422-2438
10.515Citations (PDF)
18Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
Cell, 2023, 186, 4567-4582.e20
35.160Citations (PDF)
19Assembly of SARS-CoV-2 ribonucleosomes by truncated N∗ variant of the nucleocapsid protein2.311Citations (PDF)
20Infant microbiome cultivation and metagenomic analysis reveal Bifidobacterium 2’-fucosyllactose utilization can be facilitated by coexisting species14.19Citations (PDF)
21Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes
Nucleic Acids Research, 2023, 51, 12414-12427
16.213Citations (PDF)
22Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity
Molecular Cell, 2022, 82, 1199-1209.e6
14.238Citations (PDF)
23Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
Cell, 2022, 185, 1539-1548.e5
35.1117Citations (PDF)
24A functional map of HIV-host interactions in primary human T cells14.128Citations (PDF)
25CRISPR–Cas9 bends and twists DNA to read its sequence6.441Citations (PDF)
26Crystal structure of an RNA/DNA strand exchange junction
PLoS ONE, 2022, 17, e0263547
2.53Citations (PDF)
27Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022, 20, 641-656
27.5103Citations (PDF)
28Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination
Nature, 2022, 607, 351-355
40.1144Citations (PDF)
29A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression
Molecular Cell, 2022, 82, 2148-2160.e4
14.234Citations (PDF)
30Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles7.7114Citations (PDF)
31Borgs are giant genetic elements with potential to expand metabolic capacity
Nature, 2022, 610, 731-736
40.131Citations (PDF)
32Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing
Nature Microbiology, 2022, 7, 1967-1979
12.850Citations (PDF)
33Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors
Cell, 2022, 185, 4574-4586.e16
35.171Citations (PDF)
34Decorating chromatin for enhanced genome editing using CRISPR-Cas97.720Citations (PDF)
35Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy
Cell, 2021, 184, 323-333.e9
35.1654Citations (PDF)
36Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems
Nature Microbiology, 2021, 6, 354-365
12.8122Citations (PDF)
37Human Molecular Genetics and Genomics — Important Advances and Exciting Possibilities25.539Citations (PDF)
38Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement
Science Advances, 2021, 7,
11.328Citations (PDF)
39Cancer-specific loss of <i>TERT</i> activation sensitizes glioblastoma to DNA damage7.733Citations (PDF)
40The NIH Somatic Cell Genome Editing program
Nature, 2021, 592, 195-204
40.182Citations (PDF)
41Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex14.113Citations (PDF)
42Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus
PLoS ONE, 2021, 16, e0251296
2.515Citations (PDF)
43DNA interference states of the hypercompact CRISPR–CasΦ effector6.456Citations (PDF)
44Accelerated RNA detection using tandem CRISPR nucleases
Nature Chemical Biology, 2021, 17, 982-988
7.3157Citations (PDF)
45Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples
PLoS ONE, 2021, 16, e0255690
2.514Citations (PDF)
46Synthesis of Multi-Protein Complexes through Charge-Directed Sequential Activation of Tyrosine Residues15.720Citations (PDF)
47Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics
IScience, 2021, 24, 102996
3.873Citations (PDF)
48Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules14.128Citations (PDF)
49LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples
PLoS ONE, 2021, 16, e0258263
2.56Citations (PDF)
50Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment
Epidemics, 2021, 37, 100527
2.424Citations (PDF)
51Species- and site-specific genome editing in complex bacterial communities
Nature Microbiology, 2021, 7, 34-47
12.8148Citations (PDF)
52Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery
Acta Biomaterialia, 2020, 114, 358-368
9.375Citations (PDF)
53Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
Journal of Biological Chemistry, 2020, 295, 14473-14487
2.368Citations (PDF)
54Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine–Cysteine Bond Formation
ACS Central Science, 2020, 6, 1564-1571
9.667Citations (PDF)
55Blueprint for a pop-up SARS-CoV-2 testing lab
Nature Biotechnology, 2020, 38, 791-797
18.134Citations (PDF)
56Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
Nature Biotechnology, 2020, 38, 883-891
18.1563Citations (PDF)
57Potent CRISPR-Cas9 inhibitors from<i>Staphylococcus</i>genomes7.748Citations (PDF)
58Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling7.761Citations (PDF)
59A scoutRNA Is Required for Some Type V CRISPR-Cas Systems
Molecular Cell, 2020, 79, 416-424.e5
14.257Citations (PDF)
60Clades of huge phages from across Earth’s ecosystems
Nature, 2020, 578, 425-431
40.1303Citations (PDF)
61The promise and challenge of therapeutic genome editing
Nature, 2020, 578, 229-236
40.1667Citations (PDF)
62Machine learning predicts new anti-CRISPR proteins
Nucleic Acids Research, 2020, 48, 4698-4708
16.271Citations (PDF)
63Controlling and enhancing CRISPR systems
Nature Chemical Biology, 2020, 17, 10-19
7.3123Citations (PDF)
64Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
Nature Biotechnology, 2020, 39, 84-93
18.182Citations (PDF)
65Attachment of a 32P-phosphate to the 3′ Terminus of a DNA Oligonucleotide
Bio-protocol, 2020, 10,
0.81Citations (PDF)
66Author response: CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
2020, ,
0Citations (PDF)
67Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble14.133Citations (PDF)
68CRISPR's unwanted anniversary
Science, 2019, 366, 777-777
38.211Citations (PDF)
69A Functional Mini-Integrase in a Two-Protein Type V-C CRISPR System
Molecular Cell, 2019, 73, 727-737.e3
14.219Citations (PDF)
70Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response
Cell Host and Microbe, 2019, 25, 242-249.e3
15.216Citations (PDF)
71Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC214.150Citations (PDF)
72Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs14.1134Citations (PDF)
73Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics
ACS Central Science, 2019, 5, 651-662
9.692Citations (PDF)
74Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules7.7124Citations (PDF)
75Broad-spectrum enzymatic inhibition of CRISPR-Cas12a6.487Citations (PDF)
76The NAI Fellow Profile: An Interview with Dr. Jennifer Doudna
Technology and Innovation, 2019, 20, 475-481
0.40Citations (PDF)
77Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules7.73Citations (PDF)
78Temperature-Responsive Competitive Inhibition of CRISPR-Cas9
Molecular Cell, 2019, 73, 601-610.e5
14.256Citations (PDF)
79CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
Cell, 2019, 176, 254-267.e16
35.175Citations (PDF)
80CasX enzymes comprise a distinct family of RNA-guided genome editors
Nature, 2019, 566, 218-223
40.1327Citations (PDF)
81CRISPR System: From Adaptive Immunity to Genome Editing
2019, , 81-116
0Citations (PDF)
82Author response: Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a
2019, ,
1Citations (PDF)
83Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing15.7130Citations (PDF)
84Programmable RNA recognition using a CRISPR-associated Argonaute7.737Citations (PDF)
85Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies15.066Citations (PDF)
86Genome im Fokus: Entwicklung und Anwendungen von CRISPR‐Cas9‐Bildgebungstechnologien
Angewandte Chemie, 2018, 130, 4412-4420
1.55Citations (PDF)
87A Unified Resource for Tracking Anti-CRISPR Names
CRISPR Journal, 2018, 1, 304-305
3.787Citations (PDF)
88Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain3.879Citations (PDF)
89Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner
Cancer Cell, 2018, 34, 513-528.e8
33.498Citations (PDF)
90CRISPR-Cas guides the future of genetic engineering
Science, 2018, 361, 866-869
38.21,018Citations (PDF)
91The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders
Cell, 2018, 174, 505-520
35.188Citations (PDF)
92RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a
Cell Reports, 2018, 24, 1025-1036
6.494Citations (PDF)
93Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection
Trends in Cancer, 2018, 4, 499-512
14.096Citations (PDF)
94Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes
Nature Biotechnology, 2017, 35, 431-434
18.1265Citations (PDF)
95RNA-based recognition and targeting: sowing the seeds of specificity31.4152Citations (PDF)
96Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
Nucleic Acids Research, 2017, 45, e98-e98
16.262Citations (PDF)
97High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding7.7132Citations (PDF)
98RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes
Molecular Cell, 2017, 66, 373-383.e3
14.2208Citations (PDF)
99CRISPR–Cas9 Structures and Mechanisms
Annual Review of Biophysics, 2017, 46, 505-529
13.31,357Citations (PDF)
100Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response
Molecular Cell, 2017, 65, 168-175
14.242Citations (PDF)
101Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair18.8592Citations (PDF)
102The chemistry of Cas9 and its CRISPR colleagues23.4106Citations (PDF)
103CRISPR System: From Adaptive Immunity to Genome Editing1.80Citations (PDF)
104A Broad-Spectrum Inhibitor of CRISPR-Cas9
Cell, 2017, 170, 1224-1233.e15
35.1185Citations (PDF)
105Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
Nature, 2017, 550, 407-410
40.1848Citations (PDF)
106Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme6.4114Citations (PDF)
107Disabling Cas9 by an anti-CRISPR DNA mimic
Science Advances, 2017, 3,
11.3263Citations (PDF)
108A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
Science Advances, 2017, 3,
11.3202Citations (PDF)
109Structures of the CRISPR genome integration complex
Science, 2017, 357, 1113-1118
38.2104Citations (PDF)
110CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing14.1206Citations (PDF)
111Widespread Translational Remodeling during Human Neuronal Differentiation
Cell Reports, 2017, 21, 2005-2016
6.493Citations (PDF)
112A thermostable Cas9 with increased lifetime in human plasma14.1132Citations (PDF)
113Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
PLoS Biology, 2017, 15, e2001882
5.299Citations (PDF)
114RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System
PLoS ONE, 2017, 12, e0170552
2.565Citations (PDF)
115DNA recognition by an RNA-guided bacterial Argonaute
PLoS ONE, 2017, 12, e0177097
2.545Citations (PDF)
116Author response: RNA-dependent RNA targeting by CRISPR-Cas9
2017, ,
0Citations (PDF)
117CRISPR Immunological Memory Requires a Host Factor for Specificity
Molecular Cell, 2016, 62, 824-833
14.2126Citations (PDF)
118A bacterial Argonaute with noncanonical guide RNA specificity7.7107Citations (PDF)
119Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
Nature Biotechnology, 2016, 34, 646-651
18.1153Citations (PDF)
120Protecting genome integrity during CRISPR immune adaptation6.458Citations (PDF)
121Applications of CRISPR technologies in research and beyond
Nature Biotechnology, 2016, 34, 933-941
18.1701Citations (PDF)
122Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
Nature, 2016, 538, 270-273
40.1846Citations (PDF)
123DNA Targeting by a Minimal CRISPR RNA-Guided Cascade
Molecular Cell, 2016, 63, 840-851
14.263Citations (PDF)
124Foreign DNA capture during CRISPR–Cas adaptive immunity
Nature, 2016, 534, S13-S14
40.11Citations (PDF)
125ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing
Nature Methods, 2016, 13, 1013-1020
14.5158Citations (PDF)
126A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
Cell Reports, 2016, 17, 1438-1452
6.4136Citations (PDF)
127Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas914.1197Citations (PDF)
128Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
Cell, 2016, 164, 29-44
35.1812Citations (PDF)
129Programmable RNA Tracking in Live Cells with CRISPR/Cas9
Cell, 2016, 165, 488-496
35.1417Citations (PDF)
130Analog sensitive chemical inhibition of the <scp>DEAD</scp>‐box protein <scp>DDX</scp>3
Protein Science, 2016, 25, 638-649
5.911Citations (PDF)
131Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering
ACS Chemical Biology, 2016, 11, 681-688
3.976Citations (PDF)
132Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3
Journal of Biological Chemistry, 2016, 291, 2412-2421
2.365Citations (PDF)
133New CRISPR–Cas systems from uncultivated microbes
Nature, 2016, 542, 237-241
40.1446Citations (PDF)
134Cornerstones of CRISPR–Cas in drug discovery and therapy39.3352Citations (PDF)
135Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress
Oncotarget, 2016, 7, 28169-28182
1.763Citations (PDF)
136Author response: Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies
2016, ,
0Citations (PDF)
137Author response: Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex
2016, ,
0Citations (PDF)
138Genome editing: the end of the beginning
Genome Biology, 2015, 16,
8.415Citations (PDF)
139Genome-editing revolution: My whirlwind year with CRISPR
Nature, 2015, 528, 469-471
40.131Citations (PDF)
140Expanding the Biologist’s Toolkit with CRISPR-Cas9
Molecular Cell, 2015, 58, 568-574
14.2325Citations (PDF)
141Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis
Molecular Cell, 2015, 57, 397-407
14.2205Citations (PDF)
142Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
Nature, 2015, 519, 193-198
40.1267Citations (PDF)
143Rational design of a split-Cas9 enzyme complex7.7229Citations (PDF)
144Genomic Engineering and the Future of Medicine13.722Citations (PDF)
145The structural biology of CRISPR-Cas systems7.1135Citations (PDF)
146Generation of knock-in primary human T cells using Cas9 ribonucleoproteins7.7553Citations (PDF)
147CRISPR germline engineering—the community speaks
Nature Biotechnology, 2015, 33, 478-486
18.1104Citations (PDF)
148Conformational control of DNA target cleavage by CRISPR–Cas9
Nature, 2015, 527, 110-113
40.1460Citations (PDF)
149Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes
Molecular Cell, 2015, 60, 398-407
14.284Citations (PDF)
150Foreign DNA capture during CRISPR–Cas adaptive immunity
Nature, 2015, 527, 535-538
40.1152Citations (PDF)
151Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
Cell, 2015, 163, 854-865
35.1149Citations (PDF)
152Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
Molecular Cell, 2015, 59, 891-903
14.2199Citations (PDF)
153Cutting it close: CRISPR-associated endoribonuclease structure and function8.1109Citations (PDF)
154Author response: Tunable protein synthesis by transcript isoforms in human cells
2015, ,
0Citations (PDF)
155Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases
Nucleic Acids Research, 2014, 42, 1341-1353
16.264Citations (PDF)
156The new frontier of genome engineering with CRISPR-Cas9
Science, 2014, 346,
38.24,829Citations (PDF)
157Preface
Methods in Enzymology, 2014, , xix-xx
1.024Citations (PDF)
158New tools provide a second look at HDV ribozyme structure, dynamics and cleavage
Nucleic Acids Research, 2014, 42, 12833-12846
16.231Citations (PDF)
159Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Science, 2014, 343,
38.2907Citations (PDF)
160CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference7.7173Citations (PDF)
161Insights into RNA structure and function from genome-wide studies
Nature Reviews Genetics, 2014, 15, 469-479
19.1337Citations (PDF)
162DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Nature, 2014, 507, 62-67
40.11,394Citations (PDF)
163RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus
Molecular Cell, 2014, 56, 518-530
14.2242Citations (PDF)
164Evolutionarily Conserved Roles of the Dicer Helicase Domain in Regulating RNA Interference Processing
Journal of Biological Chemistry, 2014, 289, 28352-28362
2.318Citations (PDF)
165Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
Cell, 2014, 158, 1011-1021
35.1101Citations (PDF)
166Programmable RNA recognition and cleavage by CRISPR/Cas9
Nature, 2014, 516, 263-266
40.1525Citations (PDF)
167Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity6.4348Citations (PDF)
168Author response: Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
2014, ,
11Citations (PDF)
169Author response: RNA-guided assembly of Rev-RRE nuclear export complexes
2014, ,
0Citations (PDF)
170High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
Nature Biotechnology, 2013, 31, 839-843
18.11,188Citations (PDF)
171CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
Cell, 2013, 154, 442-451
35.12,760Citations (PDF)
172Structure and Activity of the RNA-Targeting Type III-B CRISPR-Cas Complex of Thermus thermophilus
Molecular Cell, 2013, 52, 135-145
14.2188Citations (PDF)
173Rewriting a genome
Nature, 2013, 495, 50-51
40.1173Citations (PDF)
174Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Cell, 2013, 152, 1173-1183
35.13,748Citations (PDF)
175Substrate-specific structural rearrangements of human Dicer6.480Citations (PDF)
176Molecular Mechanisms of RNA Interference
Annual Review of Biophysics, 2013, 42, 217-239
13.3818Citations (PDF)
177Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
Nucleic Acids Research, 2013, 41, 6568-6576
16.2162Citations (PDF)
178Multiple sensors ensure guide strand selection in human RNAi pathways
Rna, 2013, 19, 639-648
3.9107Citations (PDF)
179ATP-independent diffusion of double-stranded RNA binding proteins7.757Citations (PDF)
180Hepatitis C virus 3′UTR regulates viral translation through direct interactions with the host translation machinery
Nucleic Acids Research, 2013, 41, 7861-7874
16.257Citations (PDF)
181RNA–protein analysis using a conditional CRISPR nuclease7.768Citations (PDF)
182Defending the Genome: Regulatory RNA in Humans and Bacteria
FASEB Journal, 2013, 27,
0.70Citations (PDF)
183Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA
EMBO Journal, 2012, 31, 2824-2832
7.480Citations (PDF)
184Native Tandem and Ion Mobility Mass Spectrometry Highlight Structural and Modular Similarities in Clustered-Regularly-Interspaced Shot-Palindromic-Repeats (CRISPR)-associated Protein Complexes From Escherichia coli and Pseudomonas aeruginosa4.869Citations (PDF)
185Mechanism of substrate selection by a highly specific CRISPR endoribonuclease
Rna, 2012, 18, 661-672
3.9121Citations (PDF)
186TRBP alters human precursor microRNA processing in vitro
Rna, 2012, 18, 2012-2019
3.9110Citations (PDF)
187RNA processing enables predictable programming of gene expression
Nature Biotechnology, 2012, 30, 1002-1006
18.1164Citations (PDF)
188Coordinated Activities of Human Dicer Domains in Regulatory RNA Processing
Journal of Molecular Biology, 2012, 422, 466-476
4.262Citations (PDF)
189Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System
Molecular Cell, 2012, 46, 606-615
14.2201Citations (PDF)
190RNA-guided genetic silencing systems in bacteria and archaea
Nature, 2012, 482, 331-338
40.11,494Citations (PDF)
191A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Science, 2012, 337, 816-821
38.212,027Citations (PDF)
192Preliminary in vitro functional analysis of the DEAD‐box protein DDX3
FASEB Journal, 2012, 26,
0.70Citations (PDF)
193Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)7.7293Citations (PDF)
194Structures of the RNA-guided surveillance complex from a bacterial immune system
Nature, 2011, 477, 486-489
40.1318Citations (PDF)
195RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions7.7359Citations (PDF)
196Structural basis for CRISPR RNA-guided DNA recognition by Cascade6.4458Citations (PDF)
197An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse36.4147Citations (PDF)
198Crystal Structure of the HCV IRES Central Domain Reveals Strategy for Start-Codon Positioning
Structure, 2011, 19, 1456-1466
3.998Citations (PDF)
199Modeling and automation of sequencing-based characterization of RNA structure7.791Citations (PDF)
200Structural insights into RNA interference7.167Citations (PDF)
201Functional Overlap between eIF4G Isoforms in Saccharomyces cerevisiae
PLoS ONE, 2010, 5, e9114
2.548Citations (PDF)
202Substrate-Specific Kinetics of Dicer-Catalyzed RNA Processing
Journal of Molecular Biology, 2010, 404, 392-402
4.2122Citations (PDF)
203Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense
Structure, 2009, 17, 904-912
3.9202Citations (PDF)
204Structural insights into RNA processing by the human RISC-loading complex6.4199Citations (PDF)
205Autoinhibition of Human Dicer by Its Internal Helicase Domain
Journal of Molecular Biology, 2008, 380, 237-243
4.2178Citations (PDF)
206<i>In vitro</i> reconstitution of the human RISC-loading complex7.7333Citations (PDF)
207A three-dimensional view of the molecular machinery of RNA interference
Nature, 2008, 457, 405-412
40.1578Citations (PDF)
208Getting the message: Mechanisms of protein synthesis initiation
FASEB Journal, 2008, 22,
0.70Citations (PDF)
209Ribonuclease revisited: structural insights into ribonuclease III family enzymes7.1188Citations (PDF)
210GTP-dependent Formation of a Ribonucleoprotein Subcomplex Required for Ribosome Biogenesis
Journal of Molecular Biology, 2006, 356, 432-443
4.234Citations (PDF)
211Structural Characterization and Identification of Post‐Translational Modifications of Human Eukaryotic Initiation Factor 3 (eIF3) by FTICR Mass Spectrometry
FASEB Journal, 2006, 20,
0.70Citations (PDF)
212Structural Basis for RNA Processing by Dicer
FASEB Journal, 2006, 20,
0.70Citations (PDF)
213Ribozyme catalysis: not different, just worse6.4137Citations (PDF)
214Chemical biology at the crossroads of molecular structure and mechanism
Nature Chemical Biology, 2005, 1, 300-303
7.313Citations (PDF)
215Protein–nucleic acid interactions: unlocking mysteries old and new7.11Citations (PDF)
216An Essential GTPase Promotes Assembly of Preribosomal RNA Processing Complexes
Molecular Cell, 2005, 20, 633-643
14.265Citations (PDF)
217A conformational switch controls hepatitis delta virus ribozyme catalysis
Nature, 2004, 429, 201-205
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218Structural Insights Into the Signal Recognition Particle18.3111Citations (PDF)
219Protein–nucleic acid interactions7.17Citations (PDF)
220Structural Insights into Group II Intron Catalysis and Branch-Site Selection
Science, 2002, 295, 2084-2088
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221Structure and Function of the Eukaryotic Ribosome
Cell, 2002, 109, 153-156
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222The chemical repertoire of natural ribozymes
Nature, 2002, 418, 222-228
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223Direct pKaMeasurement of the Active-Site Cytosine in a Genomic Hepatitis Delta Virus Ribozyme15.788Citations (PDF)
224Erratum
Rna, 2001, 7, 642-643
3.93Citations (PDF)
225The stem-loop binding protein forms a highly stable and specific complex with the 3′ stem-loop of histone mRNAs
Rna, 2001, 7, 123-132
3.964Citations (PDF)
226Mechanism of ribosome recruitment by hepatitis C IRES RNA
Rna, 2001, 7, 194-206
3.9317Citations (PDF)
227Title is missing!
Nature Structural Biology, 2001, 8, 339-343
8.9213Citations (PDF)
228Crystal Structure of the Ribonucleoprotein Core of the Signal Recognition Particle
Science, 2000, 287, 1232-1239
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229Ribozyme Structures and Mechanisms18.3155Citations (PDF)
230The P5abc Peripheral Element Facilitates Preorganization of the Tetrahymena Group I Ribozyme for Catalysis
Biochemistry, 2000, 39, 2639-2651
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231A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes
Rna, 1999, 5, 720-727
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232Tertiary Motifs in RNA Structure and Folding15.0359Citations (PDF)
233Assembly of an Exceptionally Stable RNA Tertiary Interface in a Group I Ribozyme
Biochemistry, 1999, 38, 2982-2990
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234RNA FOLDS: Insights from Recent Crystal Structures20.783Citations (PDF)
235Crystal structure of a hepatitis delta virus ribozyme
Nature, 1998, 395, 567-574
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236The P4−P6 Domain Directs Higher Order Folding of theTetrahymenaRibozyme Core†
Biochemistry, 1997, 36, 3159-3169
2.970Citations (PDF)
237A magnesium ion core at the heart of a ribozyme domain
Nature Structural Biology, 1997, 4, 553-558
8.9258Citations (PDF)
238A molecular contortionist
Nature, 1997, 388, 830-831
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239Metal-binding sites in the major groove of a large ribozyme domain
Structure, 1996, 4, 1221-1229
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240Use of Cis- and Trans-Ribozymes to Remove 5' and 3' Heterogeneities From Milligrams of In Vitro Transcribed RNA
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241RNA-programmed genome editing in human cells
ELife, 0, 2,
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242Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
ELife, 0, 3,
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243RNA-guided assembly of Rev-RRE nuclear export complexes
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244Nucleosome breathing and remodeling constrain CRISPR-Cas9 function
ELife, 0, 5,
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245Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex
ELife, 0, 5,
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246RNA-dependent RNA targeting by CRISPR-Cas9
ELife, 0, 7,
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247Tunable protein synthesis by transcript isoforms in human cells
ELife, 0, 5,
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248Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies
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249Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a
ELife, 0, 8,
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250CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
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